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Volume 28
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10.3390/curroncol28040268
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Article

Resection of Non-Functional Pancreatic Neuroendocrine Neoplasms—A Single-Center Retrospective Outcome Analysis

by
Kirsten Lindner
1,
Daniel Binte
1,
Jens Hoeppner
1,
Ulrich F. Wellner
1,
Dominik M. Schulte
2,
Sebastian M. Schmid
3,
Kim Luley
4,
Inga Buchmann
5,
Lars Tharun
6,
Tobias Keck
1,
Judith Gebauer
3 and
Birte Kulemann
1,7,*
1
Department of Surgery, University Medical Center of Schleswig-Holstein-Campus Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany
2
Division of Endocrinology, Diabetology and Clinical Nutrition, Department of Internal Medicine I, University Medical Center Schleswig-Holstein-Campus Kiel, 23538 Lübeck, Germany
3
Institute for Endocrinology and Diabetes, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany
4
Clinic for Hematology and Oncology, University Hospital Schleswig-Holstein-Campus Lübeck, 23538 Lübeck, Germany
5
Department of Radiology and Nuclear Medicine, University of Lübeck, Ratzeburger Alle 160, 23538 Lübeck, Germany
6
Institute of Pathology, University Medical Center of Schleswig-Holstein-Campus Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany
7
Faculty of Medicine, University of Freiburg, Hugstetter Str. 55, 79106 Freiburg, Germany
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2021, 28(4), 3071-3080; https://doi.org/10.3390/curroncol28040268
Submission received: 2 August 2021 / Revised: 7 August 2021 / Accepted: 8 August 2021 / Published: 11 August 2021
(This article belongs to the Section Gastrointestinal Oncology)
Versions Notes

Abstract

Surgery remains the only curative treatment of pancreatic neuroendocrine neoplasms (pNEN). Here, we report the outcome after surgery for non-functional pNEN at a European Neuroendocrine Tumor Society (ENETS) center in Germany between 2000 and 2019; cases were analyzed for surgical (Clavien–Dindo classification; CDc) and oncological outcomes. Forty-nine patients (tumor grading G1 n = 25, G2 n = 22, G3 n = 2), with a median age of 56 years, were included. Severe complications (CDc ≥ grade 3b) occurred in 11 patients (22.4%) and type B/C pancreatic fistulas (POPFs) occurred in 5 patients (10.2%); in-hospital mortality was 2% (n = 1). Six of seven patients with tumor recurrence (14.3%) had G2 tumors in the pancreatic body/tail. The median survival was 5.7 years (68 months; [1–228 months]). Neither the occurrence (p = 0.683) nor the severity of complications had an influence on the relapse behavior (p = 0.086). This also applied for a POPF (≥B, p = 0.609). G2 pNEN patients (n = 22) with and without tumor recurrence had similar median tumor sizes (4 cm and 3.9 cm, respectively). Five of the six relapsed G2 patients (83.3%) had tumor-positive lymph nodes (N+); all G2 pNEN patients with recurrence had initially been treated with distal pancreatic resection. Pancreatic resections for pNEN are safe but associated with relevant postoperative morbidity. Future studies are needed to evaluate suitable resection strategies for G2 pNEN.
Keywords: pancreatic neuroendocrine neoplasm; postoperative complications; pancreatic fistula; outcome; G2 pNEN pancreatic neuroendocrine neoplasm; postoperative complications; pancreatic fistula; outcome; G2 pNEN

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MDPI and ACS Style

Lindner, K.; Binte, D.; Hoeppner, J.; Wellner, U.F.; Schulte, D.M.; Schmid, S.M.; Luley, K.; Buchmann, I.; Tharun, L.; Keck, T.; et al. Resection of Non-Functional Pancreatic Neuroendocrine Neoplasms—A Single-Center Retrospective Outcome Analysis. Curr. Oncol. 2021, 28, 3071-3080. https://doi.org/10.3390/curroncol28040268

AMA Style

Lindner K, Binte D, Hoeppner J, Wellner UF, Schulte DM, Schmid SM, Luley K, Buchmann I, Tharun L, Keck T, et al. Resection of Non-Functional Pancreatic Neuroendocrine Neoplasms—A Single-Center Retrospective Outcome Analysis. Current Oncology. 2021; 28(4):3071-3080. https://doi.org/10.3390/curroncol28040268

Chicago/Turabian Style

Lindner, Kirsten, Daniel Binte, Jens Hoeppner, Ulrich F. Wellner, Dominik M. Schulte, Sebastian M. Schmid, Kim Luley, Inga Buchmann, Lars Tharun, Tobias Keck, and et al. 2021. "Resection of Non-Functional Pancreatic Neuroendocrine Neoplasms—A Single-Center Retrospective Outcome Analysis" Current Oncology 28, no. 4: 3071-3080. https://doi.org/10.3390/curroncol28040268

APA Style

Lindner, K., Binte, D., Hoeppner, J., Wellner, U. F., Schulte, D. M., Schmid, S. M., Luley, K., Buchmann, I., Tharun, L., Keck, T., Gebauer, J., & Kulemann, B. (2021). Resection of Non-Functional Pancreatic Neuroendocrine Neoplasms—A Single-Center Retrospective Outcome Analysis. Current Oncology, 28(4), 3071-3080. https://doi.org/10.3390/curroncol28040268

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