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Marine Drugs
Volume 5
Issue 2
10.3390/md502023
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Article

Large-Scale Biotechnological Production of the Antileukemic Marine Natural Product Sorbicillactone A

by
Gerhard Bringmann
1,*,
Tobias A. M. Gulder
1,
Gerhard Lang
1,
Stefanie Schmitt
1,
Rüdiger Stöhr
2,
Jutta Wiese
2,
Kerstin Nagel
2 and
Johannes F. Imhoff
2,*
1
Institut für Organische Chemie, Universität Würzburg, Am Hubland, D-97074 Würzburg, Germany
2
Marine Mikrobiologie, Leibniz-Institut für Meereswissenschaften, IFM-GEOMAR, Düsternbrooker Weg 20, D-24105 Kiel, Germany
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2007, 5(2), 23-30; https://doi.org/10.3390/md502023
Submission received: 29 May 2007 / Accepted: 29 June 2007 / Published: 25 June 2007
(This article belongs to the Special Issue Marine Natural Products as Anti-Cancer Agents)
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Abstract

In the search for novel bioactive compounds from sponge-derived microorganisms, we have recently identified two structurally and biosynthetically unprecedented fungal metabolites, the novel-type alkaloids sorbicillactone A and sorbicillactone B. Sorbicillactone A is active against leukemia cells without showing notable cytotoxicity. Therefore, we have developed an efficient process for its biotechnological production and isolation on a large scale supplying sufficient material for the ongoing preclinical investigations and structure-activity relationship (SAR) studies.
Keywords: sorbicillactone A; anti-leukemic activity; large-scale production; BIOTECmarin. sorbicillactone A; anti-leukemic activity; large-scale production; BIOTECmarin.

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MDPI and ACS Style

Bringmann, G.; Gulder, T.A.M.; Lang, G.; Schmitt, S.; Stöhr, R.; Wiese, J.; Nagel, K.; Imhoff, J.F. Large-Scale Biotechnological Production of the Antileukemic Marine Natural Product Sorbicillactone A. Mar. Drugs 2007, 5, 23-30. https://doi.org/10.3390/md502023

AMA Style

Bringmann G, Gulder TAM, Lang G, Schmitt S, Stöhr R, Wiese J, Nagel K, Imhoff JF. Large-Scale Biotechnological Production of the Antileukemic Marine Natural Product Sorbicillactone A. Marine Drugs. 2007; 5(2):23-30. https://doi.org/10.3390/md502023

Chicago/Turabian Style

Bringmann, Gerhard, Tobias A. M. Gulder, Gerhard Lang, Stefanie Schmitt, Rüdiger Stöhr, Jutta Wiese, Kerstin Nagel, and Johannes F. Imhoff. 2007. "Large-Scale Biotechnological Production of the Antileukemic Marine Natural Product Sorbicillactone A" Marine Drugs 5, no. 2: 23-30. https://doi.org/10.3390/md502023

APA Style

Bringmann, G., Gulder, T. A. M., Lang, G., Schmitt, S., Stöhr, R., Wiese, J., Nagel, K., & Imhoff, J. F. (2007). Large-Scale Biotechnological Production of the Antileukemic Marine Natural Product Sorbicillactone A. Marine Drugs, 5(2), 23-30. https://doi.org/10.3390/md502023

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