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Smart Injectable Self-Setting Monetite Based Bioceramics for Orthopedic Applications

Department of Mechanical Industrial and Manufacturing Engineering, The University of Toledo, Toledo, OH 43606, USA
Department of Bioengineering, the University of Toledo, Toledo, OH 43606, USA
Author to whom correspondence should be addressed.
Materials 2018, 11(7), 1258;
Received: 22 June 2018 / Revised: 12 July 2018 / Accepted: 18 July 2018 / Published: 22 July 2018
(This article belongs to the Special Issue Bioceramics: Bioinert, Bioactive, and Coatings)
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The present study is the first of its kind dealing with the development of a specific bioceramic which qualifies as a potential material in hard-tissue replacements. Specifically, we report the synthesis and evaluation of smart injectable calcium phosphate bone cement (CPC) which we believe will be suitable for various kinds of orthopedic and spinal-fusion applications. The smart nature of this next generation orthopedic implant is attained by incorporating piezoelectric barium titanate (BT) particles into monetite-based (dicalcium phosphate anhydrous, DCPA) CPC composition. The main goal is to take advantage of the piezoelectric properties of BT, as electromechanical effect plays a vital role in fracture healing at the defect site and bone integration with the implant. Furthermore, radiopacity of BT would help in easy detection of the CPC presence at the fracture site during surgery. Results reveal that BT addition favors important properties of bone cement such as good compressive strength, injectability, bioactivity, biocompatibility, and even washout resistance. Most importantly, the self-setting nature of the bone cements are not compromised with BT incorporation. The in vitro results confirm that the developed bone-cement abides by the standard orthopedic requirements making it apt for real-time prosthetic materials. View Full-Text
Keywords: smart; calcium phosphate; monetite; barium titanate; bioceramics; orthopedics smart; calcium phosphate; monetite; barium titanate; bioceramics; orthopedics

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Koju, N.; Sikder, P.; Gaihre, B.; B. Bhaduri, S. Smart Injectable Self-Setting Monetite Based Bioceramics for Orthopedic Applications. Materials 2018, 11, 1258.

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