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Volume 15
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10.3390/ph15091103
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Article

The Impact of Dietary Consumption of Palm Oil and Olive Oil on Lipid Profile and Hepatocyte Injury in Hypercholesterolemic Rats

by
Tarfa Albrahim
1,*,
Maram H. M. Alotaibi
1,
Norah M. M. Altamimi
1,
Atheer M. A. Albariqi
1,
Lamees A. O. Alqarni
1,
Sara N. A. Alassaf
1,
Hisham S. Aloudah
2,
Mohammed Alahmed
2,
Ahmad T. Almnaizel
2,
Maha R. Aldraihem
3 and
Mona Alonazi
3
1
Department of Health Sciences, Clinical Nutrition, College of Health and Rehabilitation Sciences, Princess Nourah Bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia
2
Prince Naif for Health Research Center, King Saud University, Riyadh 11472, Saudi Arabia
3
Department of Biochemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia
*
Author to whom correspondence should be addressed.
Pharmaceuticals 2022, 15(9), 1103; https://doi.org/10.3390/ph15091103
Submission received: 9 August 2022 / Revised: 26 August 2022 / Accepted: 29 August 2022 / Published: 4 September 2022
(This article belongs to the Special Issue Pharmacological Targets for the Treatment of Nonalcoholic Fatty Liver Disease)
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Abstract

A metabolic disease called hypercholesterolemia is connected to both oxidative damage and inflammation. The goal of the current investigation was to determine if olive oil and palm oil could prevent hypercholesterolemia-induced oxidative stress in the liver of rats fed a high-cholesterol diet (HCD). The experimental mice were given HCD for three months while also receiving 0.5 mL/kg of either palm or olive oil. Serum triglycerides, total cholesterol, LDL cholesterol, vLDL cholesterol, and the atherogenic index all significantly increased in HCD-fed rats, while HDL cholesterol significantly dropped. Additionally, HCD caused a notable rise in proinflammatory cytokines and serum transaminases in liver tissue. Additionally, HCD significantly increased the production of nitric oxide and lipid peroxidation in the liver while decreasing antioxidant enzymes. Treatment with palm and olive oils dramatically reduced the levels of pro-inflammatory cytokines and lipid peroxidation, improved antioxidant defenses, and considerably improved liver function indicators. Additionally, the examined oils dramatically decreased the expression of fatty acid synthase (FAS) in the liver of rats receiving HCD. In conclusion, HCD-fed rats exhibit significant antihyperlipidemic and cholesterol-lowering benefits from palm and olive oils. The improved antioxidant defenses, lower inflammation and lipid peroxidation, and altered hepatic FAS mRNA expression were the main mechanisms by which palm and olive oils produced their advantageous effects.
Keywords: palm oil; olive oil; hypercholesterolemia; oxidative stress; inflammation; FAS palm oil; olive oil; hypercholesterolemia; oxidative stress; inflammation; FAS

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MDPI and ACS Style

Albrahim, T.; Alotaibi, M.H.M.; Altamimi, N.M.M.; Albariqi, A.M.A.; Alqarni, L.A.O.; Alassaf, S.N.A.; Aloudah, H.S.; Alahmed, M.; Almnaizel, A.T.; Aldraihem, M.R.; et al. The Impact of Dietary Consumption of Palm Oil and Olive Oil on Lipid Profile and Hepatocyte Injury in Hypercholesterolemic Rats. Pharmaceuticals 2022, 15, 1103. https://doi.org/10.3390/ph15091103

AMA Style

Albrahim T, Alotaibi MHM, Altamimi NMM, Albariqi AMA, Alqarni LAO, Alassaf SNA, Aloudah HS, Alahmed M, Almnaizel AT, Aldraihem MR, et al. The Impact of Dietary Consumption of Palm Oil and Olive Oil on Lipid Profile and Hepatocyte Injury in Hypercholesterolemic Rats. Pharmaceuticals. 2022; 15(9):1103. https://doi.org/10.3390/ph15091103

Chicago/Turabian Style

Albrahim, Tarfa, Maram H. M. Alotaibi, Norah M. M. Altamimi, Atheer M. A. Albariqi, Lamees A. O. Alqarni, Sara N. A. Alassaf, Hisham S. Aloudah, Mohammed Alahmed, Ahmad T. Almnaizel, Maha R. Aldraihem, and et al. 2022. "The Impact of Dietary Consumption of Palm Oil and Olive Oil on Lipid Profile and Hepatocyte Injury in Hypercholesterolemic Rats" Pharmaceuticals 15, no. 9: 1103. https://doi.org/10.3390/ph15091103

APA Style

Albrahim, T., Alotaibi, M. H. M., Altamimi, N. M. M., Albariqi, A. M. A., Alqarni, L. A. O., Alassaf, S. N. A., Aloudah, H. S., Alahmed, M., Almnaizel, A. T., Aldraihem, M. R., & Alonazi, M. (2022). The Impact of Dietary Consumption of Palm Oil and Olive Oil on Lipid Profile and Hepatocyte Injury in Hypercholesterolemic Rats. Pharmaceuticals, 15(9), 1103. https://doi.org/10.3390/ph15091103

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