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Open AccessArticle

A Facile Flow-Casting Production of Bioactive Glass Coatings on Porous Titanium for Bone Tissue Engineering

by Haiou Yang 1,†, Qijie Zhu 2,†, Hongfei Qi 2, Xianhu Liu 3, Meixia Ma 1 and Qiang Chen 1,2,*
State Key Laboratory of Solidification Processing, Northwestern Polytechnical University, Xi’an 710072, China
Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an 710072, China
National Engineering Research Center for Advanced Polymer Processing Technology, Zhengzhou University, Zhengzhou 450002, China
Author to whom correspondence should be addressed.
The authors contributed equally to this work.
Materials 2018, 11(9), 1540;
Received: 29 June 2018 / Revised: 17 August 2018 / Accepted: 22 August 2018 / Published: 27 August 2018
(This article belongs to the Special Issue Bioceramics: Bioinert, Bioactive, and Coatings)
Additive manufacturing enabled the fabrication of porous titanium (PT) with customized porosity and mechanical properties. However, functionalization of PT surfaces with bioactive coatings is being challenged due to sophisticated geometry and highly porous structure. In this study, a facile flow-casting technique was developed to produce homogeneous 45S5 bioactive glass (BG) coatings on the entire surface of PT. The coating weight as a function of BG concentration in a BG-PVA slurry was investigated to achieve controllable coating yield without blocking macropore structure. The annealing-treated BG coating not only exhibited compact adhesion confirmed by qualitative sonication treatment, but also enhanced the mechanical properties of PT scaffolds. Moreover, in-vitro assessments of BG-coated PT cultured with MC3T3-E1 cells was carried out having in mind their potential as bioactive bone implants. The experimental results in this study offer a simple and versatile approach for the bio-functionalization of PT and other porous biomedical devices. View Full-Text
Keywords: porous titanium; bioactive glasses; coating; bone implant porous titanium; bioactive glasses; coating; bone implant
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MDPI and ACS Style

Yang, H.; Zhu, Q.; Qi, H.; Liu, X.; Ma, M.; Chen, Q. A Facile Flow-Casting Production of Bioactive Glass Coatings on Porous Titanium for Bone Tissue Engineering. Materials 2018, 11, 1540.

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