Oncologic and Functional Outcomes of Salvage Robot-Assisted Radical Prostatectomy: Report of the First 10 Cases
Abstract
:1. Introduction
2. Materials and Methods
3. Results
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Median initial PSA, ng/mL (IQR) | 11.0 (6.61–12.4) |
Initial biopsy Gleason score, n (%) | |
3 + 3 | 2 (20) |
3 + 4 | 4 (40) |
4 + 3 | 1 (10) |
4 + 4 | 2 (20) |
5 + 5 | 1 (10) |
Initial definitive treatment, n (%) | |
IMRT with VMAT | 2 (20) |
IMRT with ADT (2 years) | 1 (10) |
SBRT | 1 (10) |
HIR with ADT (2 years) | 2 (10) |
LDR brachytherapy | 2 (20) |
HIFU | 2 (20) |
Median post-radiation PSA nadir, ng/mL (IQR) | 0.65 (0.48–0.88) |
History of ADT before sRARP *, n (%) | 6 (60) |
Median preoperative PSA, ng/mL (IQR) | 2.17 (1.64–2.79) |
Diagnosis of cancer at the prostate lesion prior to sRARP | |
Re-biopsy of the prostate | 7 |
Imaging test of the prostate (CT + MRI or 11C-choline PET) | 3 |
Diagnosis of metastasis prior to sRARP | |
CT + other imaging test (11C-choline PET, bone scintigram, 18F-FDG PET, DWIBS) | 6 |
11C-choline PET | 4 |
Median age at sRARP, years (IQR) | 71 (66–79) |
Median time since initial radiotherapy or focal therapy, months (IQR) | 89 (63–111) |
Median console time, min (IQR) | 136 (123–167) |
Median EBL, mL (IQR) | 100 (50–100) |
PLND, n (%) | 1 (10) |
Nerve-sparing, n (%) | 1 (10) |
Median catheterization time, days (IQR) | 7 (6–7) |
Median follow-up duration, months (IQR) | 13 (10–26) |
Major complication †, n (%) | |
Intraoperative | 0 (0) |
30-day | 0 (0) |
Total | 3 (30) |
Anastomotic stricture | 2 (20) |
Refractory osteomyelitis | 1 (10) |
Pathological T stage, n (%) | |
T2 | 6 (60) |
T3a | 2 (20) |
T3b | 2 (20) |
Pathological N+, n (%) | 1 (10) |
PSM, n (%) | 5 (50) |
Apex | 3 (30) |
Base | 1 (10) |
Apex and base | 1 (10) |
BCR, n (%) | 3 (30) |
Median time to sRARP since initial radiotherapy or focal therapy, months (IQR) | |
in BCR cases | 57 (45–81) |
in BCR-free cases | 103 (88–140) |
Cancer-specific survivor, n (%) | 10 (100) |
Erection, n (%) | 0 (0) |
Pad free or safety pad *, n (%) | 4 (40) |
HIFU | 2 (20) |
HIR | 1 (10) |
LDR | 1 (10) |
Median time to urinary continence, months (IQR) | 10 (9–10) |
Case Series | Kaffenberger [11] | Yuh [12] | Ogaya-Pinies [13] | Onol [14], § | Marconi [15] | Nathan [16] | Present Study | |
---|---|---|---|---|---|---|---|---|
Year | 2013 | 2014 | 2019 | 2019 | 2019 | 2021 | 2023 | |
N. | 34 | 51 | 96 | 94 | 32 | 82 | 135 | 10 |
Prior treatment (initial radiotherapy or focal therapy) | B, E, HF | B, E, P, HF Cr | B, E, HF, Cr, Cy | B, E, I, P | HF, Cr | F(A) | B, E, HF, Cr | B, I, S, HR, HF |
Age (years) | 67 | 68 | 66 | 65 | 66 | 65 | 70 | 71 |
Time to sRARP (months) * | 48.5 | 68 | 81.5 | 82.2 | 61.1 | NR | NR | 89 |
Operative time (min) | 176 | 179 | 125 | 129 | 122 | NR | 165 | 136 |
EBL (mL) | NR | 175 | 100 | 107 | 93 | 400 | 200 | 100 |
Catheter placement (days) | NR | 15 | 12 | 16 | 10 | NR | NR | 7 |
Continence rate (%) † | 39 ‡ | 45 | 57.3 | 45.7 ‡ | 84.4 ‡ | 83 | 80.7 | 40 |
Potency rate (%) † | 21 ‡ | 23 | 17.7 | 13 ‡ | 27 ‡ | 14 | 5.2 ‡ | 0 |
PSM (%) | 26 | 31.4 | 16.7 | 17 | 43.8 | 13 | 37.8 | 50 |
BCR-free survival rate (%) † | 82 | 57 ‡ | 84.4 | 64.9 ‡ | 68.8 ‡ | 74 | 68.1 | 70 |
Follow-up (months) | 16 | 36 | 14 | 32 | 29 | 24 | 17 | 13 |
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Oshina, T.; Yamada, Y.; Fujimura, T.; Taguchi, S.; Akiyama, Y.; Kamei, J.; Kaneko, T.; Kawai, T.; Obinata, D.; Yamada, D.; et al. Oncologic and Functional Outcomes of Salvage Robot-Assisted Radical Prostatectomy: Report of the First 10 Cases. Curr. Oncol. 2024, 31, 4762-4768. https://doi.org/10.3390/curroncol31080356
Oshina T, Yamada Y, Fujimura T, Taguchi S, Akiyama Y, Kamei J, Kaneko T, Kawai T, Obinata D, Yamada D, et al. Oncologic and Functional Outcomes of Salvage Robot-Assisted Radical Prostatectomy: Report of the First 10 Cases. Current Oncology. 2024; 31(8):4762-4768. https://doi.org/10.3390/curroncol31080356
Chicago/Turabian StyleOshina, Takahiro, Yuta Yamada, Tetsuya Fujimura, Satoru Taguchi, Yoshiyuki Akiyama, Jun Kamei, Tomoyuki Kaneko, Taketo Kawai, Daisuke Obinata, Daisuke Yamada, and et al. 2024. "Oncologic and Functional Outcomes of Salvage Robot-Assisted Radical Prostatectomy: Report of the First 10 Cases" Current Oncology 31, no. 8: 4762-4768. https://doi.org/10.3390/curroncol31080356
APA StyleOshina, T., Yamada, Y., Fujimura, T., Taguchi, S., Akiyama, Y., Kamei, J., Kaneko, T., Kawai, T., Obinata, D., Yamada, D., Fukuhara, H., Nakagawa, T., Takahashi, S., & Kume, H. (2024). Oncologic and Functional Outcomes of Salvage Robot-Assisted Radical Prostatectomy: Report of the First 10 Cases. Current Oncology, 31(8), 4762-4768. https://doi.org/10.3390/curroncol31080356