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Article

Controlling the Porosity and Biocidal Properties of the Chitosan-Hyaluronate Matrix Hydrogel Nanocomposites by the Addition of 2D Ti3C2Tx MXene

1
Faculty of Materials Science and Engineering, Warsaw University of Technology, Woloska 141, 02-507 Warsaw, Poland
2
Faculty of Building Services, Hydro and Environmental Engineering, Warsaw University of Technology, Nowowiejska 20, 00-653 Warsaw, Poland
3
Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, Poland
*
Author to whom correspondence should be addressed.
Materials 2020, 13(20), 4587; https://doi.org/10.3390/ma13204587
Received: 1 August 2020 / Revised: 18 September 2020 / Accepted: 24 September 2020 / Published: 15 October 2020
A recent discovery of the unique biological properties of two-dimensional transition metal carbides (MXenes) resulted in intensive research on their application in various biotechnological areas, including polymeric nanocomposite systems. However, the true potential of MXene as an additive to bioactive natural porous composite structures has yet to be fully explored. Here, we report that the addition of 2D Ti3C2Tx MXene by reducing the porosity of the chitosan-hyaluronate matrix nanocomposite structures, stabilized by vitamin C, maintains their desired antibacterial properties. This was confirmed by micro computed tomography (micro-CT) visualization which enables insight into the porous structure of nanocomposites. It was also found that given large porosity of the nanocomposite a small amount of MXene (1–5 wt.%) was effective against gram-negative Escherichia coli, gram-positive Staphylococcus aureus, and Bacillus sp. bacteria in a hydrogel system. Such an approach unequivocally advances the future design approaches of modern wound healing dressing materials with the addition of MXenes. View Full-Text
Keywords: MXenes; chitosan; hyaluronate; nanocomposite hydrogel; antibacterial; porosity; computed tomography MXenes; chitosan; hyaluronate; nanocomposite hydrogel; antibacterial; porosity; computed tomography
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MDPI and ACS Style

Rozmysłowska-Wojciechowska, A.; Karwowska, E.; Gloc, M.; Woźniak, J.; Petrus, M.; Przybyszewski, B.; Wojciechowski, T.; Jastrzębska, A.M. Controlling the Porosity and Biocidal Properties of the Chitosan-Hyaluronate Matrix Hydrogel Nanocomposites by the Addition of 2D Ti3C2Tx MXene. Materials 2020, 13, 4587. https://doi.org/10.3390/ma13204587

AMA Style

Rozmysłowska-Wojciechowska A, Karwowska E, Gloc M, Woźniak J, Petrus M, Przybyszewski B, Wojciechowski T, Jastrzębska AM. Controlling the Porosity and Biocidal Properties of the Chitosan-Hyaluronate Matrix Hydrogel Nanocomposites by the Addition of 2D Ti3C2Tx MXene. Materials. 2020; 13(20):4587. https://doi.org/10.3390/ma13204587

Chicago/Turabian Style

Rozmysłowska-Wojciechowska, Anita, Ewa Karwowska, Michał Gloc, Jarosław Woźniak, Mateusz Petrus, Bartłomiej Przybyszewski, Tomasz Wojciechowski, and Agnieszka M. Jastrzębska 2020. "Controlling the Porosity and Biocidal Properties of the Chitosan-Hyaluronate Matrix Hydrogel Nanocomposites by the Addition of 2D Ti3C2Tx MXene" Materials 13, no. 20: 4587. https://doi.org/10.3390/ma13204587

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