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Open AccessArticle

Toxicological Evaluation of Luminescent Silica Nanoparticles as New Drug Nanocarriers in Different Cancer Cell Lines

1
BIOSCOPE Group, [email protected], Chemistry Department, Faculty of Science and Technology, University NOVA of Lisbon, Caparica Campus, 2829-516 Caparica, Portugal
2
UCIBIO-REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy of the University of Porto, 4050-313 Porto, Portugal
3
Scientific and Technological Research Assistance Centre (CACTI), University of Vigo, 36310 Vigo, Spain
4
PROTEOMASS Scientific Society, Rua dos Inventores, Madam Parque, Caparica Campus, 2829-516 Caparica, Portugal
*
Author to whom correspondence should be addressed.
Materials 2018, 11(8), 1310; https://doi.org/10.3390/ma11081310
Received: 15 June 2018 / Revised: 25 July 2018 / Accepted: 25 July 2018 / Published: 28 July 2018
(This article belongs to the Special Issue Nanomaterials and Materials for Translational Research)
Luminescent mesoporous silica nanoparticles, [email protected]@PEG1, [email protected]@MNs and [email protected]@[email protected], were successfully synthetized and characterized by SEM, TEM, XRD, N2 nitrogen isotherms, 1H NMR, IR, absorption, and emission spectroscopy. Cytotoxic evaluation of these nanoparticles was performed in relevant in vitro cell models, such as human hepatoma HepG2, human brain endothelial (hCMEC/D3), and human epithelial colorectal adenocarcinoma (Caco-2) cell lines. None of the tested nanoparticles showed significant cytotoxicity in any of the three performed assays (MTT/NR/ LDH) compared with the respective solvent and/or coating controls, excepting for [email protected]@PEG1 nanoparticles, where significant toxicity was noticed in hCMEC/D3 cells. The results presented reveal that SiQDs-based mesoporous silica nanoparticles are promising nanoplatforms for cancer treatment, with a pH-responsive drug release profile and the ability to load 80% of doxorubicin. View Full-Text
Keywords: luminescence mesoporous silica nanoparticles; cytotoxicity; drug delivery luminescence mesoporous silica nanoparticles; cytotoxicity; drug delivery
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MDPI and ACS Style

Marcelo, G.; Ariana-Machado, J.; Enea, M.; Carmo, H.; Rodríguez-González, B.; Luis Capelo, J.; Lodeiro, C.; Oliveira, E. Toxicological Evaluation of Luminescent Silica Nanoparticles as New Drug Nanocarriers in Different Cancer Cell Lines. Materials 2018, 11, 1310.

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