A Study to Validate the Relevance of Semen F2-Isoprostanes on Human Male Infertility
Abstract
:1. Introduction
2. Materials and Methods
2.1. Patients
2.2. Light Microscopy
2.3. F2-IsoP Determination
2.4. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Vol (mL) | Sperm (106/mL) | Progressive Motility (%) | Rapid Motility (%) | Slow Motility (%) | Normal Morphology (%) | Viability (%) | F2-IsoPs (ng/mL) |
---|---|---|---|---|---|---|---|
4.00 (1.50) | 37.88 (68.98) | 29.00 (21.00) | 18.00 (20.00) | 10.00 (11.00) | 9.00 (9.00) | 70.00 (22.25) | 40.90 (44.64) |
Variable | Fertile Men (F, n = 45) | Idiopathic Infertility (I, n = 41) | Urogenital Infections (U, n = 52) | Varicocele (V, n = 54) | Statistics |
---|---|---|---|---|---|
Vol (mL) | 4.00 (1.30) | 4.00 (1.50) | 3.65 (1.15) | 4.00 (0.98) | |
Sperm (106/mL) | 110.00 (98.00) | 12.00 (31.90) | 24.50 (47.48) | 38.50 (31.56) | F vs. I, U, V. p < 0.001 I vs. U. p < 0.05 |
Progressive motility (%) | 51.00 (18.00) | 28.00 (15.00) | 23.00 (12.25) | 24.50 (16.75) | F vs. I, U, V. p < 0.001 |
Rapid motility (%) | 40.00 (10.00) | 20.00 (13.00) | 12.00 (12.25) | 12.00 (6.75) | F vs. I, U, V. p < 0.001 |
Slow motility (%) | 12.00 (11.00) | 8.00 (9.00) | 8.00 (8.50) | 12.00 (10.75) | F vs. I. p < 0.05 |
Normal morphology (%) | 15.00 (7.00) | 7.00 (5.00) | 6.00 (5.00) | 8.00 (5.00) | F vs. I, U, V. p < 0.001 |
Viability (%) | 85.00 (11.00) | 65.00 (20.00) | 60.00 (24.00) | 65.00 (16.50) | F vs. I, U, V. p < 0.001 |
F2-IsoPs (ng/mL) | 15.36 (14.41) | 22.80 (31.44) | 52.10 (24.62) | 66.40 (31.91) | F vs. U. p < 0.01 F vs. V. p < 0.001 |
Variable | Class 1 (<29.96 ng/mL) (n = 78) | Class 2 (>29.96 ng/mL) (n = 114) |
---|---|---|
Vol (mL) | 4.00 (1.50) | 4.00 (1.40) |
Sperm (106/mL) | 56.00 (98.43) | 25.00 (40.00) ** |
Progressive motility (%) | 40.00 (25.50) | 23.00 (17.00) *** |
Rapid motility (%) | 32.00 (19.00) | 12.00 (10.00) *** |
Slow motility (%) | 10.00 (13.00) | 10.00 (10.00) |
Normal morphology (%) | 12.00 (7.00) | 7.00 (6.00) * |
Viability (%) | 78.00 (20.00) | 64.00 (20.00) * |
F2-IsoPs (ng/mL) | 11.20 (14.93) | 59.80 (27.23) *** |
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Moretti, E.; Signorini, C.; Ferretti, F.; Noto, D.; Collodel, G. A Study to Validate the Relevance of Semen F2-Isoprostanes on Human Male Infertility. Int. J. Environ. Res. Public Health 2022, 19, 1642. https://doi.org/10.3390/ijerph19031642
Moretti E, Signorini C, Ferretti F, Noto D, Collodel G. A Study to Validate the Relevance of Semen F2-Isoprostanes on Human Male Infertility. International Journal of Environmental Research and Public Health. 2022; 19(3):1642. https://doi.org/10.3390/ijerph19031642
Chicago/Turabian StyleMoretti, Elena, Cinzia Signorini, Fabio Ferretti, Daria Noto, and Giulia Collodel. 2022. "A Study to Validate the Relevance of Semen F2-Isoprostanes on Human Male Infertility" International Journal of Environmental Research and Public Health 19, no. 3: 1642. https://doi.org/10.3390/ijerph19031642