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Article

The Role of a Navigational Radiofrequency Ablation Device and Concurrent Vertebral Augmentation for Treatment of Difficult-to-Reach Spinal Metastases

1
Regional Referral Center for Oncologic Disease, Department of Oncological and Interventional Radiology, Businco Hospital, A.O. Brotzu, 09100 Cagliari, Italy
2
Institute for Global Health, UCL, Royal Free Campus Rowland Hill Street, London NW3 2PF, UK
3
Division of Nuclear Medicine, Businco Hospital, Regional Referral Center for Oncologic Disease, A.O. Brotzu, 09100 Cagliari, Italy
4
Unit of General Surgery, Department of Clinical and Experimental Medicine, University of Sassari, 07100 Sassari, Italy
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2021, 28(5), 4004-4015; https://doi.org/10.3390/curroncol28050340
Received: 17 September 2021 / Revised: 3 October 2021 / Accepted: 5 October 2021 / Published: 8 October 2021
(This article belongs to the Special Issue Treatment of Bone Metastasis)
Aims: The purpose of this study was to assess the effectiveness of a navigational radiofrequency ablation device with concurrent vertebral augmentation in the treatment of posterior vertebral body metastatic lesions, which are technically difficult to access. Primary outcomes of the study were evaluation of pain palliation and radiologic assessment of local tumor control. Materials and Methods: Thirty-five patients with 41 vertebral spinal metastases involving the posterior vertebral body underwent computed tomography-guided percutaneous targeted radiofrequency ablation, with a navigational radiofrequency ablation device, associated with vertebral augmentation. Twenty-one patients (60%) had 1 or 2 metastatic lesions (Group A) and fourteen (40%) patients had multiple (>2) vertebral lesions (Group B). Changes in pain severity were evaluated by visual analog scale (VAS). Metastatic lesions were evaluated in terms of radiological local control. Results: The procedure was technically successful in all the treated vertebrae. Among the symptomatic patients, the mean VAS score dropped from 5.7 (95% CI 4.9–6.5) before tRFA and to 0.9 (95% CI 0.4–1.3) after tRFA (p < 0.001). The mean decrease in VAS score between baseline and one week follow up was 4.8 (95% CI 4.2–5.4). VAS decrease over time between one week and one year following radiofrequency ablation was similar, suggesting that pain relief was immediate and durable. Neither patients with 1–2 vertebral metastases, nor those with multiple lesions, showed radiological signs of local progression or recurrence of the tumor in the index vertebrae during a median follow up of 19 months (4–46 months) and 10 months (4–37 months), respectively. Conclusion: Treatment of spinal metastases with a navigational radiofrequency ablation device and vertebral augmentation can be used to obtain local tumor control with immediate and durable pain relief, providing effective treatment in the multimodality management of difficult-to-reach spinal metastases. View Full-Text
Keywords: radiofrequency ablation; pain management; osseous metastasis; interventional oncology; vertebral augmentation radiofrequency ablation; pain management; osseous metastasis; interventional oncology; vertebral augmentation
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MDPI and ACS Style

Pusceddu, C.; De Francesco, D.; Melis, L.; Ballicu, N.; Fancellu, A. The Role of a Navigational Radiofrequency Ablation Device and Concurrent Vertebral Augmentation for Treatment of Difficult-to-Reach Spinal Metastases. Curr. Oncol. 2021, 28, 4004-4015. https://doi.org/10.3390/curroncol28050340

AMA Style

Pusceddu C, De Francesco D, Melis L, Ballicu N, Fancellu A. The Role of a Navigational Radiofrequency Ablation Device and Concurrent Vertebral Augmentation for Treatment of Difficult-to-Reach Spinal Metastases. Current Oncology. 2021; 28(5):4004-4015. https://doi.org/10.3390/curroncol28050340

Chicago/Turabian Style

Pusceddu, Claudio, Davide De Francesco, Luca Melis, Nicola Ballicu, and Alessandro Fancellu. 2021. "The Role of a Navigational Radiofrequency Ablation Device and Concurrent Vertebral Augmentation for Treatment of Difficult-to-Reach Spinal Metastases" Current Oncology 28, no. 5: 4004-4015. https://doi.org/10.3390/curroncol28050340

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