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Open AccessArticle

Halogenated Diterpenes with In Vitro Antitumor Activity from the Red Alga Sphaerococcus coronopifolius

1
Section of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece
2
Postgraduate Program in Bioactive Natural and Synthetic Products, Health Sciences Center, Federal University of Paraíba, João Pessoa 58051-970, PB, Brazil
3
Fonds National de la Recherche Scientifique, 1050 Bruxelles, Belgium
4
Department of Pharmacotherapy and Pharmaceutics, Université Libre de Bruxelles, Boulevard du Triomphe, 1050 Brussels, Belgium
5
ULB Cancer Research Center, Université Libre de Bruxelles, Boulevard du Triomphe, 1050 Brussels, Belgium
*
Author to whom correspondence should be addressed.
Present address: Hospital Universitário Professor Alberto Antunes, Maceió 57072-900, AL, Brazil.
Present address: Department of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa 58051-900, PB, Brazil.
§
Present address: Department of Pharmacy, Center of Health and Biological Sciences, State University of Paraiba, Campina Grande 58100-000, PB, Brazil.
Retired.
Mar. Drugs 2020, 18(1), 29; https://doi.org/10.3390/md18010029
Received: 24 November 2019 / Revised: 24 December 2019 / Accepted: 25 December 2019 / Published: 29 December 2019
(This article belongs to the Special Issue Terpenoids from Marine Organisms II)
Eight new (18) structurally diverse diterpenes featuring five different carbocycles were isolated from the organic extracts of the red alga Sphaerococcus coronopifolius collected from the coastline of the Ionian Sea in Greece. The structures of the new natural products, seven of which were halogenated, and the relative configuration of their stereocenters were determined on the basis of comprehensive spectroscopic analyses, including NMR and HRMS data. Compounds 5 and 8 were found to possess in vitro antitumor activity against one murine and five human cancer cell lines with mean IC50 values 15 and 16 μM, respectively. View Full-Text
Keywords: Sphaerococcus coronopifolius; red algae; halogenated diterpenes; structure elucidation; antitumor activity Sphaerococcus coronopifolius; red algae; halogenated diterpenes; structure elucidation; antitumor activity
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Smyrniotopoulos, V.; de Andrade Tomaz, A.C.; Vanderlei de Souza, M.F.; Leitão da Cunha, E.V.; Kiss, R.; Mathieu, V.; Ioannou, E.; Roussis, V. Halogenated Diterpenes with In Vitro Antitumor Activity from the Red Alga Sphaerococcus coronopifolius. Mar. Drugs 2020, 18, 29.

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