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Keywords = mansouramycins

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Article
Mansouramycins E–G, Cytotoxic Isoquinolinequinones from Marine Streptomycetes
by Mohamed Shaaban, Khaled A. Shaaban, Gerhard Kelter, Heinz Herbert Fiebig and Hartmut Laatsch
Mar. Drugs 2021, 19(12), 715; https://doi.org/10.3390/md19120715 - 20 Dec 2021
Cited by 12 | Viewed by 3325
Abstract
Chemical investigation of the ethyl acetate extract from the marine-derived Streptomyces sp. isolate B1848 resulted in three new isoquinolinequinone derivatives, the mansouramycins E–G (1a3a), in addition to the previously reported mansouramycins A (5) and D (6 [...] Read more.
Chemical investigation of the ethyl acetate extract from the marine-derived Streptomyces sp. isolate B1848 resulted in three new isoquinolinequinone derivatives, the mansouramycins E–G (1a3a), in addition to the previously reported mansouramycins A (5) and D (6). Their structures were elucidated by computer-assisted interpretation of 1D and 2D NMR spectra, high-resolution mass spectrometry, and by comparison with related compounds. Cytotoxicity profiling of the mansouramycins in a panel of up to 36 tumor cell lines indicated a significant cytotoxicity and good tumor selectivity for mansouramycin F (2a), while the activity profile of E (1a) was less attractive. Full article
(This article belongs to the Special Issue Marine Microbial Diversity as Source of Bioactive Compounds)
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