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Materials 2018, 11(5), 714; https://doi.org/10.3390/ma11050714

Histological Evaluation of the Healing Process of Various Bone Graft Materials after Engraftment into the Human Body

1
School of Dentistry, Seoul National University, 101 Daehak-ro, Jongro-gu, Seoul 03080, Korea
2
Department of Oral and Maxillofacial Surgery, Section of Dentistry, Seoul National University Bundang Hospital, 82, Gumi-ro 173 Beon-gil, Bundang-gu, Seongnam city 13620, Gyeonggi-do, Korea
3
Department of Dentistry & Dental Research Institute, School of Dentistry, Seoul National University, Seoul 03080, Korea
4
Department of Conservative Dentistry, Section of Dentistry, Seoul National University Bundang Hospital, 82, Gumi-ro 173 Beon-gil, Bundang-gu, Seongnam city 13620, Gyeonggi-do, Korea
*
Authors to whom correspondence should be addressed.
Received: 3 April 2018 / Revised: 24 April 2018 / Accepted: 2 May 2018 / Published: 2 May 2018
(This article belongs to the Special Issue Bone Substitute Materials)
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Abstract

The purpose of this study was to measure the level of new bone formation induced by various bone graft materials to provide clinicians with more choices. The samples were divided into three groups: group 1 (n = 9: allograft + xenograft, DBX®, San Francisco, CA, USA + Bio-Oss®, Princeton, NJ, USA), group 2 (n = 10: xenograft, Bio-Oss®), and group 3 (n = 8: autogenous tooth bone graft, AutoBT®, Korea Tooth Bank, Seoul, Korea). The average duration of evaluation was 9.56, 2.50, and 3.38 months, respectively. A tissue sample was taken from 27 patients during the second implant surgery. New bone formation was measured via histomorphometry, using a charge-coupled device camera, adaptor, and image analysis software. Total bone area, total area, and ((total bone area/total area) × 100) was measured to determine the extent of new bone formation. The mean value of the total bone area was 152,232.63 μm2; the mean value of the total area was 1,153,696.46 μm2; and the mean total bone area/total area ratio was 13.50%. In each comparison, there was no significant difference among the groups; no inflammation or complications were found in any of the groups. AutoBT®, an autogenous tooth bone graft, resulted in a level of bone formation similar to that using allografts and xenografts. View Full-Text
Keywords: autogenous tooth bone graft; AutoBT®; allograft; DBX®; xenograft; Bio-Oss®; new bone formation autogenous tooth bone graft; AutoBT®; allograft; DBX®; xenograft; Bio-Oss®; new bone formation
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Jo, S.H.; Kim, Y.-K.; Choi, Y.-H. Histological Evaluation of the Healing Process of Various Bone Graft Materials after Engraftment into the Human Body. Materials 2018, 11, 714.

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