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Current Treatment Approaches and Outcomes in the Management of Rectal Cancer Above the Age of 80

Department of Surgery, The Wollongong Hospital, Wollongong, NSW 2500, Australia
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Curr. Oncol. 2021, 28(2), 1388-1401; https://doi.org/10.3390/curroncol28020132
Received: 25 January 2021 / Revised: 20 March 2021 / Accepted: 29 March 2021 / Published: 30 March 2021
Background: The number of cases of rectal cancer in our older cohort is expected to rise with our ageing population. In this study, we analysed patterns in treatment and the long-term outcomes of patients older than 80 years with rectal cancer across a health district. Methods: All cases of rectal cancer managed at the Illawarra Cancer Care Centre, Australia between 2006 and 2018 were analysed from a prospectively maintained database. Patients were stratified into three age groups: ≤65 years, 66–79 years and ≥80 years of age. The clinicopathological characteristics, operative and non-operative treatment approach and survival outcomes of the three groups were compared. Results: Six hundred and ninety-nine patients with rectal cancer were managed, of which 118 (17%) were aged 80 and above. Patients above 80 were less likely to undergo surgery (71% vs. 90%, p < 0.001) or receive adjuvant/neoadjuvant chemoradiotherapy (p < 0.05). Of those that underwent surgical resection, their tumours were on average larger (36.5 vs. 31.5 mm, p = 0.019) and 18 mm closer the anal verge (p = 0.001). On Kaplan–Meier analysis, those above 80 had poorer cancer-specific survival when compared to their younger counterparts (p = 0.032), but this difference was no longer apparent after the first year (p = 0.381). Conclusion: Patients above the age of 80 with rectal cancer exhibit poorer cancer-specific survival, which is accounted for in the first year after diagnosis. Priority should be made to optimise care during this period. There is a need for further research to establish the role of chemoradiotherapy in this population, which appears to be underutilised. View Full-Text
Keywords: rectal neoplasms; aged; radiotherapy; chemotherapy; surgery; survival rectal neoplasms; aged; radiotherapy; chemotherapy; surgery; survival
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MDPI and ACS Style

Mourad, A.P.; De Robles, M.S.; Putnis, S.; Winn, R.D.R. Current Treatment Approaches and Outcomes in the Management of Rectal Cancer Above the Age of 80. Curr. Oncol. 2021, 28, 1388-1401. https://doi.org/10.3390/curroncol28020132

AMA Style

Mourad AP, De Robles MS, Putnis S, Winn RDR. Current Treatment Approaches and Outcomes in the Management of Rectal Cancer Above the Age of 80. Current Oncology. 2021; 28(2):1388-1401. https://doi.org/10.3390/curroncol28020132

Chicago/Turabian Style

Mourad, Ali P.; De Robles, Marie S.; Putnis, Soni; Winn, Robert D.R. 2021. "Current Treatment Approaches and Outcomes in the Management of Rectal Cancer Above the Age of 80" Curr. Oncol. 28, no. 2: 1388-1401. https://doi.org/10.3390/curroncol28020132

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