Photocurable Polymeric Blends for Surgical Application

Cernadas, Teresa; Santos, Marta; Miguel, Sónia P.; Correia, Ilídio J.; Alves, Patrícia; Ferreira, Paula

doi:10.3390/ma13245681

Open AccessEditor’s ChoiceArticle

Photocurable Polymeric Blends for Surgical Application

by

Teresa Cernadas

^1,†

,

Marta Santos

^1,†,

Sónia P. Miguel

^2,3

,

Ilídio J. Correia

^1,2,

Patrícia Alves

¹

and

Paula Ferreira

^1,*

¹

CIEPQPF, Department of Chemical Engineering, University of Coimbra, P-3030 790 Coimbra, Portugal

²

CICS-UBI, Health Sciences Research Center, University of Beira Interior, P-6200 506 Covilhã, Portugal

³

CPIRN-IPG, Center of Potential and Innovation of Natural Resources, Polytechnic Institute of Guarda, Av. Dr. Francisco de Sá Carneiro, 6300-559 Guarda, Portugal

^*

Author to whom correspondence should be addressed.

^†

These authors have made an equal contribution to this study.

Materials 2020, 13(24), 5681; https://doi.org/10.3390/ma13245681

Submission received: 22 October 2020 / Revised: 7 December 2020 / Accepted: 9 December 2020 / Published: 12 December 2020

(This article belongs to the Special Issue Synthesis, Properties and Applications of Polymer Blends)

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Abstract

The preparation of photocrosslinkable bioadhesives synthesized from oligomers of lactic acid and polycaprolactone (PCL), both functionalized with 2-isocyanoethyl acrylate (AOI), were studied. The obtained modified macromers of LA-AOI (mLA) and PCL-AOI (mCL) were chemically characterized by ¹H NMR and used to formulate polymeric blends with different mass proportions, 1:1, 1:2 and 2:1, respectively. Subsequently, the produced blends were crosslinked, considering two UV irradiation times: 30 and 120 s. After their production, the thermal and mechanical properties of bioadhesives were assessed, where upon the rheology, gel content, hydrolytic degradation and dynamic contact angles were determined. Furthermore, the cytotoxic profile of bioadhesives was evaluated in contact with human dermal fibroblasts cells, whereas their antibacterial effect was studied monitoring Escherichia coli and S. aureus growth. Overall, flexible and resistant films were obtained, presenting promising features to be used as surgical bioadhesives.

Keywords: photocuring; polymeric blends; bioadhesive; biocompatibility; antibacterial activity

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MDPI and ACS Style

Cernadas, T.; Santos, M.; Miguel, S.P.; Correia, I.J.; Alves, P.; Ferreira, P. Photocurable Polymeric Blends for Surgical Application. Materials 2020, 13, 5681. https://doi.org/10.3390/ma13245681

AMA Style

Cernadas T, Santos M, Miguel SP, Correia IJ, Alves P, Ferreira P. Photocurable Polymeric Blends for Surgical Application. Materials. 2020; 13(24):5681. https://doi.org/10.3390/ma13245681

Chicago/Turabian Style

Cernadas, Teresa, Marta Santos, Sónia P. Miguel, Ilídio J. Correia, Patrícia Alves, and Paula Ferreira. 2020. "Photocurable Polymeric Blends for Surgical Application" Materials 13, no. 24: 5681. https://doi.org/10.3390/ma13245681

APA Style

Cernadas, T., Santos, M., Miguel, S. P., Correia, I. J., Alves, P., & Ferreira, P. (2020). Photocurable Polymeric Blends for Surgical Application. Materials, 13(24), 5681. https://doi.org/10.3390/ma13245681

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Photocurable Polymeric Blends for Surgical Application

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