Next Article in Journal
Relationship Between Knowledge and Types of Attitudes Towards People Living with Dementia
Previous Article in Journal
Risk of Kidney Injury among Construction Workers Exposed to Heat Stress: A Longitudinal Study from Saudi Arabia
Article

Anticholinergic Burden and Safety Outcomes in Older Patients with Chronic Hepatitis C: A Retrospective Cohort Study

1
Pharmacy Service Hospital Clínic de Barcelona, 08036 Barcelona, Spain
2
Pharmacy Service Division of Medicines Hospital Clínic de Barcelona, University of Barcelona, IDIBAPS, 08036 Barcelona, Spain
3
School of Health Sciences Blanquerna, University Ramon Llull, 08025 Barcelona, Spain
4
Liver Unit Hospital Clínic de Barcelona, University of Barcelona, IDIBAPS, 08036 Barcelona, Spain
5
Centro de Investigación Biomédica Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 28029 Madrid, Spain
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2020, 17(11), 3776; https://doi.org/10.3390/ijerph17113776
Received: 29 March 2020 / Revised: 15 May 2020 / Accepted: 21 May 2020 / Published: 26 May 2020
(This article belongs to the Section Health Communication and Informatics)
Aim: Older patients with chronic hepatitis C infection starting direct-acting antivirals (DAAs) are frequently prescribed multiple medications that may be categorized as inappropriate. Anticholinergic burden has been shown to be a predictor of adverse health and functional outcomes. Different scales are available to calculate anticholinergic burden. The aim of this study was to determine the prevalence of anticholinergic medication among older patients treated with DAAs and the risk factors associated using the Anticholinergic Cognitive Burden (ACB) scale, the Anticholinergic Risk Scale (ARS) and the Anticholinergic Drug Scale (ADS) and analyze the resulting safety consequences. Methods: Observational, retrospective cohort study of consecutive patients ≥65 years old receiving DAAs and taking concomitant medication. This study was conducted in accordance with the Strengthening the Reporting of observational studies in Epidemiology Statement. Results: 236 patients were included. The average age was 71.7 years, 73.3% cirrhotic, and 47% patients took ≥5 medicines. According to the ACB, ARS and ADS scales, 35.2% (n = 83), 10.6% (n = 25) and 34.3% (n = 81) of the patients were treated with anticholinergic medication. Two hundred-and-six (86%) patients presented any adverse events (AEs) during therapy. ARS scale showed a significant relationship between presence of anticholinergic medication and AEs. A large number of patients suffered anticholinergic events, with more events per patient in patients taking anticholinergic drugs. Conclusions: Older hepatitis C chronic patients are exposed to potentially inappropriate polypharmacy and anticholinergic risk, according to the ACB, ARS and ADS scales. The three scales showed different results. Only the ARS scale was associated with AEs, but the rate of anticholinergic effects per patient was significantly higher in patients with anticholinergic drugs, regardless of the scale used. Consider quality of pharmacotherapy when starting DAA with a multidisciplinary approach could improve health outcomes. View Full-Text
Keywords: ageing; patient safety; drug use; adverse events; polypharmacy ageing; patient safety; drug use; adverse events; polypharmacy
Show Figures

Figure 1

MDPI and ACS Style

Amoros-Reboredo, P.; Soy, D.; Hernandez-Hernandez, M.; Lens, S.; Mestres, C. Anticholinergic Burden and Safety Outcomes in Older Patients with Chronic Hepatitis C: A Retrospective Cohort Study. Int. J. Environ. Res. Public Health 2020, 17, 3776. https://doi.org/10.3390/ijerph17113776

AMA Style

Amoros-Reboredo P, Soy D, Hernandez-Hernandez M, Lens S, Mestres C. Anticholinergic Burden and Safety Outcomes in Older Patients with Chronic Hepatitis C: A Retrospective Cohort Study. International Journal of Environmental Research and Public Health. 2020; 17(11):3776. https://doi.org/10.3390/ijerph17113776

Chicago/Turabian Style

Amoros-Reboredo, Patricia, Dolors Soy, Marta Hernandez-Hernandez, Sabela Lens, and Conxita Mestres. 2020. "Anticholinergic Burden and Safety Outcomes in Older Patients with Chronic Hepatitis C: A Retrospective Cohort Study" International Journal of Environmental Research and Public Health 17, no. 11: 3776. https://doi.org/10.3390/ijerph17113776

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop