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Volume 18
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Review

Real-World Utilization of Target- and Immunotherapies for Lung Cancer: A Scoping Review of Studies Based on Routinely Collected Electronic Healthcare Data

by
Andrea Spini
1,2,*,
Giulia Hyeraci
3,
Claudia Bartolini
3,
Sandra Donnini
4,*,
Pietro Rosellini
5,6,
Rosa Gini
3,
Marina Ziche
2,
Francesco Salvo
1,6 and
Giuseppe Roberto
3
1
INSERM, BPH, U1219, Team Pharmacoepidemiology, University of Bordeaux, 33000 Bordeaux, France
2
Department of Medical Science, Surgery and Neuroscience, University of Siena, 53100 Siena, Italy
3
Osservatorio di Epidemiologia, Agenzia Regionale di Sanità Della Toscana, 50141 Florence, Italy
4
Department of Life Sciences, University of Siena, 53100 Siena, Italy
5
CIC1401, CIC Bordeaux, 33000 Bordeaux, France
6
Pole de Santé Publique, Service de Pharmacologie Médicale, Centre de Pharmacovigilance de Bordeaux, CHU de Bordueax, 33000 Bordeaux, France
*
Authors to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2021, 18(14), 7679; https://doi.org/10.3390/ijerph18147679
Submission received: 27 April 2021 / Revised: 14 July 2021 / Accepted: 15 July 2021 / Published: 19 July 2021
(This article belongs to the Special Issue Real-World Data for Health Research: The Potential of Longitudinal Data Mining)
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Abstract

Routinely collected electronic healthcare data (rcEHD) have a tremendous potential for enriching pre-marketing evidence on target- and immunotherapies used to treat lung cancer (LC). A scoping review was performed to provide a structured overview of available rcEHD-based studies on this topic and to support the execution of future research by facilitating access to pertinent literature both for study design and benchmarking. Eligible studies published between 2016 and 2020 in PubMed and ISI Web of Science were searched. Data source and study characteristics, as well as evidence on drug utilization and survival were extracted. Thirty-two studies were included. Twenty-six studies used North American data, while three used European data only. Thirteen studies linked ≥1 data source types among administrative/claims data, cancer registries and medical/health records. Twenty-nine studies retrieved cancer-related information from medical records/cancer registries and 31 studies retrieved information on drug utilization or survival from medical records or administrative/claim data. Most part of studies concerned non-small-cell-LC patients (29 out of 32) while none focused on small-cell-LC. Study cohorts ranged between 85 to 81,983 patients. Only two studies described first-line utilization of immunotherapies. Results from this review will serve as a starting point for the execution of future rcEHD-based studies on innovative LC pharmacotherapies.
Keywords: electronic healthcare data; big data; real-word data; real-word evidence; drug utilization; lung cancer; immunotherapy; target-therapy; scoping review electronic healthcare data; big data; real-word data; real-word evidence; drug utilization; lung cancer; immunotherapy; target-therapy; scoping review

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MDPI and ACS Style

Spini, A.; Hyeraci, G.; Bartolini, C.; Donnini, S.; Rosellini, P.; Gini, R.; Ziche, M.; Salvo, F.; Roberto, G. Real-World Utilization of Target- and Immunotherapies for Lung Cancer: A Scoping Review of Studies Based on Routinely Collected Electronic Healthcare Data. Int. J. Environ. Res. Public Health 2021, 18, 7679. https://doi.org/10.3390/ijerph18147679

AMA Style

Spini A, Hyeraci G, Bartolini C, Donnini S, Rosellini P, Gini R, Ziche M, Salvo F, Roberto G. Real-World Utilization of Target- and Immunotherapies for Lung Cancer: A Scoping Review of Studies Based on Routinely Collected Electronic Healthcare Data. International Journal of Environmental Research and Public Health. 2021; 18(14):7679. https://doi.org/10.3390/ijerph18147679

Chicago/Turabian Style

Spini, Andrea, Giulia Hyeraci, Claudia Bartolini, Sandra Donnini, Pietro Rosellini, Rosa Gini, Marina Ziche, Francesco Salvo, and Giuseppe Roberto. 2021. "Real-World Utilization of Target- and Immunotherapies for Lung Cancer: A Scoping Review of Studies Based on Routinely Collected Electronic Healthcare Data" International Journal of Environmental Research and Public Health 18, no. 14: 7679. https://doi.org/10.3390/ijerph18147679

APA Style

Spini, A., Hyeraci, G., Bartolini, C., Donnini, S., Rosellini, P., Gini, R., Ziche, M., Salvo, F., & Roberto, G. (2021). Real-World Utilization of Target- and Immunotherapies for Lung Cancer: A Scoping Review of Studies Based on Routinely Collected Electronic Healthcare Data. International Journal of Environmental Research and Public Health, 18(14), 7679. https://doi.org/10.3390/ijerph18147679

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