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Open AccessArticle

Type I Collagen and Strontium-Containing Mesoporous Glass Particles as Hybrid Material for 3D Printing of Bone-Like Materials

1
Politecnico di Torino, Department of Applied Science and Technology, Corso Duca degli Abruzzi 24, 10129 Torino, Italy
2
DIEF—Department of Industrial Engineering and RU INSTM, Università degli Studi di Firenze, Via S. Marta 3, 50139 Firenze, Italy
*
Author to whom correspondence should be addressed.
Materials 2018, 11(5), 700; https://doi.org/10.3390/ma11050700
Received: 29 March 2018 / Revised: 20 April 2018 / Accepted: 25 April 2018 / Published: 28 April 2018
(This article belongs to the Special Issue Selected papers from EUROMAT 2017 Conference—Biomaterials)
Bone tissue engineering offers an alternative promising solution to treat a large number of bone injuries with special focus on pathological conditions, such as osteoporosis. In this scenario, the bone tissue regeneration may be promoted using bioactive and biomimetic materials able to direct cell response, while the desired scaffold architecture can be tailored by means of 3D printing technologies. In this context, our study aimed to develop a hybrid bioactive material suitable for 3D printing of scaffolds mimicking the natural composition and structure of healthy bone. Type I collagen and strontium-containing mesoporous bioactive glasses were combined to obtain suspensions able to perform a sol-gel transition under physiological conditions. Field emission scanning electron microscopy (FESEM) analyses confirmed the formation of fibrous nanostructures homogeneously embedding inorganic particles, whereas bioactivity studies demonstrated the large calcium phosphate deposition. The high-water content promoted the strontium ion release from the embedded glass particles, potentially enhancing the osteogenic behaviour of the composite. Furthermore, the suspension printability was assessed by means of rheological studies and preliminary extrusion tests, showing shear thinning and fast material recovery upon deposition. In conclusion, the reported results suggest that promising hybrid systems suitable for 3D printing of bioactive scaffolds for bone tissue engineering have been developed. View Full-Text
Keywords: type I collagen; mesoporous bioactive glasses; bone tissue engineering; bioactive materials; hybrid systems; nanostructured materials; biomimicry type I collagen; mesoporous bioactive glasses; bone tissue engineering; bioactive materials; hybrid systems; nanostructured materials; biomimicry
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MDPI and ACS Style

Montalbano, G.; Fiorilli, S.; Caneschi, A.; Vitale-Brovarone, C. Type I Collagen and Strontium-Containing Mesoporous Glass Particles as Hybrid Material for 3D Printing of Bone-Like Materials. Materials 2018, 11, 700.

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