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Volume 15
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10.3390/ph15091102
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Article

The Antioxidant Role of Hemp Phytocomplex in Cannabis Oil-Based Extracts

by
Camillo Morano
1,
Michele Dei Cas
2,*,
Gabriella Roda
1,*,
Adalberto Fabbriconi
3,
Eleonora Casagni
1,
Marco Pallavicini
1,
Cristiano Bolchi
1,
Gloria Pallotti
4,
Francesco Romaniello
4 and
Pierangela Rovellini
4
1
Department of Pharmaceutical Sciences, Università degli Studi di Milano, 20133 Milan, Italy
2
Department of Health Sciences, Università degli Studi di Milano, 20142 Milan, Italy
3
Farmacia Bandi, 20127 Milan, Italy
4
INNOVHUB-SSI srl, 20133 Milan, Italy
*
Authors to whom correspondence should be addressed.
Pharmaceuticals 2022, 15(9), 1102; https://doi.org/10.3390/ph15091102
Submission received: 10 August 2022 / Revised: 30 August 2022 / Accepted: 1 September 2022 / Published: 4 September 2022
(This article belongs to the Topic Advances in Cannabinoid Research)
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Abstract

The therapeutic use of Cannabis oil extracts is constantly increasing. However, in Italy, they are allowed to be prepared with only a few methods and matrices. With this work, we aimed to assess how the different processes might affect the chemical composition of two different matrices (olive oils and medium chain triglycerides oils - MCT), accounting as variables for both the presence of Cannabis dried apices of the female flower and the adding of tocopherol acetate as an antioxidant. The macerated oils were prepared with four of the methods allowed according to the Italian legislation (Romano-Hazekamp, Cannazza-Citti, SIFAP and Calvi) and analyzed for normal and oxidized tocopherols, oxidized and conjugated fatty acids and volatile carbonyl compounds (VCCs), all using liquid chromatography coupled to UV or PDA detectors. According to our results, neither normal nor oxidized tocopherols are affected by the addition of antioxidants or Cannabis, while the oxidation state (according to the levels of oxidized and conjugated fatty acids) is often altered in either case. The VCCs concentrations, on the other hand, are never notably altered. These results suggest a worthless use of antioxidants in Cannabis macerated oils preparations, while the dried apices of female flowers might have a protective role in maintaining the oil oxidation state.
Keywords: cannabis; antioxidants; galenic formulas; olive oil; MCT cannabis; antioxidants; galenic formulas; olive oil; MCT

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MDPI and ACS Style

Morano, C.; Dei Cas, M.; Roda, G.; Fabbriconi, A.; Casagni, E.; Pallavicini, M.; Bolchi, C.; Pallotti, G.; Romaniello, F.; Rovellini, P. The Antioxidant Role of Hemp Phytocomplex in Cannabis Oil-Based Extracts. Pharmaceuticals 2022, 15, 1102. https://doi.org/10.3390/ph15091102

AMA Style

Morano C, Dei Cas M, Roda G, Fabbriconi A, Casagni E, Pallavicini M, Bolchi C, Pallotti G, Romaniello F, Rovellini P. The Antioxidant Role of Hemp Phytocomplex in Cannabis Oil-Based Extracts. Pharmaceuticals. 2022; 15(9):1102. https://doi.org/10.3390/ph15091102

Chicago/Turabian Style

Morano, Camillo, Michele Dei Cas, Gabriella Roda, Adalberto Fabbriconi, Eleonora Casagni, Marco Pallavicini, Cristiano Bolchi, Gloria Pallotti, Francesco Romaniello, and Pierangela Rovellini. 2022. "The Antioxidant Role of Hemp Phytocomplex in Cannabis Oil-Based Extracts" Pharmaceuticals 15, no. 9: 1102. https://doi.org/10.3390/ph15091102

APA Style

Morano, C., Dei Cas, M., Roda, G., Fabbriconi, A., Casagni, E., Pallavicini, M., Bolchi, C., Pallotti, G., Romaniello, F., & Rovellini, P. (2022). The Antioxidant Role of Hemp Phytocomplex in Cannabis Oil-Based Extracts. Pharmaceuticals, 15(9), 1102. https://doi.org/10.3390/ph15091102

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