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Open AccessArticle

Genetically Engineered Phage Induced Selective H9c2 Cardiomyocytes Patterning in PDMS Microgrooves

by Youngjun Kim 1,3,*, Chunga Kwon 1,3 and Hojeong Jeon 2,3
1
Korea Institute of Science and Technology Europe (KIST-Europe) Forschungsgesellschaft mbH, Campus E 7 1, 66123 Saarbrücken, Germany
2
Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Hwarangno 14-gil 5, Seongbuk-gu, Seoul 136-791, Korea
3
Department of Biomedical Engineering, University of Science and Technology (UST), Daejeon 34113, Korea
*
Author to whom correspondence should be addressed.
Materials 2017, 10(8), 973; https://doi.org/10.3390/ma10080973
Received: 7 July 2017 / Revised: 1 August 2017 / Accepted: 9 August 2017 / Published: 21 August 2017
(This article belongs to the Special Issue Constitutive Modelling of Biological Tissues and Biomaterials)
A micro-patterned cell adhesive surface was prepared for future design of medical devices. One-dimensional polydimethylsiloxane (PDMS) micro-patterns were prepared by a photolithography process. Afterwards, recombinant filamentous phages that displayed a short binding motif with a cell adhesive peptide (-RGD-) on p8 proteins were immobilized on PDMS microgrooves through simple contact printing to study the cellular response of rat H9c2 cardiomyocyte. While the cell density decreased on PDMS micro-patterns, we observed enhanced cell proliferation and cell to surface interaction on the RGD-phage coated PDMS microgrooves. The RGD-phage coating also supported a better alignment of cell spreading rather than isotropic cell growths as we observed on non-pattered PDMS surface. View Full-Text
Keywords: polydimethylsiloxane (PDMS); micro-patterns; RGD-phage; cell-surface interaction; rat H9c2 cardiomyocytes polydimethylsiloxane (PDMS); micro-patterns; RGD-phage; cell-surface interaction; rat H9c2 cardiomyocytes
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Kim, Y.; Kwon, C.; Jeon, H. Genetically Engineered Phage Induced Selective H9c2 Cardiomyocytes Patterning in PDMS Microgrooves. Materials 2017, 10, 973.

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