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Open AccessArticle

Targeted Isolation of Rubrolides from the New Zealand Marine Tunicate Synoicum kuranui

1
School of Chemical and Physical Sciences, Victoria University of Wellington, Wellington 6012, New Zealand
2
Centre for Biodiscovery, Victoria University of Wellington, Wellington 6012, New Zealand
3
Maurice Wilkins Centre for Molecular Biodiscovery, Auckland 1142, New Zealand
4
School of Biological Sciences, Victoria University of Wellington, Wellington 6012, New Zealand
5
National Institute of Water & Atmospheric Research (NIWA), P.O. Box 893, Nelson 7010, New Zealand
*
Author to whom correspondence should be addressed.
Mar. Drugs 2020, 18(7), 337; https://doi.org/10.3390/md18070337
Received: 3 June 2020 / Revised: 22 June 2020 / Accepted: 23 June 2020 / Published: 27 June 2020
(This article belongs to the Special Issue Marine Natural Product of the South Pacific Area)
Global natural products social (GNPS) molecular networking is a useful tool to categorize chemical space within samples and streamline the discovery of new natural products. Here, we demonstrate its use in chemically profiling the extract of the marine tunicate Synoicum kuranui, comprised of many previously reported rubrolides, for new chemical entities. Within the rubrolide cluster, two masses that did not correspond to previously reported congeners were detected, and, following MS-guided fractionation, led to the isolation of new methylated rubrolides T (3) and (Z/E)–U (4). Both compounds showed strong growth inhibitory activity against the Gram-positive bacteria Bacillus subtilis, with minimum inhibitory concentration (MIC) values of 0.41 and 0.91 μM, respectively. View Full-Text
Keywords: rubrolide; GNPS; Synoicum kuranui; antibacterial rubrolide; GNPS; Synoicum kuranui; antibacterial
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MDPI and ACS Style

Bracegirdle, J.; Stevenson, L.J.; Page, M.J.; Owen, J.G.; Keyzers, R.A. Targeted Isolation of Rubrolides from the New Zealand Marine Tunicate Synoicum kuranui. Mar. Drugs 2020, 18, 337.

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