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Current Oncology
Volume 29
Issue 9
10.3390/curroncol29090502
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Article

The Diagnostic Value of PI-RADS v2.1 in Patients with a History of Transurethral Resection of the Prostate (TURP)

by
Jiazhou Liu
1,†,
Shihang Pan
2,†,
Liang Dong
1,†,
Guangyu Wu
2,
Jiayi Wang
1,
Yan Wang
1,
Hongyang Qian
1,
Baijun Dong
1,
Jiahua Pan
1,
Yinjie Zhu
1,* and
Wei Xue
1,*
1
Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
2
Department of Imaging, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
*
Authors to whom correspondence should be addressed.
†
These authors equally contributed to the study.
Curr. Oncol. 2022, 29(9), 6373-6382; https://doi.org/10.3390/curroncol29090502
Submission received: 28 July 2022 / Revised: 28 August 2022 / Accepted: 1 September 2022 / Published: 5 September 2022
(This article belongs to the Topic Prostate Cancer: Symptoms, Diagnosis & Treatment)
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Abstract

To explore the diagnostic value of the Prostate Imaging–Reporting and Data System version 2.1 (PI-RADS v2.1) for clinically significant prostate cancer (CSPCa) in patients with a history of transurethral resection of the prostate (TURP), we conducted a retrospective study of 102 patients who underwent systematic prostate biopsies with TURP history. ROC analyses and logistic regression analyses were performed to demonstrate the diagnostic value of PI-RADS v2.1 and other clinical characteristics, including PSA and free/total PSA (F/T PSA). Of 102 patients, 43 were diagnosed with CSPCa. In ROC analysis, PSA, F/T PSA, and PI-RADS v2.1 demonstrated significant diagnostic value in detecting CSPCa in our cohort (AUC 0.710 (95%CI 0.608–0.812), AUC 0.768 (95%CI 0.676–0.860), AUC 0.777 (95%CI 0.688–0.867), respectively). Further, PI-RADS v2.1 scores of the peripheral and transitional zones were analyzed separately. In ROC analysis, PI-RADS v2.1 remained valuable in identifying peripheral-zone CSPCa (AUC 0.780 (95%CI 0.665–0.854; p < 0.001)) while having limited capability in distinguishing transitional zone lesions (AUC 0.533 (95%CI 0.410–0.557; p = 0.594)). PSA and F/T PSA retain significant diagnostic value for CSPCa in patients with TURP history. PI-RADS v2.1 is reliable for detecting peripheral-zone CSPCa but has limited diagnostic value when assessing transitional zone lesions.
Keywords: prostate cancer; transurethral resection of the prostate; multiparametric magnetic resonance imaging; prostate-specific antigen prostate cancer; transurethral resection of the prostate; multiparametric magnetic resonance imaging; prostate-specific antigen

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MDPI and ACS Style

Liu, J.; Pan, S.; Dong, L.; Wu, G.; Wang, J.; Wang, Y.; Qian, H.; Dong, B.; Pan, J.; Zhu, Y.; et al. The Diagnostic Value of PI-RADS v2.1 in Patients with a History of Transurethral Resection of the Prostate (TURP). Curr. Oncol. 2022, 29, 6373-6382. https://doi.org/10.3390/curroncol29090502

AMA Style

Liu J, Pan S, Dong L, Wu G, Wang J, Wang Y, Qian H, Dong B, Pan J, Zhu Y, et al. The Diagnostic Value of PI-RADS v2.1 in Patients with a History of Transurethral Resection of the Prostate (TURP). Current Oncology. 2022; 29(9):6373-6382. https://doi.org/10.3390/curroncol29090502

Chicago/Turabian Style

Liu, Jiazhou, Shihang Pan, Liang Dong, Guangyu Wu, Jiayi Wang, Yan Wang, Hongyang Qian, Baijun Dong, Jiahua Pan, Yinjie Zhu, and et al. 2022. "The Diagnostic Value of PI-RADS v2.1 in Patients with a History of Transurethral Resection of the Prostate (TURP)" Current Oncology 29, no. 9: 6373-6382. https://doi.org/10.3390/curroncol29090502

APA Style

Liu, J., Pan, S., Dong, L., Wu, G., Wang, J., Wang, Y., Qian, H., Dong, B., Pan, J., Zhu, Y., & Xue, W. (2022). The Diagnostic Value of PI-RADS v2.1 in Patients with a History of Transurethral Resection of the Prostate (TURP). Current Oncology, 29(9), 6373-6382. https://doi.org/10.3390/curroncol29090502

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