Next Article in Journal
Synthesis of Magnetic Microspheres with Sodium Alginate and Activated Carbon for Removal of Methylene Blue
Next Article in Special Issue
Doped Calcium Silicate Ceramics: A New Class of Candidates for Synthetic Bone Substitutes
Previous Article in Journal
Cellulose Nanocrystals (CNCs) from Corn Stalk: Activation Energy Analysis
Previous Article in Special Issue
Physico-Chemical, In Vitro, and In Vivo Evaluation of a 3D Unidirectional Porous Hydroxyapatite Scaffold for Bone Regeneration
Article Menu
Issue 1 (January) cover image

Export Article

Open AccessFeature PaperArticle
Materials 2017, 10(1), 83;

Bioactive Glass Fiber-Reinforced PGS Matrix Composites for Cartilage Regeneration

CeRTEV—Center for Research, Technology and Education in Vitreous Materials, Vitreous Material Laboratory, Department of Materials Engineering, Universidade Federal de São Carlos—UFSCar, 13565905 São Carlos, SP, Brazil
Institute of Biomaterials, University of Erlangen-Nuremberg, 91058 Erlangen, Germany
Author to whom correspondence should be addressed.
Academic Editor: Enrico Bernardo
Received: 8 December 2016 / Revised: 12 January 2017 / Accepted: 13 January 2017 / Published: 20 January 2017
(This article belongs to the Special Issue Bioceramics 2016)
Full-Text   |   PDF [6716 KB, uploaded 20 January 2017]   |  


Poly(glycerol sebacate) (PGS) is an elastomeric polymer which is attracting increasing interest for biomedical applications, including cartilage regeneration. However, its limited mechanical properties and possible negative effects of its degradation byproducts restrict PGS for in vivo application. In this study, a novel PGS–bioactive glass fiber (F18)-reinforced composite was developed and characterized. PGS-based reinforced scaffolds were fabricated via salt leaching and characterized regarding their mechanical properties, degradation, and bioactivity in contact with simulated body fluid. Results indicated that the incorporation of silicate-based bioactive glass fibers could double the composite tensile strength, tailor the polymer degradability, and improve the scaffold bioactivity. View Full-Text
Keywords: poly(glycerol sebacate); bioactive glass; fibers; composite; cartilage; tissue engineering poly(glycerol sebacate); bioactive glass; fibers; composite; cartilage; tissue engineering

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Souza, M.T.; Tansaz, S.; Zanotto, E.D.; Boccaccini, A.R. Bioactive Glass Fiber-Reinforced PGS Matrix Composites for Cartilage Regeneration. Materials 2017, 10, 83.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Materials EISSN 1996-1944 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top