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Quorum Sensing Inhibitory and Antifouling Activities of New Bromotyrosine Metabolites from the Polynesian Sponge Pseudoceratina n. sp.

1
IRD, Université de la Polynésie française, Ifremer, ILM, EIO, Papeete F-98713, French Polynesia
2
Université Paris-Saclay, CNRS, Institut de Chimie des Substances Naturelles, 91190 Gif-sur-Yvette, France
3
IRD, Univ Brest, CNRS, Ifremer, LEMAR, F-29280 Plouzane, France
4
Ifremer, IRD, ILM, Université de la Polynésie française, EIO, Taravao F-98719, French Polynesia
5
Queensland Museum, PO Box 3300, South Brisbane BC, Queensland 4101, Australia
*
Author to whom correspondence should be addressed.
Mar. Drugs 2020, 18(5), 272; https://doi.org/10.3390/md18050272
Received: 3 April 2020 / Revised: 15 May 2020 / Accepted: 19 May 2020 / Published: 21 May 2020
(This article belongs to the Special Issue Marine Natural Product of the South Pacific Area)
Four new brominated tyrosine metabolites, aplyzanzines C–F (14), were isolated from the French Polynesian sponge Pseudoceratina n. sp., along with the two known 2-aminoimidazolic derivatives, purealidin A (5) and 6, previously isolated, respectively, from the sponges Psammaplysilla purpurea and Verongula sp. Their structures were assigned based on the interpretation of their NMR and HRMS data. The compounds exhibited quorum sensing inhibition (QSi) and antifouling activities against several strains of bacteria and microalgae. To our knowledge, the QSi activity of this type of bromotyrosine metabolite is described here for the first time. View Full-Text
Keywords: sponge; Pseudoceratina; quorum sensing inhibitory activity; antifouling; Verongiida; bromotyrosine sponge; Pseudoceratina; quorum sensing inhibitory activity; antifouling; Verongiida; bromotyrosine
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MDPI and ACS Style

Tintillier, F.; Moriou, C.; Petek, S.; Fauchon, M.; Hellio, C.; Saulnier, D.; Ekins, M.; Hooper, J.N.A.; Al-Mourabit, A.; Debitus, C. Quorum Sensing Inhibitory and Antifouling Activities of New Bromotyrosine Metabolites from the Polynesian Sponge Pseudoceratina n. sp.. Mar. Drugs 2020, 18, 272.

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