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Pheochromocytoma (PC12) Cell Response on Mechanobactericidal Titanium Surfaces

School of Science, Swinburne University of Technology, Hawthorn, VIC 3122, Australia
Centre for Micro-Photonics, Swinburne University of Technology, Hawthorn, VIC 3122, Australia
Frankfurt Orofacial Regenerative Medicine, University Hospital Frankfurt, Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany
Departament d’Enginyeria Quimica, Universitat Rovira i Virgili, 26 Avenue dels Paisos Catalans, 43007 Tarragona, Spain
CSIRO Manufacturing, Clayton, VIC 3168, Australia
School of Science, RMIT University, Melbourne, VIC 3001, Australia
Author to whom correspondence should be addressed.
Materials 2018, 11(4), 605;
Received: 13 March 2018 / Revised: 31 March 2018 / Accepted: 11 April 2018 / Published: 14 April 2018
(This article belongs to the Special Issue Physical Anti-Bacterial Nanostructured Biomaterials)
Titanium is a biocompatible material that is frequently used for making implantable medical devices. Nanoengineering of the surface is the common method for increasing material biocompatibility, and while the nanostructured materials are well-known to represent attractive substrata for eukaryotic cells, very little information has been documented about the interaction between mammalian cells and bactericidal nanostructured surfaces. In this study, we investigated the effect of bactericidal titanium nanostructures on PC12 cell attachment and differentiation—a cell line which has become a widely used in vitro model to study neuronal differentiation. The effects of the nanostructures on the cells were then compared to effects observed when the cells were placed in contact with non-structured titanium. It was found that bactericidal nanostructured surfaces enhanced the attachment of neuron-like cells. In addition, the PC12 cells were able to differentiate on nanostructured surfaces, while the cells on non-structured surfaces were not able to do so. These promising results demonstrate the potential application of bactericidal nanostructured surfaces in biomedical applications such as cochlear and neuronal implants. View Full-Text
Keywords: mechanobactericidal surfaces; nanostructures; titanium; PC12 cells mechanobactericidal surfaces; nanostructures; titanium; PC12 cells
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MDPI and ACS Style

Wandiyanto, J.V.; Linklater, D.; Tharushi Perera, P.G.; Orlowska, A.; Truong, V.K.; Thissen, H.; Ghanaati, S.; Baulin, V.; Crawford, R.J.; Juodkazis, S.; Ivanova, E.P. Pheochromocytoma (PC12) Cell Response on Mechanobactericidal Titanium Surfaces. Materials 2018, 11, 605.

AMA Style

Wandiyanto JV, Linklater D, Tharushi Perera PG, Orlowska A, Truong VK, Thissen H, Ghanaati S, Baulin V, Crawford RJ, Juodkazis S, Ivanova EP. Pheochromocytoma (PC12) Cell Response on Mechanobactericidal Titanium Surfaces. Materials. 2018; 11(4):605.

Chicago/Turabian Style

Wandiyanto, Jason V., Denver Linklater, Pallale G. Tharushi Perera, Anna Orlowska, Vi K. Truong, Helmut Thissen, Shahram Ghanaati, Vladimir Baulin, Russell J. Crawford, Saulius Juodkazis, and Elena P. Ivanova. 2018. "Pheochromocytoma (PC12) Cell Response on Mechanobactericidal Titanium Surfaces" Materials 11, no. 4: 605.

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