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Open AccessFeature PaperArticle

Hydrothermal Processing of Laminaria ochroleuca for the Production of Crude Extracts Used to Formulate Polymeric Nanoparticles

1
Department of Chemical Engineering, University of Vigo, Campus Ourense, As Lagoas, 32004 Ourense, Spain
2
Centre for Marine Sciences, Universidade do Algarve, Gambelas Campus, 8005-139 Faro, Portugal
3
Drug Delivery Laboratory, Faculty of Sciences and Technology, Universidade do Algarve, Gambelas Campus, 8005-139 Faro, Portugal
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2020, 18(7), 336; https://doi.org/10.3390/md18070336
Received: 15 May 2020 / Revised: 22 June 2020 / Accepted: 24 June 2020 / Published: 27 June 2020
A green extraction process using only water was proposed for the simultaneous extraction of alginate and bioactive compounds from Laminaria ochroleuca. Operation was carried out during non-isothermal heating up to maximal temperatures over the range of 70 °C to 100 °C. Once separated, the alginate and the crude extract were characterised and the biological activities and cytotoxicity of the extracts was studied, the latter in intestinal epithelial cells. Those alginates obtained at 90 °C exhibited the highest extraction yields and viscoelastic features of the corresponding hydrogels. The obtained results show that the extracts obtained by non-isothermal extraction were suitable to formulate nanoparticles, which showed the smallest size (≈250–350 nm) when the higher content of fucoidan extract was present. Given the evidenced properties, the extracts may find an application in the formulation of nanoparticulate carriers for drug delivery. View Full-Text
Keywords: environmentally friendly extraction technologies; bioactive compounds; polymeric nanoparticles; cytotoxicity environmentally friendly extraction technologies; bioactive compounds; polymeric nanoparticles; cytotoxicity
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MDPI and ACS Style

Flórez-Fernández, N.; Álvarez-Viñas, M.; Guerreiro, F.; Torres, M.D.; Grenha, A.; Domínguez, H. Hydrothermal Processing of Laminaria ochroleuca for the Production of Crude Extracts Used to Formulate Polymeric Nanoparticles. Mar. Drugs 2020, 18, 336.

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