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Open AccessArticle

3D Powder Printed Bioglass and β-Tricalcium Phosphate Bone Scaffolds

Department of Orthopedics and Trauma Surgery, Medical Center—Albert-Ludwigs-University of Freiburg, Faculty of Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Str. 55, 79106 Freiburg, Germany
School of Engineering, James Watt South Building, University of Glasgow, Glasgow G12 8QQ, UK
Institute for Manufacturing Technologies of Ceramic Components and Composites, University of Stuttgart, Allmandring 7b, D-70569 Stuttgart, Germany
FMF—Freiburg Materials Research Center, University of Freiburg, Stefan-Meier-Str. 21, D-79104 Freiburg, Germany
Interdisciplinary Center of Materials Science (CMAT), Martin Luther University Halle, Heinrich Damerow Str. 4, D-06120 Halle, Germany
Authors to whom correspondence should be addressed.
Materials 2018, 11(1), 13;
Received: 23 October 2017 / Revised: 18 December 2017 / Accepted: 18 December 2017 / Published: 22 December 2017
(This article belongs to the Special Issue Bone Substitute Materials)
The use of both bioglass (BG) and β tricalcium phosphate (β-TCP) for bone replacement applications has been studied extensively due to the materials’ high biocompatibility and ability to resorb when implanted in the body. 3D printing has been explored as a fast and versatile technique for the fabrication of porous bone scaffolds. This project investigates the effects of using different combinations of a composite BG and β-TCP powder for 3D printing of porous bone scaffolds. Porous 3D powder printed bone scaffolds of BG, β-TCP, 50/50 BG/β-TCP and 70/30 BG/β-TCP compositions were subject to a variety of characterization and biocompatibility tests. The porosity characteristics, surface roughness, mechanical strength, viability for cell proliferation, material cytotoxicity and in vitro bioactivity were assessed. The results show that the scaffolds can support osteoblast-like MG-63 cells growth both on the surface of and within the scaffold material and do not show alarming cytotoxicity; the porosity and surface characteristics of the scaffolds are appropriate. Of the two tested composite materials, the 70/30 BG/β-TCP scaffold proved to be superior in terms of biocompatibility and mechanical strength. The mechanical strength of the scaffolds makes them unsuitable for load bearing applications. However, they can be useful for other applications such as bone fillers. View Full-Text
Keywords: 3D printing; bone scaffolds; biocompatibility in vitro; bioglass; β-TCP 3D printing; bone scaffolds; biocompatibility in vitro; bioglass; β-TCP
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Seidenstuecker, M.; Kerr, L.; Bernstein, A.; Mayr, H.O.; Suedkamp, N.P.; Gadow, R.; Krieg, P.; Hernandez Latorre, S.; Thomann, R.; Syrowatka, F.; Esslinger, S. 3D Powder Printed Bioglass and β-Tricalcium Phosphate Bone Scaffolds. Materials 2018, 11, 13.

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