Next Article in Journal
Experimental Study of the Mechanical Properties and Microstructures of Lightweight Toughness Cement-Based Composites
Next Article in Special Issue
The Radiosensitizing Effect of Zinc Oxide Nanoparticles in Sub-Cytotoxic Dosing Is Associated with Oxidative Stress In Vitro
Previous Article in Journal
Using Solubility Parameters to Model More Environmentally Friendly Solvent Blends for Organic Solar Cell Active Layers
Previous Article in Special Issue
Randomized Controlled Clinical Trial of Nanostructured Carbonated Hydroxyapatite for Alveolar Bone Repair
Open AccessArticle

Novel Eco-Synthesis of PD Silver Nanoparticles: Characterization, Assessment of Its Antimicrobial and Cytotoxicity Properties

1
King Abdullah Institute for Nanotechnology, King Saud University, Riyadh 11451, Saudi Arabia
2
Department of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia
3
Department of Chemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia
*
Authors to whom correspondence should be addressed.
Materials 2019, 12(23), 3890; https://doi.org/10.3390/ma12233890
Received: 2 October 2019 / Revised: 15 November 2019 / Accepted: 18 November 2019 / Published: 25 November 2019
(This article belongs to the Special Issue Biomaterial Design for Disease Applications)
Nanomedicine is growing due to the development of new medical diagnostic tools and new nanostructure-based therapies that exert direct biological action or function as pharmacological carriers. Nanoparticles (NPs) synthesis provides an eco-friendly approach for different applications. Among NPs, silver NPs (AgNPs) are gaining considerable research interest due to their broad range of activity and their usability in the medical and biotechnology fields. In this study, a new AgNP synthesis method was developed using an aqueous pigeon dropping (PD) extract in silver nitrate (AgNO3). The rapid of AgNPs yield was detected visually. Analysis of UV-vis spectroscopy, energy-dispersive X-ray spectroscopy (EDX), dynamic light scattering (DLS) and electron microscopy (TEM) transmission showed a spherical or near spherical shape of AgNPs with mean size of 135 nm. AgNPs antimicrobial activities (anti-bacterial and anti-fungal) were determined using agar well diffusion method. These NPs further screened for anticancer activity in vitro using A-549 and MCF-7 cell lines. The results showed that the inhibition zone for the obtained PD AgNPs versus Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Bacillus were 26, 18, 17 and 15 mm, respectively. PD AgNPs showed the highest antifungal effect against Aspergillus flavus and the lowest effect against Penicillium griseofulvum. In vitro anti-cancer activities showed that the inhibitory concentration of 50% (IC50) of AgNPs was 10.3 ± 1.15 and 12.19 ± 0.75 µg mL−1 against A-549 and MCF-7 cancer cell lines, respectively. View Full-Text
Keywords: AgNPs; pigeon droppings; TEM; EDX; antimicrobial; anticancer AgNPs; pigeon droppings; TEM; EDX; antimicrobial; anticancer
Show Figures

Graphical abstract

MDPI and ACS Style

A. Awad, M.; M. Alkhulaifi, M.; S. Aldosari, N.; Alzahly, S.; Aldalbahi, A. Novel Eco-Synthesis of PD Silver Nanoparticles: Characterization, Assessment of Its Antimicrobial and Cytotoxicity Properties. Materials 2019, 12, 3890.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop