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Open AccessArticle

Antimicrobial Features of Organic Functionalized Graphene-Oxide with Selected Amines

1
Biochemistry and Catalysis, Department of Organic Chemistry, Faculty of Chemistry, University of Bucharest, 030018 Bucharest, Romania
2
Institute of Physical Chemistry, 202 Spl. Independentei, 060021 Bucharest, Romania
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Faculty of Biology, University of Bucharest, 030018 Bucharest, Romania
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Research Institute of the University of Bucharest, ICUB, 050095 Bucharest, Romania
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Department of Pharmaceutical Chemistry, Carol Davila’ University of Medicine and Pharmacy, 020956 Bucharest, Romania
*
Author to whom correspondence should be addressed.
Materials 2018, 11(9), 1704; https://doi.org/10.3390/ma11091704
Received: 20 August 2018 / Revised: 5 September 2018 / Accepted: 11 September 2018 / Published: 13 September 2018
(This article belongs to the Special Issue Physical Anti-Bacterial Nanostructured Biomaterials)
(1) Background: Graphene oxide is a new carbon-based material that contains functional groups (carboxyl, hydroxyl, carbonyl, epoxy) and therefore can be easily functionalized with organic compounds of interest, yielding hybrid materials with important properties and applications. (2) Methods: Graphene oxide has been obtained by a modified Hummers method and activated by thionyl chloride in order to be covalently functionalized with amines. Thus obtained hybrid materials were characterized by infrared and Raman spectroscopy, elemental analysis and scanning electron microscopy and then tested for their antimicrobial and anti-biofilm activity. (3) Results: Eight amines of interest were used to functionalize grapheme oxide and the materials thus obtained were tested against Gram-negative (Escherichia coli, Pseudomonas aeruginosa) and Gram-positive (Staphylococcus aureus) bacterial strainsin plankonic and biofilm growth state. Both amines, as well as the functionalized materials, exhibited anti-microbial features. Three to five functionalized graphene oxide materials exhibited improved inhibitory activity against planktonic strains as compared with the respective amines. In exchange, the amines alone proved generally more efficient against biofilm-embedded cells. (4) Conclusions: Such hybrid materials may have a wide range of potential use in biomedical applications. View Full-Text
Keywords: graphene oxide; synthesis; functionalization; amines; antibacterial; anti-biofilm graphene oxide; synthesis; functionalization; amines; antibacterial; anti-biofilm
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Zarafu, I.; Turcu, I.; Culiță, D.C.; Petrescu, S.; Popa, M.; Chifiriuc, M.C.; Limban, C.; Telehoiu, A.; Ioniță, P. Antimicrobial Features of Organic Functionalized Graphene-Oxide with Selected Amines. Materials 2018, 11, 1704.

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