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Article

pH-Sensitive Dairy-Derived Hydrogels with a Prolonged Drug Release Profile for Cancer Treatment

1
Institute of Nanostructures and Biosystems, Saratov State University, 83 Astrakhanskaya st., 410012 Saratov, Russia
2
Engineering Department, Lancaster University, Gillow Av., Lancaster LA1 4YW, UK
3
Skolkovo Institute of Science and Technology, Skolkovo Innovation Center, Building 3, 143026 Moscow, Russia
4
Materials Science Institute (MSI), Lancaster University, Gillow Av., Lancaster LA1 4YW, UK
*
Authors to whom correspondence should be addressed.
Academic Editor: Franz E. Weber
Materials 2021, 14(4), 749; https://doi.org/10.3390/ma14040749
Received: 16 December 2020 / Revised: 28 January 2021 / Accepted: 29 January 2021 / Published: 5 February 2021
(This article belongs to the Special Issue Advances in Polymeric Materials for Biomedical Applications)
A novel versatile biocompatible hydrogel of whey protein isolate (WPI) and two types of tannic acid (TAs) was prepared by crosslinking of WPI with TAs in a one-step method at high temperature for 30 min. WPI is one common protein-based preparation which is used for hydrogel formation. The obtained WPI-TA hydrogels were in disc form and retained their integrity after sterilization by autoclaving. Two TA preparations of differing molecular weight and chemical structure were compared, namely a polygalloyl glucose-rich extract-ALSOK 02-and a polygalloyl quinic acid-rich extract-ALSOK 04. Hydrogel formation was observed for WPI solutions containing both preparations. The swelling characteristics of hydrogels were investigated at room temperature at different pH values, namely 5, 7, and 9. The swelling ability of hydrogels was independent of the chemical structure of the added TAs. A trend of decrease of mass increase (MI) in hydrogels was observed with an increase in the TA/WPI ratio compared to the control WPI hydrogel without TA. This dependence (a MI decrease-TA/WPI ratio) was observed for hydrogels with different types of TA both in neutral and acidic conditions (pH 5.7). Under alkaline conditions (pH 9), negative values of swelling were observed for all hydrogels with a high content of TAs and were accompanied by a significant release of TAs from the hydrogel network. Our studies have shown that the release of TA from hydrogels containing ALSOK04 is higher than from hydrogels containing ALSOK 02. Moreover, the addition of TAs, which display a strong anti-cancer effect, increases the cytotoxicity of WPI-TAs hydrogels against the Hep-2 human laryngeal squamous carcinoma (Hep-2 cells) cell line. Thus, WPI-TA hydrogels with prolonged drug release properties and cytotoxicity effect can be used as anti-cancer scaffolds. View Full-Text
Keywords: whey protein isolate; hydrogel; tannic acid; anticancer scaffold whey protein isolate; hydrogel; tannic acid; anticancer scaffold
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MDPI and ACS Style

Mayorova, O.A.; Jolly, B.C.N.; Verkhovskii, R.A.; Plastun, V.O.; Sindeeva, O.A.; Douglas, T.E.L. pH-Sensitive Dairy-Derived Hydrogels with a Prolonged Drug Release Profile for Cancer Treatment. Materials 2021, 14, 749. https://doi.org/10.3390/ma14040749

AMA Style

Mayorova OA, Jolly BCN, Verkhovskii RA, Plastun VO, Sindeeva OA, Douglas TEL. pH-Sensitive Dairy-Derived Hydrogels with a Prolonged Drug Release Profile for Cancer Treatment. Materials. 2021; 14(4):749. https://doi.org/10.3390/ma14040749

Chicago/Turabian Style

Mayorova, Oksana A., Ben C.N. Jolly, Roman A. Verkhovskii, Valentina O. Plastun, Olga A. Sindeeva, and Timothy E.L. Douglas. 2021. "pH-Sensitive Dairy-Derived Hydrogels with a Prolonged Drug Release Profile for Cancer Treatment" Materials 14, no. 4: 749. https://doi.org/10.3390/ma14040749

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