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Electrochemotherapy and Other Clinical Applications of Electroporation for the Targeted Therapy of Metastatic Melanoma

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Department of Oncologic Dermatology-“Elias” Emergency University Hospital, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania
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Department of Microbiology and Immunology, Faculty of Biology, University of Bucharest, 030018 Bucharest, Romania
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Research Institute of the University of Bucharest, 050657 Bucharest, Romania
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Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 1-7 Polizu Street, 011061 Bucharest, Romania
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Department of Biophysics and Cellular Biotechnology, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania
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Department of Physical and Rehabilitation Medicine, “Elias” Emergency University Hospital, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania
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Faculty of Medicine, “Titu Maiorescu” University, 22 Dambrovnicului, 031593 Bucharest, Romania
*
Author to whom correspondence should be addressed.
Academic Editors: António Paulo and Paula Campello
Materials 2021, 14(14), 3985; https://doi.org/10.3390/ma14143985
Received: 31 May 2021 / Revised: 10 July 2021 / Accepted: 11 July 2021 / Published: 16 July 2021
(This article belongs to the Special Issue Targeted Drug Delivery)
Electrochemotherapy (ECT) is an effective bioelectrochemical procedure that uses controlled electrical pulses to facilitate the increase of intracellular concentration of certain substances (electropermeabilization/ reversible electroporation). ECT using antitumor drugs such as bleomycin and cisplatin is a minimally invasive targeted therapy that can be used as an alternative for oncologic patients not eligible for surgery or other standard therapies. Even though ECT is mainly applied as palliative care for metastases, it may also be used for primary tumors that are unresectable due to size and location. Skin neoplasms are the main clinical indication of ECT, the procedure reporting good curative results and high efficiency across all tumor types, including melanoma. In daily practice, there are many cases in which the patient’s quality of life can be significantly improved by a safe procedure such as ECT. Its popularity must be increased because it has a safe profile and minor local adverse reactions. The method can be used by dermatologists, oncologists, and surgeons. The aim of this paper is to review recent literature concerning electrochemotherapy and other clinical applications of electroporation for the targeted therapy of metastatic melanoma. View Full-Text
Keywords: electrochemotherapy; electropermeabilization; electroporation; metastatic melanoma; advanced melanoma; targeted therapy; gene transfer electrochemotherapy; electropermeabilization; electroporation; metastatic melanoma; advanced melanoma; targeted therapy; gene transfer
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MDPI and ACS Style

Cucu, C.I.; Giurcăneanu, C.; Popa, L.G.; Orzan, O.A.; Beiu, C.; Holban, A.M.; Grumezescu, A.M.; Matei, B.M.; Popescu, M.N.; Căruntu, C.; Mihai, M.M. Electrochemotherapy and Other Clinical Applications of Electroporation for the Targeted Therapy of Metastatic Melanoma. Materials 2021, 14, 3985. https://doi.org/10.3390/ma14143985

AMA Style

Cucu CI, Giurcăneanu C, Popa LG, Orzan OA, Beiu C, Holban AM, Grumezescu AM, Matei BM, Popescu MN, Căruntu C, Mihai MM. Electrochemotherapy and Other Clinical Applications of Electroporation for the Targeted Therapy of Metastatic Melanoma. Materials. 2021; 14(14):3985. https://doi.org/10.3390/ma14143985

Chicago/Turabian Style

Cucu, Corina I., Călin Giurcăneanu, Liliana G. Popa, Olguța A. Orzan, Cristina Beiu, Alina M. Holban, Alexandru M. Grumezescu, Bogdan M. Matei, Marius N. Popescu, Constantin Căruntu, and Mara M. Mihai 2021. "Electrochemotherapy and Other Clinical Applications of Electroporation for the Targeted Therapy of Metastatic Melanoma" Materials 14, no. 14: 3985. https://doi.org/10.3390/ma14143985

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