Next Article in Journal
Modulation of the Liver Protein Carbonylome by the Combined Effect of Marine Omega-3 PUFAs and Grape Polyphenols Supplementation in Rats Fed an Obesogenic High Fat and High Sucrose Diet
Next Article in Special Issue
Synthesis of Bioactive Silver Nanoparticles by a Pseudomonas Strain Associated with the Antarctic Psychrophilic Protozoon Euplotes focardii
Previous Article in Journal
Elucidation of a Unique Pattern and the Role of Carbohydrate Binding Module of an Alginate Lyase
Previous Article in Special Issue
Deep-Sea Fungi Could Be the New Arsenal for Bioactive Molecules
Open AccessReview

Halophiles and Their Biomolecules: Recent Advances and Future Applications in Biomedicine

1
Department of Biology, University of Naples Federico II, 80126 Naples, Italy
2
Department of Microbiology and Parasitology, Faculty of Pharmacy, University of Sevilla, 41012 Sevilla, Spain
3
Department of Microbiology, School of Biology, College of Science, University of Tehran, Tehran 14155-6955, Iran
*
Author to whom correspondence should be addressed.
Mar. Drugs 2020, 18(1), 33; https://doi.org/10.3390/md18010033
Received: 30 November 2019 / Revised: 21 December 2019 / Accepted: 28 December 2019 / Published: 30 December 2019
(This article belongs to the Special Issue Bioactive Molecules from Extreme Environments)
The organisms thriving under extreme conditions better than any other organism living on Earth, fascinate by their hostile growing parameters, physiological features, and their production of valuable bioactive metabolites. This is the case of microorganisms (bacteria, archaea, and fungi) that grow optimally at high salinities and are able to produce biomolecules of pharmaceutical interest for therapeutic applications. As along as the microbiota is being approached by massive sequencing, novel insights are revealing the environmental conditions on which the compounds are produced in the microbial community without more stress than sharing the same substratum with their peers, the salt. In this review are reported the molecules described and produced by halophilic microorganisms with a spectrum of action in vitro: antimicrobial and anticancer. The action mechanisms of these molecules, the urgent need to introduce alternative lead compounds and the current aspects on the exploitation and its limitations are discussed. View Full-Text
Keywords: halophilic bacteria; archaea and fungi; biomolecules; biomedicine; antimicrobial compounds; anticancer compounds halophilic bacteria; archaea and fungi; biomolecules; biomedicine; antimicrobial compounds; anticancer compounds
MDPI and ACS Style

Corral, P.; Amoozegar, M.A.; Ventosa, A. Halophiles and Their Biomolecules: Recent Advances and Future Applications in Biomedicine. Mar. Drugs 2020, 18, 33.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop