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Review

The Effects of Exercise on BDNF Levels in Adolescents: A Systematic Review with Meta-Analysis

1
Post-Graduate Program in Public Health, Federal University of Rio Grande do Norte, 59078-970 Natal, Brazil
2
Department of Sociosanitary Sciences, University of Murcia, 30100 Murcia, Spain
3
Faculty of Nursing, Catholic University of Murcia (UCAM), 30107 Murcia, Spain
4
Center for Research in Sport, Health and Human Development, University of Trás-os-Montes and Alto Douro, 5001-801 Vila Real, Portugal
5
Post-Graduate Program in Health and Society, State University of Rio Grande do Norte (UERN), 59610-210 Mossoró, Brazil
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2020, 17(17), 6056; https://doi.org/10.3390/ijerph17176056
Received: 8 June 2020 / Revised: 4 July 2020 / Accepted: 10 July 2020 / Published: 20 August 2020
The aim of this study was to analyze the evidence available in the literature about the effects of exercise on brain-derived neurotrophic factor levels in adolescents. The literature searches were conducted in PubMed, Embase, Scopus, ScienceDirect, Web of Science, SportDiscus, the Cochrane Central Register of Controlled Trials (CENTRAL) and CINAHL. Randomized controlled trials and non-randomized controlled trials performed with adolescents (10–19 years) who underwent different exercise programs and who evaluated BDNF levels before and after the intervention were included. We included six studies, four RCTs and two non-RCTs in the systematic review with a total of 407 adolescents. In two randomized trials and one non-RCT, the intervention groups showed significant improvements in BDNF levels compared with the control group. The results presented in the meta-analysis indicate that despite the positive effect in favor of the intervention, there were no significant differences (standardized mean difference 0.28 ng/mL, 95% confidence interval −0.28 to 0.85; p = 0.32, I² = 0%). The results presented in our review indicate that aerobic exercise programs practiced in moderate- or high-intensity are promising strategies to increase BDNF levels in adolescents. However, further studies are required to support this finding. View Full-Text
Keywords: exercise; brain-derived neurotrophic factor; BDNF; adolescent; systematic review; meta-analysis exercise; brain-derived neurotrophic factor; BDNF; adolescent; systematic review; meta-analysis
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MDPI and ACS Style

Azevedo, K.P.M.d.; de Oliveira, V.H.; Medeiros, G.C.B.S.d.; Mata, Á.N.d.S.; García, D.Á.; Martínez, D.G.; Leitão, J.C.; Knackfuss, M.I.; Piuvezam, G. The Effects of Exercise on BDNF Levels in Adolescents: A Systematic Review with Meta-Analysis. Int. J. Environ. Res. Public Health 2020, 17, 6056. https://doi.org/10.3390/ijerph17176056

AMA Style

Azevedo KPMd, de Oliveira VH, Medeiros GCBSd, Mata ÁNdS, García DÁ, Martínez DG, Leitão JC, Knackfuss MI, Piuvezam G. The Effects of Exercise on BDNF Levels in Adolescents: A Systematic Review with Meta-Analysis. International Journal of Environmental Research and Public Health. 2020; 17(17):6056. https://doi.org/10.3390/ijerph17176056

Chicago/Turabian Style

Azevedo, Kesley P.M.d., Victor H. de Oliveira, Gidyenne C.B.S.d. Medeiros, Ádala N.d.S. Mata, Daniel Á. García, Daniel G. Martínez, José C. Leitão, Maria I. Knackfuss, and Grasiela Piuvezam. 2020. "The Effects of Exercise on BDNF Levels in Adolescents: A Systematic Review with Meta-Analysis" International Journal of Environmental Research and Public Health 17, no. 17: 6056. https://doi.org/10.3390/ijerph17176056

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