Point of Care Molecular Testing: Community-Based Rapid Next-Generation Sequencing to Support Cancer Care
Abstract
:1. Introduction
2. Materials and Methods
2.1. Chart Review
2.2. Sequencing Studies
2.3. Specimen Handling and Work Flow
2.4. Turnaround Time Measurements
2.5. Single Gene Testing
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Gene | Alteration | No (%) | No (%) |
---|---|---|---|
KRAS | 116 (37%) | ||
G12C | 54 (17%) | ||
Other | 62 (20%) | ||
EGFR | 51 (16%) | ||
x19del | 26(8%) | ||
L858R | 20(6%) | ||
Other | 5 (2%) | ||
BRAF | 14 (5%) | ||
V600E | 4 (1%) | ||
Other | 10 (3%) | ||
ERBB2 | 10 (3%) | ||
Mutation | 7(2%) | ||
Amplification | 3(1%) | ||
MET | 13 (4%) | ||
x14skip | 10(3%) | ||
Amplification | 3(1%) | ||
ALK | 9 (3%) | ||
ROS-1 | 5 (2%) | ||
RET | 2 (1%) | ||
Other | 23 (7%) | ||
None identified | 66 (21%) | ||
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Sheffield, B.S.; Beharry, A.; Diep, J.; Perdrizet, K.; Iafolla, M.A.J.; Raskin, W.; Dudani, S.; Brett, M.A.; Starova, B.; Olsen, B.; et al. Point of Care Molecular Testing: Community-Based Rapid Next-Generation Sequencing to Support Cancer Care. Curr. Oncol. 2022, 29, 1326-1334. https://doi.org/10.3390/curroncol29030113
Sheffield BS, Beharry A, Diep J, Perdrizet K, Iafolla MAJ, Raskin W, Dudani S, Brett MA, Starova B, Olsen B, et al. Point of Care Molecular Testing: Community-Based Rapid Next-Generation Sequencing to Support Cancer Care. Current Oncology. 2022; 29(3):1326-1334. https://doi.org/10.3390/curroncol29030113
Chicago/Turabian StyleSheffield, Brandon S., Andrea Beharry, Joanne Diep, Kirstin Perdrizet, Marco A. J. Iafolla, William Raskin, Shaan Dudani, Mary Anne Brett, Blerta Starova, Brian Olsen, and et al. 2022. "Point of Care Molecular Testing: Community-Based Rapid Next-Generation Sequencing to Support Cancer Care" Current Oncology 29, no. 3: 1326-1334. https://doi.org/10.3390/curroncol29030113
APA StyleSheffield, B. S., Beharry, A., Diep, J., Perdrizet, K., Iafolla, M. A. J., Raskin, W., Dudani, S., Brett, M. A., Starova, B., Olsen, B., & Cheema, P. K. (2022). Point of Care Molecular Testing: Community-Based Rapid Next-Generation Sequencing to Support Cancer Care. Current Oncology, 29(3), 1326-1334. https://doi.org/10.3390/curroncol29030113