Next Article in Journal
A Tensile Specimen of Tailor Rolled Blanks with Equal Probability in Yield and Its Mechanical Behavior Analysis
Next Article in Special Issue
Type I Collagen and Strontium-Containing Mesoporous Glass Particles as Hybrid Material for 3D Printing of Bone-Like Materials
Previous Article in Journal
C60 Bioconjugation with Proteins: Towards a Palette of Carriers for All pH Ranges
Previous Article in Special Issue
Osteogenic Potential of Pre-Osteoblastic Cells on a Chitosan-graft-Polycaprolactone Copolymer
Open AccessArticle

Synthesis and Characterization of Silver-Doped Mesoporous Bioactive Glass and Its Applications in Conjunction with Electrospinning

1
Institute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, Cauerstraße 6, 91058 Erlangen, Germany
2
Institute of Biophysics, Department of Physics, University of Erlangen-Nuremberg, Henkestraße 91, 91052 Erlangen, Germany
*
Author to whom correspondence should be addressed.
Materials 2018, 11(5), 692; https://doi.org/10.3390/ma11050692
Received: 31 March 2018 / Revised: 19 April 2018 / Accepted: 20 April 2018 / Published: 28 April 2018
(This article belongs to the Special Issue Selected papers from EUROMAT 2017 Conference—Biomaterials)
Since they were first developed in 2004, mesoporous bioactive glasses (MBGs) rapidly captured the interest of the scientific community thanks to their numerous beneficial properties. MBGs are synthesised by a combination of the sol–gel method with the chemistry of surfactants to obtain highly mesoporous (pore size from 5 to 20 nm) materials that, owing to their high surface area and ordered structure, are optimal candidates for controlled drug-delivery systems. In this work, we synthesised and characterised a silver-containing mesoporous bioactive glass (Ag-MBG). It was found that Ag-MBG is a suitable candidate for controlled drug delivery, showing a perfectly ordered mesoporous structure ideal for the loading of drugs together with optimal bioactivity, sustained release of silver from the matrix, and fast and strong bacterial inhibition against both Gram-positive and Gram-negative bacteria. Silver-doped mesoporous glass particles were used in three electrospinning-based techniques to produce PCL/Ag-MBG composite fibres, to coat bioactive glass scaffolds (via electrospraying), and for direct sol electrospinning. The results obtained in this study highlight the versatility and efficacy of Ag-substituted mesoporous bioactive glass and encourage further studies to characterize the biological response to Ag-MBG-based antibacterial controlled-delivery systems for tissue-engineering applications. View Full-Text
Keywords: bioactive glass; ordered mesoporous glass; silver; antimicrobial; electrospinning; scaffolds bioactive glass; ordered mesoporous glass; silver; antimicrobial; electrospinning; scaffolds
Show Figures

Figure 1

MDPI and ACS Style

Ciraldo, F.E.; Liverani, L.; Gritsch, L.; Goldmann, W.H.; Boccaccini, A.R. Synthesis and Characterization of Silver-Doped Mesoporous Bioactive Glass and Its Applications in Conjunction with Electrospinning. Materials 2018, 11, 692.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop