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Article

The Role of Seminal Oxidative Stress Scavenging System in the Pathogenesis of Sperm DNA Damage in Men Exposed and Not Exposed to Genital Heat Stress

1
Institute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland
2
Clinic of Urology and Oncological Urology, Poznan University of Medical Sciences, 61-285 Poznan, Poland
3
Department of Histology and Developmental Biology, Pomeranian Medical University in Szczecin, 71-210 Szczecin, Poland
4
Department and Clinic Urology and Oncological Urology, Regional Specialist Hospital in Szczecin, 71-455 Szczecin, Poland
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The Fertility Partnership Vitrolive in Szczecin, 70-483 Szczecin, Poland
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Department of Clinical Immunology and Allergology, Danylo Halytskyy Lviv National Medical University, 79008 Lviv, Ukraine
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Department of Urology, Danylo Halytskyy Lviv National Medical University, 79010 Lviv, Ukraine
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Department of Paediatric Surgery, Danylo Halytskyy Lviv National Medical University, 79059 Lviv, Ukraine
*
Authors to whom correspondence should be addressed.
Academic Editor: Miroslawa Ferens-Sieczkowska
Int. J. Environ. Res. Public Health 2022, 19(5), 2713; https://doi.org/10.3390/ijerph19052713
Received: 14 December 2021 / Revised: 18 February 2022 / Accepted: 22 February 2022 / Published: 25 February 2022
Responding to the need for the verification of some experimental animal studies showing the involvement of oxidative stress in germ cell damage in the heat-induced testis, we investigated the possibility of a direct relationship between seminal oxidative stress markers (total antioxidant capacity, catalase activity, superoxide dismutase activity, and malondialdehyde concentration) and ejaculated sperm chromatin/DNA integrity (DNA fragmentation and chromatin condensation abnormalities) in distinct groups of men exposed and not exposed to prolonged scrotal hyperthermia. A statistical increase in the proportion of sperm with DNA fragmentation was observed in all the studied subgroups compared to the fertile men. In turn, the groups subjected to heat stress as professional drivers or infertile men with varicocele presented greater disturbances in the oxidative stress scavenging system than men not exposed to genital heat stress. Based on the comparative analysis of the studied parameters, we can conclude that alterations in the seminal oxidative stress scavenging system are directly engaged in the pathogenesis of ejaculated sperm DNA damage regardless of the intensity of the impact of thermal insult. To the best of our knowledge, this study, for the first time, revealed the co-existence of oxidative stress and sperm DNA damage in the semen of professional drivers. View Full-Text
Keywords: genital heat stress; oxidative stress scavenging system; sperm DNA damage genital heat stress; oxidative stress scavenging system; sperm DNA damage
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MDPI and ACS Style

Fraczek, M.; Lewandowska, A.; Budzinska, M.; Kamieniczna, M.; Wojnar, L.; Gill, K.; Piasecka, M.; Kups, M.; Havrylyuk, A.; Chopyak, V.; Nakonechnyy, J.; Nakonechnyy, A.; Kurpisz, M. The Role of Seminal Oxidative Stress Scavenging System in the Pathogenesis of Sperm DNA Damage in Men Exposed and Not Exposed to Genital Heat Stress. Int. J. Environ. Res. Public Health 2022, 19, 2713. https://doi.org/10.3390/ijerph19052713

AMA Style

Fraczek M, Lewandowska A, Budzinska M, Kamieniczna M, Wojnar L, Gill K, Piasecka M, Kups M, Havrylyuk A, Chopyak V, Nakonechnyy J, Nakonechnyy A, Kurpisz M. The Role of Seminal Oxidative Stress Scavenging System in the Pathogenesis of Sperm DNA Damage in Men Exposed and Not Exposed to Genital Heat Stress. International Journal of Environmental Research and Public Health. 2022; 19(5):2713. https://doi.org/10.3390/ijerph19052713

Chicago/Turabian Style

Fraczek, Monika, Angelika Lewandowska, Marta Budzinska, Marzena Kamieniczna, Lukasz Wojnar, Kamil Gill, Malgorzata Piasecka, Michal Kups, Anna Havrylyuk, Valentina Chopyak, Jozef Nakonechnyy, Andrij Nakonechnyy, and Maciej Kurpisz. 2022. "The Role of Seminal Oxidative Stress Scavenging System in the Pathogenesis of Sperm DNA Damage in Men Exposed and Not Exposed to Genital Heat Stress" International Journal of Environmental Research and Public Health 19, no. 5: 2713. https://doi.org/10.3390/ijerph19052713

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