Materials 2018, 11(4), 605; https://doi.org/10.3390/ma11040605
Pheochromocytoma (PC12) Cell Response on Mechanobactericidal Titanium Surfaces
Jason V. Wandiyanto 1, Denver Linklater 1,2, Pallale G. Tharushi Perera 1, Anna Orlowska 3,4, Vi Khanh Truong 1, Helmut Thissen 5, Shahram Ghanaati 3, Vladimir Baulin 4
, Russell J. Crawford 6, Saulius Juodkazis 1,2 and Elena P. Ivanova 6,*
, Russell J. Crawford 6, Saulius Juodkazis 1,2 and Elena P. Ivanova 6,*
1
School of Science, Swinburne University of Technology, Hawthorn, VIC 3122, Australia
2
Centre for Micro-Photonics, Swinburne University of Technology, Hawthorn, VIC 3122, Australia
3
Frankfurt Orofacial Regenerative Medicine, University Hospital Frankfurt, Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany
4
Departament d’Enginyeria Quimica, Universitat Rovira i Virgili, 26 Avenue dels Paisos Catalans, 43007 Tarragona, Spain
5
CSIRO Manufacturing, Clayton, VIC 3168, Australia
6
School of Science, RMIT University, Melbourne, VIC 3001, Australia
*
Author to whom correspondence should be addressed.
Received: 13 March 2018 / Revised: 31 March 2018 / Accepted: 11 April 2018 / Published: 14 April 2018
(This article belongs to the Special Issue Physical Anti-Bacterial Nanostructured Biomaterials)
Abstract
Titanium is a biocompatible material that is frequently used for making implantable medical devices. Nanoengineering of the surface is the common method for increasing material biocompatibility, and while the nanostructured materials are well-known to represent attractive substrata for eukaryotic cells, very little information has been documented about the interaction between mammalian cells and bactericidal nanostructured surfaces. In this study, we investigated the effect of bactericidal titanium nanostructures on PC12 cell attachment and differentiation—a cell line which has become a widely used in vitro model to study neuronal differentiation. The effects of the nanostructures on the cells were then compared to effects observed when the cells were placed in contact with non-structured titanium. It was found that bactericidal nanostructured surfaces enhanced the attachment of neuron-like cells. In addition, the PC12 cells were able to differentiate on nanostructured surfaces, while the cells on non-structured surfaces were not able to do so. These promising results demonstrate the potential application of bactericidal nanostructured surfaces in biomedical applications such as cochlear and neuronal implants. View Full-TextKeywords:
mechanobactericidal surfaces; nanostructures; titanium; PC12 cells
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Wandiyanto, J.V.; Linklater, D.; Tharushi Perera, P.G.; Orlowska, A.; Truong, V.K.; Thissen, H.; Ghanaati, S.; Baulin, V.; Crawford, R.J.; Juodkazis, S.; Ivanova, E.P. Pheochromocytoma (PC12) Cell Response on Mechanobactericidal Titanium Surfaces. Materials 2018, 11, 605.
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