Dynamic Prediction of Overall Survival for Patients with Osteosarcoma: A Retrospective Analysis of the EURAMOS-1 Clinical Trial Data
Round 1
Reviewer 1 Report
Comments and Suggestions for AuthorsComments for author File: Comments.pdf
Author Response
Please see the attachment.
Author Response File: Author Response.pdf
Reviewer 2 Report
Comments and Suggestions for AuthorsThe authors have developed dynamic prediction of overall survival for patients with osteosarcoma using the EURAMOS-1 clinical trial data.
The topic is fashionable and interesting.
1) The authors categorized age into three groups. Can we see the 5-year death probabilities for children with different characteristics and disease status in addition to the adolescent model because the Child was a worse prognostic variable in this study?
2) I can't understand the situation of LR and NM. Were they developed simultaneously? If we use this prediction model, how do we treat LR and NM status?
3) I think the missing status for surgical margin should be excluded from the statistical analysis because the authors excluded the patients with missing tumor volume.
Author Response
Please see the attachment.
Author Response File: Author Response.pdf
Round 2
Reviewer 1 Report
Comments and Suggestions for Authorsit is a great work
suitable for publication