Next Article in Journal
Targeting the Bacterial Protective Armour; Challenges and Novel Strategies in the Treatment of Microbial Biofilm
Next Article in Special Issue
The Fate of Osteoblast-Like MG-63 Cells on Pre-Infected Bactericidal Nanostructured Titanium Surfaces
Previous Article in Journal
Cell Type Influences Local Delivery of Biomolecules from a Bioinspired Apatite Drug Delivery System
Previous Article in Special Issue
Pheochromocytoma (PC12) Cell Response on Mechanobactericidal Titanium Surfaces
Open AccessArticle

Antimicrobial Features of Organic Functionalized Graphene-Oxide with Selected Amines

Biochemistry and Catalysis, Department of Organic Chemistry, Faculty of Chemistry, University of Bucharest, 030018 Bucharest, Romania
Institute of Physical Chemistry, 202 Spl. Independentei, 060021 Bucharest, Romania
Faculty of Biology, University of Bucharest, 030018 Bucharest, Romania
Research Institute of the University of Bucharest, ICUB, 050095 Bucharest, Romania
Department of Pharmaceutical Chemistry, Carol Davila’ University of Medicine and Pharmacy, 020956 Bucharest, Romania
Author to whom correspondence should be addressed.
Materials 2018, 11(9), 1704;
Received: 20 August 2018 / Revised: 5 September 2018 / Accepted: 11 September 2018 / Published: 13 September 2018
(This article belongs to the Special Issue Physical Anti-Bacterial Nanostructured Biomaterials)
(1) Background: Graphene oxide is a new carbon-based material that contains functional groups (carboxyl, hydroxyl, carbonyl, epoxy) and therefore can be easily functionalized with organic compounds of interest, yielding hybrid materials with important properties and applications. (2) Methods: Graphene oxide has been obtained by a modified Hummers method and activated by thionyl chloride in order to be covalently functionalized with amines. Thus obtained hybrid materials were characterized by infrared and Raman spectroscopy, elemental analysis and scanning electron microscopy and then tested for their antimicrobial and anti-biofilm activity. (3) Results: Eight amines of interest were used to functionalize grapheme oxide and the materials thus obtained were tested against Gram-negative (Escherichia coli, Pseudomonas aeruginosa) and Gram-positive (Staphylococcus aureus) bacterial strainsin plankonic and biofilm growth state. Both amines, as well as the functionalized materials, exhibited anti-microbial features. Three to five functionalized graphene oxide materials exhibited improved inhibitory activity against planktonic strains as compared with the respective amines. In exchange, the amines alone proved generally more efficient against biofilm-embedded cells. (4) Conclusions: Such hybrid materials may have a wide range of potential use in biomedical applications. View Full-Text
Keywords: graphene oxide; synthesis; functionalization; amines; antibacterial; anti-biofilm graphene oxide; synthesis; functionalization; amines; antibacterial; anti-biofilm
Show Figures

Figure 1

MDPI and ACS Style

Zarafu, I.; Turcu, I.; Culiță, D.C.; Petrescu, S.; Popa, M.; Chifiriuc, M.C.; Limban, C.; Telehoiu, A.; Ioniță, P. Antimicrobial Features of Organic Functionalized Graphene-Oxide with Selected Amines. Materials 2018, 11, 1704.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop