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Influence of the Titanium Implant Surface Treatment on the Surface Roughness and Chemical Composition
Open AccessArticle

Repeated Exposure of Nanostructured Titanium to Osteoblasts with Respect to Peri-Implantitis

Department of Medical Chemistry and Biochemistry, Faculty of Medicine in Pilsen, Charles University, Karlovarska 48, 301 66 Pilsen, Czech Republic
Timplant s.r.o., Sjednoceni 77/1, 72525 Ostrava, Czech Republic
Department of Stomatology, Faculty of Medicine in Pilsen, University Hospital and Charles University, alej Svobody 80, 301 00 Pilsen, Czech Republic
Author to whom correspondence should be addressed.
Materials 2020, 13(3), 697;
Received: 3 January 2020 / Revised: 30 January 2020 / Accepted: 1 February 2020 / Published: 4 February 2020
(This article belongs to the Special Issue Materials in Implant Dentistry and Regenerative Medicine)
Titanium offers excellent biocompatibility and extraordinary mechanical properties. As a result, it is used as a material for dental implants. Implants infected by peri-implantitis can be cleaned for successful re-osseointegration. Optimal surface properties, such as roughness and wettability, have a significant impact on cell adhesion. The aim of this study was to evaluate the adhesion and proliferation of osteoblasts on the surface of repeatedly cleaned nanostructured titanium samples. Human osteoblast-like cells MG-63 were seeded on nanostructured titanium specimens manufactured from rods produced by the equal channel angular pressing. For surface characterization, roughness and wettability were measured. Cell adhesion after 2 h as well as cell proliferation after 48 h from plating was assessed. We have found that this repeated cleaning of titanium surface reduced cell adhesion as well as proliferation. These events depend on interplay of surface properties, such as wettability, roughness and topography. It is difficult to distinguish which factors are responsible for these events and further investigations will be required. However, even after the several rounds of repeated cleaning, there was a certain rate of adhesion and proliferation recorded. Therefore the attempts to save failing implants by using in situ cleaning are promising. View Full-Text
Keywords: nanostructured titanium; peri-implantitis; osteoblasts proliferation; biocompatibility nanostructured titanium; peri-implantitis; osteoblasts proliferation; biocompatibility
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Babuska, V.; Kolaja Dobra, J.; Dluhos, L.; Dvorakova, J.; Moztarzadeh, J.; Hrusak, D.; Kulda, V. Repeated Exposure of Nanostructured Titanium to Osteoblasts with Respect to Peri-Implantitis. Materials 2020, 13, 697.

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