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Materials 2018, 11(5), 692; https://doi.org/10.3390/ma11050692

Synthesis and Characterization of Silver-Doped Mesoporous Bioactive Glass and Its Applications in Conjunction with Electrospinning

1
Institute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, Cauerstraße 6, 91058 Erlangen, Germany
2
Institute of Biophysics, Department of Physics, University of Erlangen-Nuremberg, Henkestraße 91, 91052 Erlangen, Germany
*
Author to whom correspondence should be addressed.
Received: 31 March 2018 / Revised: 19 April 2018 / Accepted: 20 April 2018 / Published: 28 April 2018
(This article belongs to the Special Issue Selected papers from EUROMAT 2017 Conference—Biomaterials)
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Abstract

Since they were first developed in 2004, mesoporous bioactive glasses (MBGs) rapidly captured the interest of the scientific community thanks to their numerous beneficial properties. MBGs are synthesised by a combination of the sol–gel method with the chemistry of surfactants to obtain highly mesoporous (pore size from 5 to 20 nm) materials that, owing to their high surface area and ordered structure, are optimal candidates for controlled drug-delivery systems. In this work, we synthesised and characterised a silver-containing mesoporous bioactive glass (Ag-MBG). It was found that Ag-MBG is a suitable candidate for controlled drug delivery, showing a perfectly ordered mesoporous structure ideal for the loading of drugs together with optimal bioactivity, sustained release of silver from the matrix, and fast and strong bacterial inhibition against both Gram-positive and Gram-negative bacteria. Silver-doped mesoporous glass particles were used in three electrospinning-based techniques to produce PCL/Ag-MBG composite fibres, to coat bioactive glass scaffolds (via electrospraying), and for direct sol electrospinning. The results obtained in this study highlight the versatility and efficacy of Ag-substituted mesoporous bioactive glass and encourage further studies to characterize the biological response to Ag-MBG-based antibacterial controlled-delivery systems for tissue-engineering applications. View Full-Text
Keywords: bioactive glass; ordered mesoporous glass; silver; antimicrobial; electrospinning; scaffolds bioactive glass; ordered mesoporous glass; silver; antimicrobial; electrospinning; scaffolds
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Ciraldo, F.E.; Liverani, L.; Gritsch, L.; Goldmann, W.H.; Boccaccini, A.R. Synthesis and Characterization of Silver-Doped Mesoporous Bioactive Glass and Its Applications in Conjunction with Electrospinning. Materials 2018, 11, 692.

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