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Open AccessArticle

Absorption and Tissue Distribution of Siphonaxanthin from Green Algae

Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University, Kyoto 6068502, Japan
Department of Rehabilitation, Shijonawate Gakuen University, Osaka 5740011, Japan
Author to whom correspondence should be addressed.
Mar. Drugs 2020, 18(6), 291;
Received: 10 April 2020 / Revised: 21 May 2020 / Accepted: 24 May 2020 / Published: 1 June 2020
(This article belongs to the Collection Marine Carotenoids)
Siphonaxanthin has been known to possess inhibitory effects against obesity, inflammation, and angiogenesis. However, little information on its in vivo bioavailability and biotransformation is available. To assess the bioavailability and metabolism of siphonaxanthin, its absorption and accumulation were evaluated using intestinal Caco-2 cells and Institute of Cancer Research (ICR) mice. Siphonaxanthin was absorbed and exhibited non-uniform accumulation and distribution patterns in tissues of ICR mice. Notably, in addition to siphonaxanthin, three main compounds were detected following dietary administration of siphonaxanthin. Because the compounds showed changes on mass spectra compared with that of siphonaxanthin, they were presumed to be metabolites of siphonaxanthin in ICR mice. Siphonaxanthin mainly accumulated in stomach and small intestine, while putative metabolites of siphonaxanthin mainly accumulated in liver and adipose tissues. Furthermore, siphonaxanthin and its putative metabolites selectively accumulated in white adipose tissue (WAT), especially mesenteric WAT. These results provide useful evidence regarding the in vivo bioactivity of siphonaxanthin. In particular, the results regarding the specific accumulation of siphonaxanthin and its metabolites in WAT have important implications for understanding their anti-obesity effects and regulatory roles in lipid metabolism. View Full-Text
Keywords: siphonaxanthin; dehydro-metabolite; white adipose tissue; metabolic pathway in vivo siphonaxanthin; dehydro-metabolite; white adipose tissue; metabolic pathway in vivo
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Li, Z.; Zheng, J.; Luo, X.; Manabe, Y.; Hirata, T.; Sugawara, T. Absorption and Tissue Distribution of Siphonaxanthin from Green Algae. Mar. Drugs 2020, 18, 291.

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