Review Reports

Round 1

Reviewer 1 Report

This is an interesting review about de-escalation strategies for human papillomavirus-associated oropharyngeal squamous cell carcinoma.

The paper is well written. References are adequate. Discussion is appropriate.

I think that the supplementary table should be included in the paper or the authors should include a table summarizing the results.

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 2 Report

The manuscript entitled “De-escalation strategies for human papillomavirus-associated oropharyngeal squamous cell carcinoma – Where are we now?” is an interesting review on the alternative therapy regimens or de-escalation strategies in HPV-positive OPSCC patients. The authors focused on the most recent advancements in this field. The study is on a timely subject in view of increasing interest about the quality of life of post-treatment HPV-positive OPSCC patients. I only suggest to briefly discuss the prognosis of HNSCC in young patients, comparing HPV-positive and HPV-negative cancers (for your convenience: doi: 10.1111/odi.13479).

Author Response

Please see the attachment.

Author Response File: Author Response.docx