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The Biological and Chemical Diversity of Tetramic Acid Compounds from Marine-Derived Microorganisms

by Minghua Jiang 1,2,†, Senhua Chen 1,2,3,*,†, Jing Li 1,2,3 and Lan Liu 1,2,3,*
1
School of Marine Sciences, Sun Yat-sen University, Guangzhou 510006, China
2
South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center, Guangzhou 510006, China
3
Southern Laboratory of Ocean Science and Engineering (Guangdong, Zhuhai), Zhuhai 519000, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Mar. Drugs 2020, 18(2), 114; https://doi.org/10.3390/md18020114
Received: 25 January 2020 / Revised: 12 February 2020 / Accepted: 14 February 2020 / Published: 15 February 2020
Tetramic acid (pyrrolidine-2,4-dione) compounds, isolated from a variety of marine and terrestrial organisms, have attracted considerable attention for their diverse, challenging structural complexity and promising bioactivities. In the past decade, marine-derived microorganisms have become great repositories of novel tetramic acids. Here, we discuss the biological activities of 277 tetramic acids of eight classifications (simple 3-acyl tetramic acids, 3-oligoenoyltetramic acids, 3-decalinoyltetramic acid, 3-spirotetramic acids, macrocyclic tetramic acids, N-acylated tetramic acids, α-cyclopiazonic acid-type tetramic acids, and other tetramic acids) from marine-derived microbes, including fungi, actinobacteria, bacteria, and cyanobacteria, as reported in 195 research studies up to 2019. View Full-Text
Keywords: tetramic acid; bioactivity; marine natural product; marine-derived microorganisms tetramic acid; bioactivity; marine natural product; marine-derived microorganisms
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Jiang, M.; Chen, S.; Li, J.; Liu, L. The Biological and Chemical Diversity of Tetramic Acid Compounds from Marine-Derived Microorganisms. Mar. Drugs 2020, 18, 114.

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