Sign in to use this feature.

Years

Between: -

Subjects

remove_circle_outline
remove_circle_outline
remove_circle_outline

Journals

Article Types

Countries / Regions

Search Results (1)

Search Parameters:
Keywords = Synoicum kuranui

Order results
Result details
Results per page
Select all
Export citation of selected articles as:
12 pages, 1979 KiB  
Article
Targeted Isolation of Rubrolides from the New Zealand Marine Tunicate Synoicum kuranui
by Joe Bracegirdle, Luke J. Stevenson, Michael J. Page, Jeremy G. Owen and Robert A. Keyzers
Mar. Drugs 2020, 18(7), 337; https://doi.org/10.3390/md18070337 - 27 Jun 2020
Cited by 9 | Viewed by 4035
Abstract
Global natural products social (GNPS) molecular networking is a useful tool to categorize chemical space within samples and streamline the discovery of new natural products. Here, we demonstrate its use in chemically profiling the extract of the marine tunicate Synoicum kuranui, comprised of [...] Read more.
Global natural products social (GNPS) molecular networking is a useful tool to categorize chemical space within samples and streamline the discovery of new natural products. Here, we demonstrate its use in chemically profiling the extract of the marine tunicate Synoicum kuranui, comprised of many previously reported rubrolides, for new chemical entities. Within the rubrolide cluster, two masses that did not correspond to previously reported congeners were detected, and, following MS-guided fractionation, led to the isolation of new methylated rubrolides T (3) and (Z/E)–U (4). Both compounds showed strong growth inhibitory activity against the Gram-positive bacteria Bacillus subtilis, with minimum inhibitory concentration (MIC) values of 0.41 and 0.91 μM, respectively. Full article
(This article belongs to the Special Issue Marine Natural Product of the South Pacific Area)
Show Figures

Graphical abstract

Back to TopTop