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Article

Impact of Cross-Linking of Collagen Matrices on Tissue Regeneration in a Rabbit Calvarial Bone Defect

1
Department of Cranio-Maxillofacial Surgery, Inselspital, Bern University Hospital, University of Bern, 3012 Bern, Switzerland
2
Department of Oral and Maxillofacial Surgery, School of Life Dentistry at Tokyo, The Nippon Dental University, Tokyo 102-8275, Japan
3
Advanced Research Center, School of Life Dentistry at Niigata, The Nippon Dental University, Niigata 951-8580, Japan
4
Department of Periodontology, University of Bern, 3012 Bern, Switzerland
*
Author to whom correspondence should be addressed.
Academic Editor: Steven J. Eppell
Materials 2021, 14(13), 3740; https://doi.org/10.3390/ma14133740
Received: 22 May 2021 / Revised: 28 June 2021 / Accepted: 2 July 2021 / Published: 4 July 2021
The cross-linking of collagen matrices (Cl_CM) may provide volume-stable enhanced defect regeneration when compared to non-cross-linked matrices (Ncl_CM). The aim of the present study was to investigate the bone forming potential of collagen matrices (CMs) and the effects of cross-linking CMs in a rabbit calvaria defect model. (1) Empty controls (n = 6), (2) Ncl_CM (n = 8), and (3) Cl_CM (n = 8) were selected to be observed for the healing in 10 mm critical-sized calvarial bone defects. The potential for the bone as well as the connective tissue formation were evaluated by micro-CT and histomorphometry at three months post-surgery. There were no statistically significant differences in terms of new bone volume in the defects between the groups. However, the Cl_CM induced significantly greater fibrous tissue regeneration (5.29 ± 1.57 mm2) when compared to the controls (3.51 ± 0.93 mm2) by histomorphometry. The remnants of collagen fibers with immune cells, including macrophages and giant cells, were occasionally observed in the Cl_CM group but not in the Ncl_CM group. In conclusion, the cross-linking of collagen did not influence the potential for bone formation. Nevertheless, Cl_CM might be advantageous for the maintenance of fibrous tissue volume without disturbing bone formation in the defects. View Full-Text
Keywords: collagen; cross-linking; tissue augmentation; bone formation collagen; cross-linking; tissue augmentation; bone formation
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MDPI and ACS Style

Fujioka-Kobayashi, M.; Andrejova, E.; Katagiri, H.; Schaller, B.; Sculean, A.; Imber, J.-C.; Lang, N.P.; Saulacic, N. Impact of Cross-Linking of Collagen Matrices on Tissue Regeneration in a Rabbit Calvarial Bone Defect. Materials 2021, 14, 3740. https://doi.org/10.3390/ma14133740

AMA Style

Fujioka-Kobayashi M, Andrejova E, Katagiri H, Schaller B, Sculean A, Imber J-C, Lang NP, Saulacic N. Impact of Cross-Linking of Collagen Matrices on Tissue Regeneration in a Rabbit Calvarial Bone Defect. Materials. 2021; 14(13):3740. https://doi.org/10.3390/ma14133740

Chicago/Turabian Style

Fujioka-Kobayashi, Masako, Elena Andrejova, Hiroki Katagiri, Benoit Schaller, Anton Sculean, Jean-Claude Imber, Niklaus P. Lang, and Nikola Saulacic. 2021. "Impact of Cross-Linking of Collagen Matrices on Tissue Regeneration in a Rabbit Calvarial Bone Defect" Materials 14, no. 13: 3740. https://doi.org/10.3390/ma14133740

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