Association of Age and Surgical Technique with the Quality of Life of Male Patients Treated for Abdominal Aorta Aneurysms: A Cross-Sectional Study
by
, , , and
Silvestra Barrena-Blázquez
1,*, 
Manuel Díez-Alonso
1,2,
Luis Felipe Riera del Moral
3,
Salvador Sanchez-Coll
3,
Melchor Alvarez-Mon
4,5,6
,
Miguel A. Ortega
4,5,† and
Fernando Ruiz-Grande
3,7,† 1
Department of General Surgery, Príncipe de Asturias Hospital, 28801 Alcalá de Henares, Spain
2
Department of Surgery, Medical and Social Sciences, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, Spain
3
Department of Vascular Surgery, Nuestra Señora del Rosario Hospital, 28834 Madrid, Spain
4
Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, Spain
5
Ramón y Cajal Institute of Sanitary Research (IRYCIS), 28034 Madrid, Spain
6
Immune System Diseases-Rheumatology and Internal Medicine Service, University Hospital Príncipe de Asturias, (CIBEREHD), 28806 Alcalá de Henares, Spain
7
Department of Vascular Surgery, Príncesa Hospital, 28834 Madrid, Spain
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Environ. Res. Public Health 2022, 19(11), 6580; https://doi.org/10.3390/ijerph19116580
Submission received: 3 April 2022
/
Revised: 23 May 2022
/
Accepted: 25 May 2022
/
Published: 28 May 2022
(This article belongs to the Special Issue Current Health Problems in Older Adults)
Abstract
:OBJECTIVES. The achievement of a good health-related quality of life (HRQoL) has become one of the primary objectives of medical–surgical interventions. The objective of this study is to determine the HRQoL of patients who underwent abdominal aortic aneurysm (AAA) surgery and to analyse the influence of age on HRQoL. MATERIALS AND METHODS. This is an observational cross-sectional study with 151 male patients who underwent an operation for AAAs between January 2013 and December 2020 in two hospital centres. HRQoL was assessed with the Spanish version of the 36-Item Short Form Survey (SF-36), starting in the month following the surgical intervention. Statistical analyses were performed using hypothesis tests and multivariate linear regression. RESULTS: The mean age of the patients was 73 years (SD: 7), and the mean interval between surgery and the interview was 37 months (SD: 27). The scores of the Physical Function (p = 0.001), Vitality (p = 0.016), Social Function (p = 0.014), and Mental Health (p = 0.007) dimensions of the SF-36 were significantly lower in the older age groups. In addition, the scores on the Physical Summary Component (p = 0.003) and the Mental Summary Component (p = 0.026) were significantly lower among individuals older than 70 years of age. The HRQoL in patients who underwent operations for AAAs was similar to that reported in the general population of Spain. Patients with an aorto-aortic shunt had better scores on the Physical Function (Beta: 10; p = 0.014) and Mental Health (Beta: 8.12; p = 0.040) dimensions than those who had an aorto-bi-iliac or bifemoral shunt, regardless of the age of the patients at operation. CONCLUSION: Among patients who underwent an operation for an AAA, there was a negative association between the age at operation and scores on the Physical Function, Vitality, Social Function, and Mental Health dimensions of the SF-36. The type of surgical technique influences the evolution of Physical Function and Mental Health scores, regardless of age.
1. Introduction
Abdominal aortic aneurysms (AAAs) are an important health problem due to their high frequency and severity. The prevalence of AAAs is 1.3% among men between 45–54 years of age and 12.5% among men between 75–84 years of age. The male-to-female ratio of AAAs is 4:1 [1]. The prevalence is positively associated with life expectancy and negatively associated with cardiovascular mortality. The most serious complication of an AAA is rupture, as it usually requires urgent surgical intervention and is associated with high mortality [2].
The treatment options and medical–surgical outcomes for AAAs are well known: medical treatment of cardiovascular comorbidities, open surgery with replacement by a prosthesis (OR), or implantation of an endoprosthesis (EVAR) [3]. The type of treatment is selected based on the size and morphology of the aneurysm, age, and comorbidities of the patient. OR has a morbidity and mortality ranging from 3–5% [2,4]. The initial morbidity and mortality of EVAR is lower (1–1.5%) and is usually indicated in patients with high surgical risk [5,6].
In recent years, it has been recognised that the objectives considered important for surgeons (morbidity, mortality, and long-term complications) can substantially differ, based on the patient’s perceived state of health after treatment [7,8]. Health-related quality of life (HRQoL) has become a prominent outcome measure and an aid for guiding patient expectations and decision making [7,8]. The 36-Item Short Form Survey Questionnaire (SF-36) is the most commonly used test to evaluate HRQoL in different arms of Medicine. It is generic, non-specific, and quantitative. A considerable amount of information has been published about the HRQoL of patients undergoing AAAs. Various authors have found a drop in all the parameters measured by the SF-36 questionnaire after surgical treatment of AAAs [9,10]. This drop is transient and the values of SF-36 return to preoperative levels after 6–12 months [11,12]. It is also known that age is negatively associated with all HRQoL indicators. However, few studies have analysed the long-term results of the SF-36 questionnaire in AAAs. Reported data indicate a progressive decrease in all the parameters of the SF-36 questionnaire, particularly those that reflect physical activity, as the age of the patients increases [13,14,15,16]. In addition, some publications have reported that patients treated by EVAR show a more marked decrease than OR patients [11,13]. Additionally, to date, studies have focused on middle-aged patients, and there are very few data on elderly patients [15,16]. Other specific health-related HRQoL instruments described to be used in vascular processes, such as the VascuQoL-6 questionnaire, have been used in peripheral arterial diseases and there is limited experience of AAAs [17]. Therefore, it is not known to what extent the age of the patient and the type of associated surgical intervention can influence HRQoL after the intervention. The objective of this study is to determine the influence of age and type of surgery on the HRQoL of patients with AAAs.
2. Materials and Methods
2.1. Design and Study Participants
Observational Cross-Sectional study. This study included patients who consecutively underwent treatment for AAAs between January 2013 and December 2020 at the Prince of Asturias University Hospital in Alcalá de Henares and at the Nuestra Señora del Rosario Hospital in Madrid. Patients undergoing scheduled, urgent, and preferential surgery were included. Patients with thoracic or thoracic-abdominal aneurysms and patients with occlusive involvement of the aorto-iliac sector were excluded. A cross-sectional survey on HRQoL after AAA surgical repair was conducted on patients who fulfilled the inclusion criteria by presenting the SF-36 questionnaire on quality of life and functional status. The results obtained for our patients were compared with the reference values of the Spanish version of the SF-36 for the population of males over 60 years old reported in a previous publication. The study adhered to the STROBE guidelines for designing and reporting cross-sectional observational studies [18].
Patients were identified from the computerised database that contains information about all patients who have undergone operations in the Vascular Surgery Unit. The study was approved by the Ethics Committee of the Prince of Asturias Hospital. The patients agreed to participate and signed the informed consent document.
Surgery was recommended when the aneurysm measured >5 cm in transverse diameter in the thoraco-abdominal-pelvic CT image performed with contrast; if the AAA growth was 1.5 times the reference value of the aortic diameter, or if the AAA expanded >0.5 cm/year; when it produced symptoms; or when symptoms of rupture were present. The choice of surgical technique—OR (laparotomy and implantation of aorto-aortic or aorto-bifemoral/bi-iliac prosthesis, according to the morphology of the vascular tree) or EVAR (implantation by minimally invasive route of an endoprosthesis with aorto-bi-iliac bypass)—was based on the preference of the surgeon and patient choice, although, in principle, EVAR was preferred in patients older than 70 years or with high surgical risk.
The clinical and demographic data of each patient were recorded in a computerised database in Microsoft Excel 2019 (v.19) R (Redmond, Washington, DC, USA). Data were collected on comorbidities, cardiovascular risk factors, aneurysm morphology, type of intervention, perioperative morbidity, mortality, and length of hospital stay.
2.2. Questionnaire SF-36
To determine the HRQoL, the validated Spanish version of the SF-36 questionnaire was used [18]. All patients were contacted by telephone to briefly inform them about the study and invite them to participate. All patients agreed to participate; the majority of them went to the hospital where an interview was conducted with the principal investigator. The investigator explained the objective of the study in detail, and the participants signed the informed consent form. Patients who could not travel to the hospital completed the questionnaire over the phone. All interviews were conducted between December 2019 and December 2020. A single survey was performed on all patients, and the time elapsed since the intervention was recorded.
The SF-36 consisted of 36 items that assessed 8 dimensions HRQoL: Body Pain (two items), Mental Health (5 items), Vitality (four items), Social Function (two items), General Health (five items), Physical Function (10 items), Emotional Role (three items), and Physical Role (four items). The scores obtained for each of the items were coded, aggregated, and transformed on a scale from 0 (worst health status) to 100 (best health status) according to the scoring and interpretation manual of the questionnaire [11]. The scores on these 8 dimensions were grouped into two Summary Measures: Mental Summary Component (Vitality, Social Function, Emotional Role, and Mental Health) and Physical Summary Component (Physical Function, Physical Role, Body Pain, and General Health).
2.3. Study Variables
The variables of main interest were the 8 dimensions of the SF-36 questionnaire. As potential confounders and effect modifiers, we considered the age of the patients when surgery was performed and the surgical technique. Variables of interest were collected for all participants.
2.4. Statistical Analysis
For each aspect of health included in the SF-36 test, the mean, median, percentiles (25, 50, 75), standard deviation, and proportion of individuals with the maximum (ceiling effect) and minimum (floor effect) scores were calculated.
For data analysis, patients were categorised into five-year age groups based on their age at the time of the intervention. The relationship between the SF-36 scores and the age of the patients was analysed in two ways. First, the results for our patients were compared with the reference values of the Spanish version of the SF-36 in the general population over 60 years old, published by López-García et al. [19]. This publication was based on a group of 3949 non-institutionalised subjects representative of the Spanish general population aged 60 years and over. Subjects were selected proportionally from all regions of Spain. The results of the SF-36 questionnaire were categorised by gender and age. We used ordinary least-squares adjustment to determine whether the trend of the association between the scores of the SF-36 dimensions and age was linear. Secondly, a linear regression analysis was performed for each of the health scales of the questionnaire: quality of life was taken as a dependent variable, surgical technique was taken as the independent variable, and age was included in the model as a covariate. The type of intervention was coded with the value 0 if it was an aorto-aortic bypass, and with the value of 1 if it was the aorto-bi-iliac or bifemoral bypass.
The Kruskal–Wallis test was used to compare the results of the SF-36 dimensions between the different age groups. Statistical Package for the Social Sciences (SPSS) (v.23) (IBM, Armonk, New York, USA) was used for statistical analyses.
3. Results
During the study period, 183 patients underwent surgery for AAAs: six women (2.7%) and 178 (97.3%) men. Of these, 112 were operated on with OR, and 70 with EVAR. Women were excluded for this study due to the reduced number of cases and to maintain homogeneity. In addition, between the intervention and the completion of this study, 18 patients (16.5%) in the OR group and 9 (13%) in the EVAR group died. Therefore, The HRQoL questionnaire was administered to the 151 male patients who remained alive: 93 (61.6%) in the OR group and 58 (38.4%) in the EVAR group. The mean age was 73 ± 7 years (median: 72 years, range: 94–48 years) (Table 1). The time interval between surgery and the interview was 37 months (SD: 27). Table 1 shows the scores of the eight SF-36 dimensions according to the age of the patients. The results of the Physical Role (p = 0.611), Body Pain (p = 0.210), and General Health (p = 0.119) dimensions were similar across age groups. The scores of the Emotional Role dimension were lower among older age groups, although the difference did not reach statistical significance (p = 0.059). In contrast, the scores of the Physical Function (p = 0.001), Vitality (p = 0.016), Social Function (p = 0.014), and Mental Health (p = 0.007) dimensions were significantly lower among older age groups (p for the linear trend p < 0.05). The results of the Physical and Mental Summary Component scores are shown in Table 2. Physical and Mental Summary Component scores were significantly lower in those older than 70 years of age (p = 0.003 and p = 0.026, respectively).
Table A4 of Appendix A shows the reference values of the Spanish version of the SF-36 in the population of Spanish males over 60 years of age, published by López-García et al. [19]. A decrease in scores was observed to be associated with the increasing age of the individuals in all dimensions except Mental Health (p for linear trend <0.001). The decrease is more pronounced for the Physical Function and Physical Role dimensions. A marked increase in the standard deviation of the means can also be observed in the scores of the older age groups.
When comparing the results of the two series, we observed higher average scores on the Physical Function and Body Pain dimensions among patients older than 70 years of age undergoing AAAs than among the control population. These patients also had lower scores for the Emotional Role dimension. However, the scores of all the health scales in our patients fell within the range of scores defined by the mean ± standard deviation described for the control population.
Linear regression revealed that the type of surgical technique was significantly associated with scores on the Physical Function (Beta: 10; p = 0.014) and Mental Health (Beta: 8.12; p = 0.040) dimensions (Table 3). Patients who underwent aorto-aortic bypass had higher scores than those who underwent aorto-bi-iliac or bifemoral bypass, regardless of the individual’s age at operation.
Figure 1 shows the mean scores of each of the dimensions of the SF-36 in patients undergoing AAAs and in the Spanish population used as a control group.
4. Discussion
In recent years, attention has been devoted to the subjective perceptions of patients regarding their physical and psychological well-being after treatment [7,8]. For patients, their symptoms are the main concern, regardless of whether the condition is serious [16]. HRQoL assessments provide a basis for a holistic view of the patient and complement the traditional outcomes of morbidity and mortality. In this study, we used the Spanish version of the SF-36 to measure HRQoL [19,20]. This is the most widely used generic instrument in the international literature for measuring HRQoL.
The data obtained contain a minimal proportion of lost information, since the response rate was 100%. The overall mean scores are located in most of the dimensions of the SF-36 in the most positive extremes of the scoring range, but in no case in the maximum value, which indicates that the patients are not free of perceived health problems. The data show a progressive and statistically significant decrease in the scores on the Physical Function (p = 0.001), Vitality (p = 0.016), Social Function (p = 0.014), and Mental Health (p = 0.007) dimensions as the age at operation increases. In addition, the scores of the Physical Summary Component and Mental Summary Component scores were significantly lower in the age groups over 70 years.
These results suggest a loss of functional capacity associated with increasing age. A difference of 5 points on any scale is considered clinically and socially relevant [21]. In our series, we found that, for the Physical Function dimension, the difference between the oldest and youngest groups was 25.19 points; for the Vitality dimension, it was 20.58; and for the Social Function dimension, it was 15.39 points. For mental health, the difference was 14.56 points, which quantifies the deterioration of HRQoL.
We compared the results of our series with the reference values of the Spanish version of the SF-36 among adult males over 60 years of age, published by López-García et al. [19]. In this control population, an increase in age is associated with a decrease in scores for all dimensions, except Mental Health. The decrease is more pronounced in the Physical Function and Physical Role dimensions and reflects the loss of functional capacity that accompanies progressive ageing; the Mental Component scores were affected in a milder way.
The results obtained in our sample are comparable to those of the control population, even though the scores of some dimensions are higher in our series. We found better results for the Body Pain dimension, in all age groups, and for the Physical Function dimension among patients in the groups between 60 and 64 years and between 70 and 79 years. We also found better results for the General Health dimension among patients between 70 and 79 years old and for the Mental Health dimension among octogenarian patients. In contrast, patients of all ages showed worse scores on the Emotional Role dimension, and patients in the groups between 60 and 64 years and 70 and 79 years showed worse scores for the Social Function dimension.
The observed differences cannot be attributed to the method of administering the questionnaire, as in the study by López-García et al. [19]. The interviews were conducted in person in the homes, and in our study, 90% of these were conducted in the hospital, with the remainder being conducted via telephone. A possible explanation for the observed differences can be found in the clinical elements of our study. It must be taken into account that our patients had gone through a serious life experience, which predictably led them to especially assess their situation after the surgical intervention. The scores of the questionnaire can reflect the benefits provided by the treatment. This fact has been previously verified for patients undergoing cardiac and cardiovascular surgery. In one study, the scores were compared before and after treatment, and it was found that patients showed higher scores after the intervention on three of the scales with the highest content of physical factors (physical function, physical role, and body pain) [22].
It is very interesting that not all the variation in the scores of the SF-36 dimensions was due to the effect of age, but that the surgical procedure also exerted a significant effect, especially in the Physical Function (Beta: 10; p = 0.014) and Mental Health (Beta: 8.12; p = 0.040) dimensions. Patients who underwent an aorto-aortic bypass tended to have higher scores than those who underwent an aorto-bi-iliac or bifemoral bypass, regardless of the age of the individuals. This finding is consistent with several previous studies that showed that, in the long term (more than one year after the intervention), patients who undergo surgery using the EVAR technique have a lower score on the Physical Function dimension and on the scales of the Summary Component, than patients who undergo OR [13,23,24,25]. The EVAR technique is usually indicated in patients with high surgical risk, but is associated with a high incidence of reoperations and long-term complications [5,6].
The SF-36 is the most commonly used tool to evaluate HRQoL. It is a generic test; it is not specific to a specific pathology and has been used in various processes. The validity of the results has been verified, and it is widely accepted. Its generic design allows an objective quantification of HRQoL that facilitates the description of results and the comparison with other series and the comparison with the values detected in control groups, representative of the general population of each country [25]. Some studies have questioned the usefulness of the SF-36 among older people, as older multimorbid vascular patients usually find it very hard answering all items of the SF-36. [26]. However, we noted a high degree of understanding of the questionnaire for the patients of our study and all participants completed all its items, which demonstrates that it is a useful instrument, especially when it is administered through a personal interview to a group of selected and motivated patients. It would be desirable to define a pragmatic, simple, and reliable way to evaluate patient-reported outcomes in standard care, as such a tool is missing in AAAs at this moment [27].
The main problem of the SF-36 is its relative complexity in processing the raw data provided by the patient. Therefore, simplified derivations of the test have been described, such as the SF-8, which seems to provide comparable results [28,29]. On the other hand, since it is a nonspecific test, it can lose information that could be captured by tests designed for specific pathologies. In the field of AAAs, specific tests have been described that allow us to obtain qualitative information on the degree of HRQoL [16,30]. However, their value has not been verified, and they also have a greater complexity of application and interpretation of results. Among the areas of content not included in the SF-36 is sexual dysfunction, which could have negatively affected the results in the Emotional Role scale of our group compared to the reference population.
The main limitation of this study is that no information on HRQoL was collected prior to surgery, and was only obtained at a specific time after surgery. This type of design is not capable of capturing the entire evolution of the patient. It would be very useful to perform a randomised study with longitudinal development in the collection of information.
5. Conclusions
In conclusion, patients who underwent an operation for AAAs show lower scores on the Physical Function, Vitality, Social Function, and Mental Health dimensions of HRQoL as the age at which they are operated on increases. The type of surgical technique performed has a significant effect on the Physical Function and Mental Health scores, independent of the effect of age.
Author Contributions
Conceptualization, S.B.-B., M.D.-A. and F.R.-G.; validation, S.B.-B., M.D.-A., L.F.R.d.M., S.S.-C., M.A.-M., M.A.O. and F.R.-G.; formal analysis, S.B.-B., M.D.-A. and F.R.-G.; investigation, S.B.-B., M.D.-A., L.F.R.d.M., S.S.-C., M.A.-M., M.A.O. and F.R.-G.; data curation, S.B.-B. and M.D.-A.; writing—original draft preparation, S.B.-B., M.D.-A., L.F.R.d.M., S.S.-C., M.A.-M., M.A.O. and F.R.-G.; writing—review and editing, S.B.-B., M.D.-A., L.F.R.d.M., S.S.-C., M.A.-M., M.A.O. and F.R.-G.; supervision, F.R.-G.; project administration, M.A.O.; funding acquisition, M.A.-M. and M.A.O. All authors have read and agreed to the published version of the manuscript.
Funding
This study (PI21/001244) was supported by the Instituto de Salud Carlos III (Plan Estatal de I + D + I 2013–2016) and co-financed by the European Development Regional Fund “A way to achieve Europe” (ERDF) and B2017/BMD-3804 MITIC-CM, B2020/MITICAD-CM and Halekulani S.L.
Institutional Review Board Statement
The study was conducted in accordance with the basic ethical principles of autonomy, beneficence, nonmaleficence and distributive justice, and its development followed the rules of Good Clinical Practice, the principles contained in the most recent Declaration of Helsinki (2013) and the Oviedo Convention (1997). The collected data and information complied with the current legislation on data protection (Organic Law 3/5 December 2018 on the Protection of Personal Data and the Guarantee of Digital Rights and Regulation (EU) 2016/679) approved by Hospital Universitario Principe de Asturias (0E17/2019).
Informed Consent Statement
Informed consent was obtained from all subjects involved in the study.
Data Availability Statement
The data used to support the findings of the present study are available from the corresponding author upon request.
Acknowledgments
We appreciate the comments and significant contributions of F. Rodriguez-Artalejo.
Conflicts of Interest
The authors declare no conflict of interest.
Appendix A
Table A1.
Characteristics of the operated patients and associated pathologies.
| OAR (n = 93) | EVAR (n = 58) | |
|---|---|---|
| Mean Age (SD) | 71 (7) | 76 (7) |
| Diabetes | 16 (17.4%) | 7 (12%) |
| Intermittent claudication | 3 (3.2%) | 1 (1.7%) |
| Lerich’s syndrome | 1 (1%) | 0 |
| Ischemic heart disease | 11 (11.8%) | 11 (15.9%) |
| ACVA | 2 (2.1%) | 5 (8.6%) |
| EPOC | 9 (9.6%) | 8 (13.7) |
| Chronic renal failure | 16 (17%) | 7 (12%) |
| Hyperuricemia | 5 (5.3%) | 0 |
| Hypothyroidism | 4 (4.6%) | 2 (3.4%) |
| Prostate pathology | 16 (17.2%) | 7 (12%) |
| SIZE OF THE ANEURISM | ||
| 40–56 mm | 41 (44%) | 24 (41.4%) |
| 57–73 mm | 28 (30%) | 33 (56%) |
| 73–90 mm | 10 (10.7%) | 1 (1.7%) |
| >90 mm | 14 (15%) | 0 |
| LOCATION | ||
| Juxta-pararenal | 15 (16%) | 0 |
| Infrarenals | 78 (84%) | 69 (100%) |
| TYPE OF DERIVATION | ||
| Bi-iliac aorto | 47 (50.5%) | 69 (100%) |
| Aorto-aortic | 31 (33.5%) | 0 |
| Bi-iliac-femoral aorto | 8 (8.7%) | 0 |
| Aorto-bifemoral | 7(7.2%) | 0 |
| HOSPITAL STAY days (average) | 10 (7) | 4.14 (4) |
Table A2.
Scores of the Health Scales of the SF-36 Questionnaire according to age groups.
| Age Groups | Physical Function | Physical Role | Body Pain | General Health | Vitality | Social Function | Emotional Role | Mental Health | |
|---|---|---|---|---|---|---|---|---|---|
| 60–64 (n = 24) | MEAN | 86.04 | 75.00 | 85.83 | 62.29 | 74.79 | 82.81 | 61.11 | 79.17 |
| SD | 12.50 | 36.11 | 19.09 | 20.79 | 19.64 | 24.11 | 12.69 | 19.94 | |
| RANK | 50–100 | 0–100 | 40–100 | 30–100 | 45–100 | 25–100 | 33–67 | 36–100 | |
| MEDIAN | 92.30 | 98.44 | 98.25 | 72.18 | 90.55 | 100.00 | 66.67 | 80.00 | |
| 65–69 (n = 22) | MEAN | 80.68 | 84.09 | 84.09 | 64.77 | 69.55 | 86.93 | 63.64 | 79.27 |
| SD | 21.50 | 29.42 | 26.12 | 16.65 | 16.54 | 22.65 | 9.808 | 21.96 | |
| RANK | 20–100 | 0–100 | 20–100 | 30–85 | 40–95 | 25–100 | 33–67 | 20–100 | |
| MEDIAN | 87.50 | 100.00 | 100.00 | 67.50 | 75.00 | 100.00 | 66.67 | 84.00 | |
| 70–74 (n = 37) | MEAN | 79.05 | 75.00 | 77.30 | 61.22 | 62.97 | 83.78 | 62.16 | 75.24 |
| SD | 20.16 | 36.79 | 20.36 | 19.05 | 23.13 | 22.60 | 11.55 | 23.92 | |
| RANK | 0–100 | 37–100 | 0–100 | 0–100 | 37–100 | 20–100 | 33–67 | 36–100 | |
| MEDIAN | 80.00 | 100.00 | 80.00 | 65.00 | 65.00 | 87.50 | 66.67 | 80.00 | |
| 75–79 (n = 35) | MEAN | 76.14 | 74.29 | 82.86 | 62.71 | 63.00 | 79.64 | 56.19 | 70.06 |
| SD | 22.75 | 38.10 | 25.61 | 18.60 | 22.10 | 27.30 | 17.66 | 20.38 | |
| RANK | 5–100 | 0–100 | 0–100 | 20–95 | 15–100 | 0–100 | 33–100 | 20–100 | |
| MEDIAN | 85.00 | 100.00 | 90.00 | 65.00 | 70.00 | 87.50 | 66.67 | 76.00 | |
| >80 (n = 33) | MEAN | 61.21 | 62.12 | 80.91 | 53.18 | 56.21 | 67.42 | 53.53 | 64.61 |
| SD | 24.11 | 44.68 | 25.78 | 17.62 | 19.76 | 27.23 | 20.31 | 19.80 | |
| RANK | 0–95 | 0–100 | 10–100 | 15–85 | 20–90 | 13–100 | 0–67 | 32–100 | |
| MEDIAN | 60.00 | 100.00 | 100.00 | 50.00 | 60.00 | 75.00 | 66.67 | 68.00 | |
| Total (n = 151) | MEAN | 75.83 | 73.34 | 81.72 | 60.50 | 64.34 | 79.55 | 58.94 | 72.93 |
| SD | 22.30 | 38.04 | 23.46 | 18.79 | 21.37 | 25.63 | 15.60 | 21.77 | |
| RANK | 0–100 | 0–100 | 0–100 | 15–100 | 5–100 | 0–100 | 0–100 | 20–100 | |
| MEDIAN | 80.00 | 100.00 | 90.00 | 65.00 | 65.00 | 87.50 | 66.67 | 80.00 | |
| p-value | 0.001 | 0.611 | 0.210 | 0.119 | 0.016 | 0.014 | 0.059 | 0.007 | |
Table A3.
Summary Measures according to the Age of Patients Operated on for AAAs.
| Age Groups | Physical Health | Mental Health | |
|---|---|---|---|
| 60–64 (n = 24) | MEAN | 38.1208 | 37.7604 |
| SD | 7.81883 | 7.78768 | |
| MEDIAN | 41.6146 | 40.1250 | |
| 65–69 (n = 22) | MEAN | 39.4176 | 37.2102 |
| SD | 8.30605 | 7.26060 | |
| MEDIAN | 43.8021 | 38.6875 | |
| 70–74 (n = 37) | MEAN | 37.5000 | 34.5912 |
| SD | 10.01091 | 8.93576 | |
| MEDIAN | 41.7708 | 37.0000 | |
| 75–79 (n = 35) | MEAN | 35.7827 | 34.8286 |
| SD | 9.98618 | 8.53244 | |
| MEDIAN | 38.6458 | 36.3750 | |
| >80 (n = 33) | MEAN | 30.5366 | 31.8636 |
| Total (n = 151) | SD | 11.78615 | 7.32420 |
| MEDIAN | 36.4583 | 34.0000 | |
| MEAN | 35.9582 | 34.9354 | |
| SD | 10.24146 | 8.24213 | |
| MEDIAN | 39.7917 | 36.2500 | |
| p-value. Kruskal–Wallis test | 0.003 | 0.026 | |
Table A4.
Scores of the SF-36 Health Questionnaire Scales by Age in the Control Population. Adapted from López-Garcia E (10).
Table A4.
Scores of the SF-36 Health Questionnaire Scales by Age in the Control Population. Adapted from López-Garcia E (10).
| Scales | Age (Years) | |||||
|---|---|---|---|---|---|---|
| 60–64 (n = 369) | 65–69 (n = 458) | 70–74 (n = 385) | 75–79 (n = 254) | 80–84 (n = 153) | 85 (n = 102) | |
| Physical Health | ||||||
| P5 | 25 | 25 | 10 | 5 | 10 | 0 |
| P25 | 70 | 70 | 60 | 50 | 30 | 30 |
| P50 | 90 | 90 | 80 | 80 | 60 | 60 |
| P75 | 95 | 95 | 90 | 90 | 85 | 85 |
| Mean (SD) | 78.9 (28.3) | 79.4 (27.0) | 73.3 (27.0) | 68.5 (29.8) | 57.0 (30.8) | 54.2 (34.5) |
| Physical Role | ||||||
| P5 | 0 | 0 | 0 | 0 | 0 | 0 |
| P25 | 100 | 100 | 75 | 75 | 25 | 0 |
| P50 | 100 | 100 | 100 | 100 | 100 | 100 |
| P75 | 100 | 100 | 100 | 100 | 100 | 100 |
| Mean (SD) | 85.0 (36.7) | 84.2 (39.1) | 77.5 (41.5) | 76.1 (41.9) | 71.0 (43.6) | 69.0 (50.5) |
| Body Pain | ||||||
| P5 | 22 | 22 | 22 | 22 | 12 | 21 |
| P25 | 61 | 62 | 61 | 61 | 42 | 51 |
| P50 | 100 | 84 | 84 | 74 | 80 | 74 |
| P75 | 100 | 100 | 100 | 100 | 100 | 100 |
| Mean (SD) | 78.8 (30.8) | 77.7 (30.0) | 75.3 (28.7) | 72.4 (27.5) | 71.2 (32.3) | 70.8 (30.8) |
| General Health | ||||||
| P5 | 25 | 25 | 20 | 20 | 25 | 15 |
| P25 | 45 | 47 | 45 | 40 | 40 | 40 |
| P50 | 65 | 65 | 60 | 57 | 55 | 57 |
| P75 | 77 | 77 | 72 | 72 | 67 | 72 |
| Mean (SD) | 61.3 (24.5) | 61.9 (24.3) | 59.0 (22.1) | 56.5 (21.8) | 55.1 (21.5) | 56.1 (26.1) |
| Vitality | ||||||
| P5 | 25 | 30 | 25 | 25 | 20 | 10 |
| P25 | 55 | 60 | 50 | 45 | 40 | 45 |
| P50 | 70 | 75 | 70 | 65 | 60 | 60 |
| P75 | 85 | 90 | 85 | 80 | 80 | 80 |
| Mean (SD) | 68.6 (25.2) | 71.0 (25.5) | 66.5 (23.4) | 63.4 (24.9) | 58.5 (25.9) | 59.0 (29.5) |
| Social Function | ||||||
| P5 | 37.5 | 37.5 | 25 | 25 | 12.5 | 0 |
| P25 | 87.5 | 87.5 | 75 | 75 | 62.5 | 50 |
| P50 | 100 | 100 | 100 | 100 | 100 | 87.5 |
| P75 | 100 | 100 | 100 | 100 | 100 | 100 |
| Emotional Role | ||||||
| P5 | 0 | 0 | 0 | 0 | 0 | 0 |
| P25 | 100 | 100 | 100 | 100 | 100 | 100 |
| P50 | 100 | 100 | 100 | 100 | 100 | 100 |
| P75 | 100 | 100 | 100 | 100 | 100 | 100 |
| Mean (SD) | 92.4 (27.9) | 91.4 (29.8) | 92.1 (25.9) | 89.6 (28.2) | 87.6 (31.8) | 83.1 (39.7) |
| Mental Health | ||||||
| P5 | 36 | 40 | 44 | 36 | 36 | 32 |
| P25 | 64 | 64 | 64 | 60 | 64 | 64 |
| P50 | 80 | 80 | 76 | 76 | 72 | 80 |
| P75 | 92 | 92 | 88 | 92 | 88 | 96 |
| Mean (SD) | 75.8 (22.1) | 77.1 (23.7) | 74.8 (19.3) | 73.3 (21.4) | 72.8 (19.7) | 76.3 (24.1) |
References
- Altobelli, E.; Rapacchietta, L.; Profeta, V.F.; Fagnano, R. Risk factors for abdominal aortic aneurysm in population-based studies: A systematic review and meta-analysis. Int. J. Environ. Res. Public Health 2018, 15, 2805. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Moll, F.L.; Powell, J.T.; Fraedrich, G.; Verzini, F.; Haulon, S.; Waltham, M.; van Herwaarden, J.A.; Holt, P.J.E.; van Keulen, J.W.; Rantner, B.; et al. Management of abdominal aortic aneurysms clinical practice guidelines of the European society for vascular surgery. Eur. J. Vasc. Endovasc. Surg. 2011, 41, S1–S58. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Kent, K.C.; Zwolak, R.M.; Jaff, M.R.; Hollenbeck, S.T.; Thompson, R.W.; Schermerhorn, M.L.; Sicard, G.A.; Riles, T.S.; Cronenwett, J.L. Screening for abdominal aortic aneurysm: A consensus statement. (Document de Consensus sur le Dépistage des Anévrysmes de l’Aorte Abdominale). J. Vasc. Surg. 2004, 39, 267–269. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Wanhainen, A.; Verzini, F.; Van Heerzeele, I.; Allaire, E.; Bown, M.; Cohnert, T.; Dick, F.; van Herwaarden, J.; Karkos, C.; Koelemay, M.; et al. Editor´s Choice- European Society for Vascular Surgery (ESVS) 2019 Clinical Practice Guideliness on the Management of Abdominal Aorto-iliac Artery Aneurysms. Eur. J. Vasc. Endovassc. Surg. 2019, 57, 8–93. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Stather, P.W.; Sidloff, D.; Dattani, N.; Choke, E.; Bown, M.J.; Sayers, R.D. Systematic review and meta-analysis of the early and late outcomes of open and endovascular repair of abdominal aortic aneurysm. Br. J. Surg. 2013, 100, 863–872. [Google Scholar] [CrossRef]
- IMPROVE Trial Investigators. Endovascular strategy or open repair for ruptured abdominal aortic aneurysm: One year outcomes from the IMPROVE randomized trial. Eur. Hearth J. 2015, 36, 2061–2069. [Google Scholar] [CrossRef] [Green Version]
- Hamming, J.F.; De Vries, J. Measuring quality of life. Br. J. Surg. 2007, 94, 923–924. [Google Scholar] [CrossRef]
- Urbach, D.R. Measuring quality of life after surgery. Surg. Innov. 2005, 12, 161–165. [Google Scholar] [CrossRef]
- Lederle, F.A.; Freischlag, A.; Kyriakides, T.C.; Padberg, F.T.; Matsumura, J.S.; Kohler, T.R.; Lin, P.H.; Jean-Claude, J.M.; Cikrit, D.F.; for the Open Versus Endovascular Repair (OVER) Veterans Affairs Cooperative Study Group; et al. Outcomes Following Endovascular vs. Open Repair of Abdominal Aortic Aneurysm. A Randomized Trial. JAMA 2009, 302, 1535–1542. [Google Scholar] [CrossRef] [Green Version]
- Pettersson, M.E.; Berghom, L. Life is about so much more: Patients’ experiences of health, well-being, and recovery after operation of abdominal aortic aneurysm with open and endovascular treatment—A prospective study. J. Vasc. Nurs. 2019, 37, 160–168. [Google Scholar] [CrossRef]
- EVAR Trial Participants. Endovascular aneurysm repair versus open repair in patients with abdominal aortic aneurysm (EVAR trial 1): Randomized controlled trial. Lancet 2005, 365, 2179–2186. [Google Scholar] [CrossRef]
- Kayssi, A.; DeBord, A.; Roche-Nagle, G.; Nguyen, L.L. Health-related quality-of-life outcomes after open versus endovascular abdominal aortic aneurysm repair. J. Vasc. Surg. 2015, 62, 491–498. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Yildirim, H.; van Lammeren, G.W.; Ünlü, Ç.; van Dongen, E.P.; van de Mortel, R.H.; de Vries, J.P. Long-term outcome and quality of life after ruptured abdominal aortic aneurysm repair. Vascular 2018, 26, 231–238. [Google Scholar] [CrossRef] [PubMed]
- Hinterseher, I.; Kuffner, H.; Berth, H.; Gabel, G.; Botticher, G.; Detlev Saeger, H.; Smelser, D. Long-Term Quality of Life of Abdominal Aortic Aneurysm Patients Under Surveillance or After Operative Treatment. Ann. Vasc. Surg. 2013, 27, 553–561. [Google Scholar] [CrossRef] [PubMed]
- Dick, F.; Grobety, V.; Immer, F.F.; Do, D.; Savolainen, H.; Carrel, T.P.; Schmidli, J. Outcome and Quality of Life in patients treated for abdominal aortic aneurysms: A single center experience. World J. Surg. 2008, 32, 987–994. [Google Scholar] [CrossRef] [PubMed]
- Shan, L.; Saxena, A.; Goh, D.D.; Robinson, D. A systematic review on the quality of life and functional status after abdominal aortic aneurysm repair in elderly patients with an average age of older than 75 years. J. Vasc. Surg. 2019, 69, 1268–1281. [Google Scholar] [CrossRef] [PubMed]
- Nordanstig, J.; Wann-Hansson, C.; Karlsson, J.; Lundstrom, M.; Pettersson, M.; Morgan, M. Vascular Quality of Life Questionnaire-6 facilitates health-related quality of life assessment in peripheral arterial disease. J. Vasc. Surg. 2014, 59, 700–707. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Strobe Statement.org. Strengthening the Reporting of Observational Studies in Epidemiology. Available online: https://www.strobe-statement.org/checklists (accessed on 12 January 2022).
- López-García, E.; Banegas, J.R.; Pérez-Regadera, A.G.; Gutiérrez-Fisac, J.L.; Alonso, J.; Rodríguez-Artalejo, F. Valores de referencia de la versión española del Cuestionario de Salud SF-36 en población adulta de más de 60 años. Med. Clín. 2003, 120, 568–573. [Google Scholar] [CrossRef]
- Alonso, J. Manual de Puntuación de la Versión Española del Cuestionario SF-36; Institut Municipal d’Investigació Mèdica (IMIM): Barcelona, Spain, 2000. [Google Scholar]
- Ware, J.; Snow, K.K.; Kosinski, M.; Gandek, B. SF-36 Health Survey: Manual and Interpretation Guide; The Health Institute, New England Medical Center: Boston, MA, USA, 1993; pp. 10.16–10.17. [Google Scholar]
- Phillips, R.; Lansky, D. Outcomes management in heart valve replacement surgery: Early experience. J. Heart Valve Dis. 1992, 1, 42–50. [Google Scholar]
- Peach, G.; Holt, P.; Loftus, I.; Thompson, M.M.; Hinchliffe, R. Questions remain about quality of life after abdominal aortic aneurysm repair. J. Vasc. Surg. 2012, 56, 520–527. [Google Scholar] [CrossRef] [Green Version]
- De Bruin, J.L.; Groenwold, R.H.H.; Baas, A.F.; Brownrigg, J.R.; Prinssen, M.; Grobbee, D.E.; y BlanKensteijn, J.D.; for the DREAM Study Group. Quality of life from a randomized trial of open and endovascular repair for abdominal aortic aneurysm. Br. J. Surg. 2016, 103, 995–1002. [Google Scholar] [CrossRef] [PubMed]
- Jean-Baptiste, E.; Brizzi, S.; Bartoli, M.A.; Sadaghianloo, N.; Baque, J.; Magnan, P.E.; Hassen-Khodja, R. Pelvic ischemia and quality of life scores after interventional occlusion of the hypogastric artery in atients undergoing endovascular aortic aneurysm repair. J. Vasc. Surg. 2014, 60, 40–49. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Hayes, V.; Morris, J.; Wolfe, C.; Morgan, M. The SF-36 health survey questionnaire: Is it suitable for use with older adults? Age Ageing 1995, 24, 120–125. [Google Scholar] [CrossRef] [PubMed]
- Duncan, R.; Essat, M.; Jones, G.; Booth, A.; Buckley Woods, H.; Poku, E.; Kaltenthaler, E.; Keetharuth, A.D.; Palfreyman, S.; Michaels, J. Systematic review and qualitative evidence synthesis of patient-reported outcome measures for abdominal aortic aneurysm. Br. J. Surg. 2017, 104, 317–327. [Google Scholar] [CrossRef] [PubMed]
- Ware, J.E.; Sherbourne, C.D. The MOS 36-item short form health survey (SF-36). Med. Care 1992, 30, 473–483. [Google Scholar] [CrossRef] [PubMed]
- Kato, T.; Tamaki, M.; Tsunekawa, T.; Motoji, Y.; Hirakawa, A.; Okawa, Y.; Tomita, S. Health-related quality of life prospectively evaluated by the 8-item short form after endovascular repair versus open surgery for abdominal aortic aneurysm. Heart Vessels 2017, 32, 960–968. [Google Scholar] [CrossRef] [PubMed]
- Ruth, M.A.; Hamming, J.F.; van Schaik, J.; Lindeman, J. Towards Patient Centred Outcomes for Elective Abdominal Aortic Aneurysm Repair: A Scoping Review of Quality of Life Scales. Eur. J. Vasc. Endovasc. Surg. 2021, 62, 630–641. [Google Scholar]
Figure 1.
Mean scores in each of the dimensions of the SF-36 in patients operated on for abdominal aortic aneurysms (AAAs) and the general Spanish population (control).
Figure 1.
Mean scores in each of the dimensions of the SF-36 in patients operated on for abdominal aortic aneurysms (AAAs) and the general Spanish population (control).
Table 1.
Scores of the Health Scales of the SF-36 questionnaire according to age groups.
| Age Groups | Physical Function | Physical Role | Body Pain | General Health | Vitality | Social Function | Emotional Role | Mental Health | |
|---|---|---|---|---|---|---|---|---|---|
| 60–64 (n = 24) | MEAN | 86.04 | 75.00 | 85.83 | 62.29 | 74.79 | 82.81 | 61.11 | 79.17 |
| SD | 12.50 | 36.11 | 19.09 | 20.79 | 19.64 | 24.11 | 12.69 | 19.94 | |
| 65–69 (n = 22) | MEAN | 80.68 | 84.09 | 84.09 | 64.77 | 69.55 | 86.93 | 63.64 | 79.27 |
| SD | 21.50 | 29.42 | 26.12 | 16.65 | 16.54 | 22.65 | 9.808 | 21.96 | |
| 70–74 (n = 37) | MEAN | 79.05 | 75.00 | 77.30 | 61.22 | 62.97 | 83.78 | 62.16 | 75.24 |
| SD | 20.16 | 36.79 | 20.36 | 19.05 | 23.13 | 22.60 | 11.55 | 23.92 | |
| 75–79 (n = 35) | MEAN | 76.14 | 74.29 | 82.86 | 62.71 | 63.00 | 79.64 | 56.19 | 70.06 |
| SD | 22.75 | 38.10 | 25.61 | 18.60 | 22.10 | 27.30 | 17.66 | 20.38 | |
| >80 (n = 33) | MEAN | 61.21 | 62.12 | 80.91 | 53.18 | 56.21 | 67.42 | 53.53 | 64.61 |
| SD | 24.11 | 44.68 | 25.78 | 17.62 | 19.76 | 27.23 | 20.31 | 19.80 | |
| Total (n = 151) | MEAN | 75.83 | 73.34 | 81.72 | 60.50 | 64.34 | 79.55 | 58.94 | 72.93 |
| SD | 22.30 | 38.04 | 23.46 | 18.79 | 21.37 | 25.63 | 15.60 | 21.77 | |
| p-value | 0.001 | 0.611 | 0.210 | 0.119 | 0.016 | 0.014 | 0.059 | 0.007 | |
Table 2.
Summary Measures according to the Age of Patients Operated on for AAAs.
| Age Groups | Physical Health | Mental Health | |
|---|---|---|---|
| 60–64 (n = 24) | MEAN | 38.1208 | 37.7604 |
| SD | 7.81883 | 7.78768 | |
| 65–69 (n = 22) | MEAN | 39.4176 | 37.2102 |
| SD | 8.30605 | 7.26060 | |
| 70–74 (n = 37) | MEAN | 37.5000 | 34.5912 |
| SD | 10.01091 | 8.93576 | |
| 75–79 (n = 35) | MEAN | 35.7827 | 34.8286 |
| SD | 9.98618 | 8.53244 | |
| >80 (n = 33) | MEAN | 30.5366 | 31.8636 |
| Total (n = 151) | SD | 11.78615 | 7.32420 |
| MEAN | 35.9582 | 34.9354 | |
| SD | 10.24146 | 8.24213 | |
| p-value. Kruskal–Wallis test | 0.003 | 0.026 | |
Table 3.
Linear regression analysis of the relationship between age and surgical procedure with the score on the quality of life scales (SF-36) of patients operated on for abdominal aortic aneurysm.
Table 3.
Linear regression analysis of the relationship between age and surgical procedure with the score on the quality of life scales (SF-36) of patients operated on for abdominal aortic aneurysm.
| Beta | p-Value | |
|---|---|---|
| Physical Health | 146 | 0 |
| Constant | 10.1 | 0.014 |
| Surgical Procedure | ||
| Age | −0.99 | 0 |
| Physical Role | 125 | 0 |
| Constant | 4.66 | 0.544 |
| Surgical Procedure | ||
| Age | −0.09 | 0.081 |
| Body Pain | 86.5 | 0 |
| Constant | 4.66 | 0.839 |
| Surgical Procedure | ||
| Age | −0.72 | 0.791 |
| General Health | 81.6 | 0 |
| Constant | 6.13 | 0.105 |
| Surgical Procedure | ||
| Age | −0.069 | 0.134 |
| Vitality | 114 | 0 |
| Constant | 5.84 | 0.163 |
| Surgical Procedure | ||
| Age | –0.70 | 0.002 |
| Social Function | 127 | 0 |
| Constant | 9.06 | 0.074 |
| Surgical Procedure | ||
| Age | −0.67 | 0.014 |
| Emotional Role | 87.8 | 0 |
| Constant | −0.91 | 0.771 |
| Surgical Procedure | ||
| Age | −0.39 | 0.023 |
| Mental Health | 114 | 0 |
| Constant | 8.12 | 0.04 |
| Surgical Procedure | ||
| Age | −0.58 | 0.012 |
Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. |
© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Share and Cite
MDPI and ACS Style
Barrena-Blázquez, S.; Díez-Alonso, M.; Riera del Moral, L.F.; Sanchez-Coll, S.; Alvarez-Mon, M.; Ortega, M.A.; Ruiz-Grande, F. Association of Age and Surgical Technique with the Quality of Life of Male Patients Treated for Abdominal Aorta Aneurysms: A Cross-Sectional Study. Int. J. Environ. Res. Public Health 2022, 19, 6580. https://doi.org/10.3390/ijerph19116580
AMA Style
Barrena-Blázquez S, Díez-Alonso M, Riera del Moral LF, Sanchez-Coll S, Alvarez-Mon M, Ortega MA, Ruiz-Grande F. Association of Age and Surgical Technique with the Quality of Life of Male Patients Treated for Abdominal Aorta Aneurysms: A Cross-Sectional Study. International Journal of Environmental Research and Public Health. 2022; 19(11):6580. https://doi.org/10.3390/ijerph19116580
Chicago/Turabian StyleBarrena-Blázquez, Silvestra, Manuel Díez-Alonso, Luis Felipe Riera del Moral, Salvador Sanchez-Coll, Melchor Alvarez-Mon, Miguel A. Ortega, and Fernando Ruiz-Grande. 2022. "Association of Age and Surgical Technique with the Quality of Life of Male Patients Treated for Abdominal Aorta Aneurysms: A Cross-Sectional Study" International Journal of Environmental Research and Public Health 19, no. 11: 6580. https://doi.org/10.3390/ijerph19116580
Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.
