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Current Oncology
Volume 29
Issue 9
10.3390/curroncol29090501
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Case Report

Growing Teratoma Syndrome with Synchronous Gliomatosis Peritonei during Chemotherapy in Ovarian Immature Teratoma: A Case Report and Literature Review

by
Sijian Li
1,
Na Su
2,
Congwei Jia
3,
Xinyue Zhang
1,
Min Yin
1 and
Jiaxin Yang
1,*
1
National Clinical Research Center for Obstetric and Gynecologic Diseases, Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730, China
2
Department of Ultrasound, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730, China
3
Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730, China
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2022, 29(9), 6364-6372; https://doi.org/10.3390/curroncol29090501
Submission received: 16 July 2022 / Revised: 31 August 2022 / Accepted: 2 September 2022 / Published: 4 September 2022
(This article belongs to the Section Gynecologic Oncology)
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Abstract

Coexistent growing teratoma syndrome (GTS) and gliomatosis peritonei (GP) arising during chemotherapy of ovarian immature teratoma (IMT) is extremely rare and can be misdiagnosed as recurrent or progressive disease. We present a 33-year-old woman diagnosed with GTS with synchronous GP during chemotherapy of IMT. She underwent ovarian cystectomy due to ovarian immature teratoma and chemotherapy were administered. The α-fetoprotein (AFP) concentration decreased from 28.7 ng/mL to normal after the second cycle. Four days after the third cycle of chemotherapy, ultrasound and CT revealed an 8-cm mass with negative tumor markers in the pouch of Douglas. An exploratory laparotomy was conducted, and a smooth round cystic-solid 8-cm mass was noted in the pouch of Douglas. Extensive peritoneal seeding glial nodules were also observed on the surface of the uterus, peritoneum, and omentum. The patient underwent a partial omentectomy, intact resection of the tumor, and resection of most of the glial nodules. Postoperative pathology demonstrated a pure mature cystic teratoma component in the mass, as well as diffuse GP involving the uterine serosa, peritoneum, and omentum; this diagnosis of GTS with synchorous GP should be considered in IMT patients with mass newly identified during chemotherapy while tumor markers are normal after treatment.
Keywords: ovarian tumors; immature teratoma; growing teratoma syndrome; gliomatosis peritonei; treatment ovarian tumors; immature teratoma; growing teratoma syndrome; gliomatosis peritonei; treatment

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MDPI and ACS Style

Li, S.; Su, N.; Jia, C.; Zhang, X.; Yin, M.; Yang, J. Growing Teratoma Syndrome with Synchronous Gliomatosis Peritonei during Chemotherapy in Ovarian Immature Teratoma: A Case Report and Literature Review. Curr. Oncol. 2022, 29, 6364-6372. https://doi.org/10.3390/curroncol29090501

AMA Style

Li S, Su N, Jia C, Zhang X, Yin M, Yang J. Growing Teratoma Syndrome with Synchronous Gliomatosis Peritonei during Chemotherapy in Ovarian Immature Teratoma: A Case Report and Literature Review. Current Oncology. 2022; 29(9):6364-6372. https://doi.org/10.3390/curroncol29090501

Chicago/Turabian Style

Li, Sijian, Na Su, Congwei Jia, Xinyue Zhang, Min Yin, and Jiaxin Yang. 2022. "Growing Teratoma Syndrome with Synchronous Gliomatosis Peritonei during Chemotherapy in Ovarian Immature Teratoma: A Case Report and Literature Review" Current Oncology 29, no. 9: 6364-6372. https://doi.org/10.3390/curroncol29090501

APA Style

Li, S., Su, N., Jia, C., Zhang, X., Yin, M., & Yang, J. (2022). Growing Teratoma Syndrome with Synchronous Gliomatosis Peritonei during Chemotherapy in Ovarian Immature Teratoma: A Case Report and Literature Review. Current Oncology, 29(9), 6364-6372. https://doi.org/10.3390/curroncol29090501

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