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Open AccessArticle

Effects of Prolonged Silver Nanoparticle Exposure on the Contextual Cognition and Behavior of Mammals

1
National Research Center “Kurchatov Institute”, 1 Akademika Kurchatova sq., Moscow 123182, Russia
2
Moscow Institute of Physics and Technologies (State University), 9 Institutskiy Lane, Moscow Region, Dolgoprudny 141701, Russia
3
Department of Physics, Lomonosov Moscow State University, 1-2 Leninskie Gory, Moscow 119991, Russia
*
Author to whom correspondence should be addressed.
Materials 2018, 11(4), 558; https://doi.org/10.3390/ma11040558
Received: 19 March 2018 / Revised: 31 March 2018 / Accepted: 3 April 2018 / Published: 5 April 2018
(This article belongs to the Special Issue Nanomaterials and Materials for Translational Research)
Silver nanoparticles have been widely used in the lighting and food industries, in medicine, and in pharmaceutics as an antiseptic agent. Recent research demonstrates that, after prolonged oral administration, silver nanoparticles may cross the blood-brain barrier and accumulate in the brain in rather high amounts. In ex vivo experiments, it has also been shown that silver nanoparticles demonstrate neurotoxicity. The objective of this work was to answer the questions whether silver nanoparticles change cognitive and behavioral functions of mammals after prolonged administration if silver nanoparticles have accumulated in the brain. C57Bl/6 male mice were orally exposed to PVP-coated silver nanoparticles daily for 30, 60, 120 and 180 days. Control mice were exposed to distilled water. After that they were tested in the Open Field, Elevated Plus Maze, Light-Dark Box and contextual fear conditioning task. The data have shown that the experimental mice went through three periods of switching in the behavior caused by adaptation to the toxic silver nanoparticles: anxiety, appearance of research instinct and impairment of long-term memory. This provides evidence of the hazardous effect of silver nanoparticles, which appears after long periods of silver nanoparticle oral administration. View Full-Text
Keywords: silver nanoparticles; behavioral functions; cognitive functions; mammals; open field; light-dark dox; elevated plus maze; contextual memory; accumulation in brain; neurotoxicity silver nanoparticles; behavioral functions; cognitive functions; mammals; open field; light-dark dox; elevated plus maze; contextual memory; accumulation in brain; neurotoxicity
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MDPI and ACS Style

Antsiferova, A.; Kopaeva, M.; Kashkarov, P. Effects of Prolonged Silver Nanoparticle Exposure on the Contextual Cognition and Behavior of Mammals. Materials 2018, 11, 558.

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