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Article

Anti-Inflammatory Activity of Fucoidan Extracts In Vitro

1
School of Health Sciences, University of Tasmania, Launceston, TAS 7248, Australia
2
Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, TAS 7248, Australia
3
School of Pharmacy and Pharmacology, University of Tasmania, Hobart, TAS 7005, Australia
4
Marinova Pty Ltd., Cambridge, TAS 7170, Australia
5
RDadvisor, Hobart, TAS 7006, Australia
6
ISAL Foundation, Research on Pain, Torre Pedrera, 204-47922 Rimini, Italy
*
Authors to whom correspondence should be addressed.
Academic Editor: You-Jin Jeon
Mar. Drugs 2021, 19(12), 702; https://doi.org/10.3390/md19120702
Received: 14 October 2021 / Revised: 25 November 2021 / Accepted: 1 December 2021 / Published: 11 December 2021
(This article belongs to the Special Issue Fucoidans Ⅱ: Immunomodulating Activity of Fucoidans)
Fucoidans are sulfated, complex, fucose-rich polymers found in brown seaweeds. Fucoidans have been shown to have multiple bioactivities, including anti-inflammatory effects, and are known to inhibit inflammatory processes via a number of pathways such as selectin blockade and enzyme inhibition, and have demonstrated inhibition of inflammatory pathologies in vivo. In this current investigation, fucoidan extracts from Undaria pinnatifida, Fucus vesiculosus, Macrocystis pyrifera, Ascophyllum nodosum, and Laminaria japonica were assessed for modulation of pro-inflammatory cytokine production (TNF-α, IL-1β, and IL-6) by human peripheral blood mononuclear cells (PBMCs) and in a human macrophage line (THP-1). Fucoidan extracts exhibited no signs of cytotoxicity in THP-1 cells after incubation of 48 h. Additionally, all fucoidan extracts reduced cytokine production in LPS stimulated PBMCs and human THP-1 cells in a dose-dependent fashion. Notably, the 5–30 kDa subfraction from Macrocystis pyrifera was a highly effective inhibitor at lower concentrations. Fucoidan extracts from all species had significant anti-inflammatory effects, but the lowest molecular weight subfractions had maximal effects at low concentrations. These observations on various fucoidan extracts offer insight into strategies that improve their efficacy against inflammation-related pathology. Further studies should be conducted to elucidate the mechanism of action of these extracts. View Full-Text
Keywords: fucoidan; PBMCs; THP-1; TNF-α, IL-1β, and IL-6; Undaria pinnatifida; Fucus vesiculosus; Macrocystis pyrifera; Ascophyllum nodosum; Laminaria japonica fucoidan; PBMCs; THP-1; TNF-α, IL-1β, and IL-6; Undaria pinnatifida; Fucus vesiculosus; Macrocystis pyrifera; Ascophyllum nodosum; Laminaria japonica
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MDPI and ACS Style

Ahmad, T.; Eapen, M.S.; Ishaq, M.; Park, A.Y.; Karpiniec, S.S.; Stringer, D.N.; Sohal, S.S.; Fitton, J.H.; Guven, N.; Caruso, V.; Eri, R. Anti-Inflammatory Activity of Fucoidan Extracts In Vitro. Mar. Drugs 2021, 19, 702. https://doi.org/10.3390/md19120702

AMA Style

Ahmad T, Eapen MS, Ishaq M, Park AY, Karpiniec SS, Stringer DN, Sohal SS, Fitton JH, Guven N, Caruso V, Eri R. Anti-Inflammatory Activity of Fucoidan Extracts In Vitro. Marine Drugs. 2021; 19(12):702. https://doi.org/10.3390/md19120702

Chicago/Turabian Style

Ahmad, Tauseef, Mathew S. Eapen, Muhammad Ishaq, Ah Y. Park, Samuel S. Karpiniec, Damien N. Stringer, Sukhwinder S. Sohal, J. H. Fitton, Nuri Guven, Vanni Caruso, and Rajaraman Eri. 2021. "Anti-Inflammatory Activity of Fucoidan Extracts In Vitro" Marine Drugs 19, no. 12: 702. https://doi.org/10.3390/md19120702

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