Mansouramycins E–G, Cytotoxic Isoquinolinequinones from Marine Streptomycetes

Shaaban, Mohamed; Shaaban, Khaled A.; Kelter, Gerhard; Fiebig, Heinz Herbert; Laatsch, Hartmut

doi:10.3390/md19120715

Open AccessArticle

Mansouramycins E–G, Cytotoxic Isoquinolinequinones from Marine Streptomycetes

by

Mohamed Shaaban

^1,2,†,

Khaled A. Shaaban

^1,†,‡

,

Gerhard Kelter

³,

Heinz Herbert Fiebig

⁴ and

Hartmut Laatsch

^1,*

¹

Institute of Organic and Biomolecular Chemistry, University of Göttingen, Tammannstrasse 2, D-37077 Göttingen, Germany

²

National Research Centre, Chemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Institute, El-Behoos St. 33, Giza 12622, Egypt

³

Oncotest GmbH, Charles River Discovery Germany, Am Flughafen 14, D-79108 Freiburg, Germany

⁴

Oncotest GmbH, Biotec GmbH, Am Flughafen 14, D-79108 Freiburg, Germany

^*

Author to whom correspondence should be addressed.

^†

Authors contributed equally to this work.

^‡

Current address: Center for Pharmaceutical Research and Innovation, Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA.

Mar. Drugs 2021, 19(12), 715; https://doi.org/10.3390/md19120715

Submission received: 11 November 2021 / Revised: 2 December 2021 / Accepted: 8 December 2021 / Published: 20 December 2021

(This article belongs to the Special Issue Marine Microbial Diversity as Source of Bioactive Compounds)

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Abstract

Chemical investigation of the ethyl acetate extract from the marine-derived Streptomyces sp. isolate B1848 resulted in three new isoquinolinequinone derivatives, the mansouramycins E–G (1a–3a), in addition to the previously reported mansouramycins A (5) and D (6). Their structures were elucidated by computer-assisted interpretation of 1D and 2D NMR spectra, high-resolution mass spectrometry, and by comparison with related compounds. Cytotoxicity profiling of the mansouramycins in a panel of up to 36 tumor cell lines indicated a significant cytotoxicity and good tumor selectivity for mansouramycin F (2a), while the activity profile of E (1a) was less attractive.

Keywords: mansouramycins; isoquinolinequinones; marine-derived Streptomyces sp.; cytotoxicity

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MDPI and ACS Style

Shaaban, M.; Shaaban, K.A.; Kelter, G.; Fiebig, H.H.; Laatsch, H. Mansouramycins E–G, Cytotoxic Isoquinolinequinones from Marine Streptomycetes. Mar. Drugs 2021, 19, 715. https://doi.org/10.3390/md19120715

AMA Style

Shaaban M, Shaaban KA, Kelter G, Fiebig HH, Laatsch H. Mansouramycins E–G, Cytotoxic Isoquinolinequinones from Marine Streptomycetes. Marine Drugs. 2021; 19(12):715. https://doi.org/10.3390/md19120715

Chicago/Turabian Style

Shaaban, Mohamed, Khaled A. Shaaban, Gerhard Kelter, Heinz Herbert Fiebig, and Hartmut Laatsch. 2021. "Mansouramycins E–G, Cytotoxic Isoquinolinequinones from Marine Streptomycetes" Marine Drugs 19, no. 12: 715. https://doi.org/10.3390/md19120715

APA Style

Shaaban, M., Shaaban, K. A., Kelter, G., Fiebig, H. H., & Laatsch, H. (2021). Mansouramycins E–G, Cytotoxic Isoquinolinequinones from Marine Streptomycetes. Marine Drugs, 19(12), 715. https://doi.org/10.3390/md19120715

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Mansouramycins E–G, Cytotoxic Isoquinolinequinones from Marine Streptomycetes

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