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Doped Calcium Silicate Ceramics: A New Class of Candidates for Synthetic Bone Substitutes

Biomaterials and Tissue Engineering Research Unit, School of AMME, University of Sydney, Sydney 2006, Australia
Author to whom correspondence should be addressed.
Academic Editor: Enrico Bernardo
Materials 2017, 10(2), 153;
Received: 29 December 2016 / Revised: 30 January 2017 / Accepted: 4 February 2017 / Published: 10 February 2017
(This article belongs to the Special Issue Bioceramics 2016)
Doped calcium silicate ceramics (DCSCs) have recently gained immense interest as a new class of candidates for the treatment of bone defects. Although calcium phosphates and bioactive glasses have remained the mainstream of ceramic bone substitutes, their clinical use is limited by suboptimal mechanical properties. DCSCs are a class of calcium silicate ceramics which are developed through the ionic substitution of calcium ions, the incorporation of metal oxides into the base binary xCaO–ySiO2 system, or a combination of both. Due to their unique compositions and ability to release bioactive ions, DCSCs exhibit enhanced mechanical and biological properties. Such characteristics offer significant advantages over existing ceramic bone substitutes, and underline the future potential of adopting DCSCs for clinical use in bone reconstruction to produce improved outcomes. This review will discuss the effects of different dopant elements and oxides on the characteristics of DCSCs for applications in bone repair, including mechanical properties, degradation and ion release characteristics, radiopacity, and biological activity (in vitro and in vivo). Recent advances in the development of DCSCs for broader clinical applications will also be discussed, including DCSC composites, coated DCSC scaffolds and DCSC-coated metal implants. View Full-Text
Keywords: calcium silicate; bioactive ceramic; synthetic bone substitute calcium silicate; bioactive ceramic; synthetic bone substitute
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No, Y.J.; Li, J.J.; Zreiqat, H. Doped Calcium Silicate Ceramics: A New Class of Candidates for Synthetic Bone Substitutes. Materials 2017, 10, 153.

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