Next Article in Journal
Analysis on the Effects of the Human Body on the Performance of Electro-Textile Antennas for Wearable Monitoring and Tracking Application
Next Article in Special Issue
Dimensional Control in Polyoxometalate Crystals Hybridized with Amphiphilic Polymerizable Ionic Liquids
Previous Article in Journal
Effect of Early Age-Curing Methods on Drying Shrinkage of Alkali-Activated Slag Concrete
Previous Article in Special Issue
Synthesis of Metallic Nanocrystals: From Noble Metals to Base Metals
Open AccessArticle

Tuning the Hydrophobicity of a Hydrogel Using Self-Assembled Domains of Polymer Cross-Linkers

Department of Chemical Engineering, Soongsil University, 369, Sangdo-Ro, Dongjak-Gu, Seoul 06978, Korea
*
Author to whom correspondence should be addressed.
Materials 2019, 12(10), 1635; https://doi.org/10.3390/ma12101635
Received: 9 April 2019 / Revised: 14 May 2019 / Accepted: 17 May 2019 / Published: 19 May 2019
(This article belongs to the Special Issue Growth and Design of Inorganic Crystal)
Hydrogels incorporated with hydrophobic motifs have received considerable attention to recapitulate the cellular microenvironments, specifically for the bio-mineralization of a 3D matrix. Introduction of hydrophobic molecules into a hydrogel often results in irregular arrangement of the motifs, and further phase separation of hydrophobic domains, but limited efforts have been made to resolve this challenge in developing the hydrophobically-modified hydrogel. Therefore, this study presents an advanced integrative strategy to incorporate hydrophobic domains regularly in a hydrogel using self-assembled domains formed with polymer cross-linkers, building blocks of a hydrogel. Self-assemblies formed by polymer cross-linkers were examined as micro-domains to incorporate hydrophobic motifs in a hydrogel. The self-assembled structures in a pre-gelled solution were confirmed with the fluorescence analysis and the hydrophobicity of a hydrogel could be tuned by incorporating the hydrophobic chains in a controlled manner. Overall, the results of this study would greatly serve to tuning performance of a wide array of hydrophobically-modified hydrogels in drug delivery, cell therapies and tissue engineering. View Full-Text
Keywords: hydrogel; hydrophobicity; self-assembly; degree of swelling hydrogel; hydrophobicity; self-assembly; degree of swelling
Show Figures

Figure 1

MDPI and ACS Style

Kim, H.-J.; Cho, S.; Oh, S.J.; Shin, S.G.; Ryu, H.W.; Jeong, J.H. Tuning the Hydrophobicity of a Hydrogel Using Self-Assembled Domains of Polymer Cross-Linkers. Materials 2019, 12, 1635.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop